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Archives of Dermatological Research
Published in: Archives of Dermatological Research 1/2013

01-01-2013 | Original Paper

Association between TERT-CLPTM1L rs401681[C] allele and NMSC cancer risk: a meta-analysis including 45,184 subjects

Authors: Xueling Yang, Baohong Yang, Bo Li, Ya Liu

Published in: Archives of Dermatological Research | Issue 1/2013

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Abstract

Single-nucleotide polymorphism of CLPTM1L-rs401681(C > T) at the 5p15.33 locus is significantly associated with cancer risk as reported in genome-wide association studies, but the reported studies for non-melanoma skin cancer (NMSC) are inconclusive. To assess the association between rs401681[C] allele and NMSC risk, we performed this meta-analysis with four case–control studies involving 5,469 cases and 39,715 controls. Our meta-analysis showed that rs401681[C] allele was associated with NMSC susceptibility in the overall subjects (C vs. T, OR 1.13, 95 % CI 1.07–1.20). In the stratified analysis, the rs401681[C] allele confers susceptibility in Icelanders (C vs. T, OR 1.15, 95 % CI 1.06–1.26) and non-Icelanders (C vs. T, OR 1.13, 95 % CI 1.03–1.24). In the subtype analysis, we found that rs401681[C] allele was a risk factor for BCC, but not SCC in the overall subjects.
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Metadata
Title
Association between TERT-CLPTM1L rs401681[C] allele and NMSC cancer risk: a meta-analysis including 45,184 subjects
Authors
Xueling Yang
Baohong Yang
Bo Li
Ya Liu
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
Archives of Dermatological Research / Issue 1/2013
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-012-1275-8

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