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Osteoporosis International

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01-10-2011 | Original Article

Effects of calcium-fortified ice cream on markers of bone health

Authors: L. Ferrar, R. M. van der Hee, M. Berry, C. Watson, S. Miret, J. Wilkinson, M. Bradburn, R. Eastell

Published in: Osteoporosis International | Issue 10/2011

Abstract

Summary

Premenopausal women with low calcium intakes consumed calcium-fortified ice cream daily for 28 days. Bone markers, NTX, CTX and PTH decreased significantly by 7 days, with some evidence of a calcium dose-dependent effect. Bone marker responses were observed within 1 h of consuming ice cream. Body weight remained constant over 28 days.

Introduction

Dietary calcium is important for lifelong bone health. Milk is a good source of bioavailable calcium, but consumption has declined among young adults. The aims were to determine whether calcium-fortified ice cream, a palatable source of calcium, produces significant, sustainable changes in bone turnover markers and parathyroid hormone (PTH) in premenopausal women with calcium intake below recommended UK levels.

Methods

Eighty women, ages 20–39 years (calcium intake <750 mg/day) were randomised to consume lower saturated fat/sugar ice cream containing 96, 244, 459 or 676 mg calcium daily for 28 days. Urinary NTX/Cr, serum CTX, PINP, 1,25D and PTH were measured (baseline, days 1, 7 and 28). Acute changes in CTX and PTH were measured over 5 h (n = 29 women).

Results

There were significant mean decreases by 7 days in NTX/Cr, CTX, PTH and 1,25D and increases in PINP (one sample t tests), with a significant dose-dependent effect on CTX analysis of covariance. Only CTX remained suppressed at 28 days. Serum CTX and PTH decreased within 1 h. Body weight did not change significantly between baseline and 28 days.

Conclusions

Daily consumption of calcium-fortified ice cream by premenopausal women may significantly reduce levels of the bone resorption marker serum CTX, without stimulating weight gain. The ice cream could be incorporated into the diet to replace low-calcium snacks and thus help individuals with habitually low calcium intakes to meet recommended intakes. The 244 mg calcium preparation would provide more than a quarter of the UK daily recommended nutrient intake for premenopausal women.

The term “ice cream” is used in a generic sense: the study product was formulated to be suitable for daily consumption (lower saturated fat/sugar).

Heaney RP (2007) Bone health. Am J Clin Nutr 85(1):300S–303SPubMed

Flynn A, Cashman KD (1999) Calcium. In: Hurrell R (ed) The mineral fortification of foods. Leatherhead Food Research Association, Leatherhead, Surrey, pp 18–53

Matkovic V (1996) Nutrition, genetics and skeletal development. J Am Coll Nutr 15(6):556–569PubMed

Dawson-Hughes B (1996) Calcium insufficiency and fracture risk. Osteoporos Int Suppl 3:37–41CrossRef

Newmark HL, Heaney RP, Lachance PA (2004) Should calcium and vitamin D be added to the current enrichment program for cereal-grain products? Am J Clin Nutr 80:264–270PubMed

Flynn A (2003) The role of dietary calcium in bone health. Proc Nutr Soc 62:851–858PubMedCrossRef

U.S. Department of Agriculture. Results from the United States Department of Agriculture’s 1994 –96 Continuing Survey of Food Intakes by Individuals/Diet and Health Knowledge Survey, 1994 –96

Guenther PM (1986) Beverages in the diets of American teenagers. J Am Diet Assoc 86(4):493–499PubMed

Hamrack L, Stang J, Story M (1999) Soft drink consumption among US children and adolescents: nutritional consequences. J Am Diet Assoc 99:436–441CrossRef

10.

Bowman SA (2002) Beverage choices of young females: changes and impact on nutrient intakes. J Am Diet Assoc 102(9):1234–1239PubMedCrossRef

11.

Ballew C, Ballew C, Kuester S et al (2000) Beverage choices affect adequacy of children’s nutrient intakes. Arch Pediatr Adolesc Med 154(11):1148–1152PubMed

12.

Cashman KD (2002) Calcium intake, calcium bioavailability and bone health. Br J Nutr 87(Suppl 2):S169–S177PubMedCrossRef

13.

Heaney RP (2000) Calcium, dairy products and osteoporosis. J Am Coll Nutr 19(2):83S–99SPubMed

14.

Prentice A (2004) Diet, nutrition and the prevention of osteoporosis. Pub Health Nutr 71(1A):22–43

15.

Fardellone P, Brazier M, Kamel S et al (1998) Biochemical effects of calcium supplementation in postmenopausal women: influence of dietary calcium intake. Am J Clin Nutr 67(6):1273–1278PubMed

16.

Allen L, de Benoist B, Dary O et al (2006) Guidelines on food fortification with micronutrients. World Health Organization and Food and Agriculture Organization of the United Nations, Geneva

17.

Van der Hee RM, Miret S, Slettenaar M et al (2009) Calcium absorption from fortified ice cream formulations compared with calcium absorption from milk. J Am Diet Assoc 109:830–835PubMedCrossRef

18.

Kruger MC, Booth CL, Coad J et al (2006) Effect of calcium fortified milk supplementation with or without vitamin K on biochemical markers of bone turnover in premenopausal women. Nutr 22(11–12):1120–1128CrossRef

19.

Kruger MC, Schollum LM, Kuhn-Sherlock B et al (2010) The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia. Bone 46(3):759–767PubMedCrossRef

20.

Bonjour JP, Brandolini-Bunlon M, Boirie Y et al (2008) Inhibition of bone turnover by milk intake in postmenopausal women. Br J Nutr 100:866–874PubMedCrossRef

21.

Zikan V, Haas T, Stepan JJ (2001) Acute effects in healthy women of oral calcium on the calcium parathyroid axis and bone resorption as assessed by serum beta-CrossLaps. Calcif Tiss Int 68:352–357CrossRef

22.

Green JH, Booth C, Bunning R (2003) Acute effect of high-calcium mild with or without additional magnesium, or calcium phosphate on parathyroid hormone and biochemical markers of bone resorption. Eur J Clin Nutr 57(1):61–68PubMedCrossRef

23.

Kenny AM, Prestwood KM, Biskup B et al (2004) Comparison of the effects of calcium loading with calcium citrate or calcium carbonate on bone turnover in postmenopausal women. Osteoporos Int 15:290–294PubMedCrossRef

24.

Adolphi B, Scholz-Ahrens KE, de Vrese M et al (2009) Short-term effect of bedtime consumption of fermented milk supplemented with calcium, inulin-type fructans and caseinphosphopeptides on bone metabolism in healthy, postmenopausal women. Eur J Nutr 48:45–53PubMedCrossRef

25.

Martini L, Wood RJ (2002) Relative bioavailability of calcium-rich dietary sources in the elderly. Am J Clin Nutr 76(6):1345–1350PubMed

26.

Zou Z-Y, Lin Z-M, Xu X-R et al (2009) Evaluation of milk basic protein supplementation on bone density and bone metabolism in Chinese young women. Eur J Nutr 48:301–306PubMedCrossRef

27.

Manios Y, Moschonis G, Panagiotakos DB et al (2009) Changes in biochemical indices of bone metabolism in post-menopausal women following a dietary intervention with fortified dairy products. J Hum Nutr Diet 22:156–165PubMedCrossRef

Title: Effects of calcium-fortified ice cream on markers of bone health
Authors: L. Ferrar
R. M. van der Hee
M. Berry
C. Watson
S. Miret
J. Wilkinson
M. Bradburn
R. Eastell
Publication date: 01-10-2011
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 10/2011
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-010-1513-x

At a glance: The STEP trials

Springer Medicine

Effects of calcium-fortified ice cream on markers of bone health

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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