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Hernia
Published in: Hernia 1/2008

01-02-2008 | Original Article

Effect of suture material on tensile strength and complication rate in abdominal fascial defects repaired with acellular dermal matrix

Authors: A. A. Winkler, M. L. Milburn, L. T. Holton III, N. H. Goldberg, R. P. Silverman

Published in: Hernia | Issue 1/2008

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Abstract

Background

Repair of ventral hernias represents a challenging problem for surgeons. AlloDerm® (LifeCell, Branchburg, NJ, USA), an acellular dermal matrix (ADM) product derived from cadaveric human skin, has gained in popularity in the management of abdominal hernias because of its ability to support neovascularization and therefore resist infection. Surgeons have traditionally used nonabsorbable suture when using ADM in this setting, perhaps because of concerns regarding wound strength. This study was undertaken to examine the influence of suture material on wound breaking strength and complication rates in abdominal wall defects closed with ADM.

Methods

Full-thickness abdominal defects were created in athymic rats and immediately repaired with an ADM interposition graft using either interrupted Prolene® or Maxon® suture. Complications were recorded over time and the animals were sacrificed at 1 month intervals. The abdominal repair complex was harvested and wound strength was measured using a tensiometer.

Results

There were no hernias in any of the groups. There were also no cases of major adhesions to the AlloDerm®. Two rats in the Prolene® group developed a stitch extrusion through the ventral skin. Wound breaking strength increased significantly from the second to third month after surgery in both suture groups (p = 0.0000, LSD test). The breaking strength of the abdominal fascia-ADM complex increased over the course of the experiment in both test groups, but no significant difference was found between the groups at any time point (p = 0.3157). At 3 months, the breaking strength of the Prolene® group and Maxon® group was nearly identical (27.1 N ± SD 7.4 and 29.7 N ± SD 9.6, respectively).

Conclusions

We were unable to identify a significant difference in breaking strength at the interface between ADM and normal, native fascia when using permanent versus resorbable sutures.
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Metadata
Title
Effect of suture material on tensile strength and complication rate in abdominal fascial defects repaired with acellular dermal matrix
Authors
A. A. Winkler
M. L. Milburn
L. T. Holton III
N. H. Goldberg
R. P. Silverman
Publication date
01-02-2008
Publisher
Springer-Verlag
Published in
Hernia / Issue 1/2008
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI
https://doi.org/10.1007/s10029-007-0274-8

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