Skip to main content
Top
Published in: Nutrition Journal 1/2012

Open Access 01-12-2012 | Research

Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial

Authors: Leah T Coles, Peter M Clifton

Published in: Nutrition Journal | Issue 1/2012

Login to get access

Abstract

Background

The consumption of beetroot juice on a low nitrate diet may lower blood pressure (BP) and therefore reduce the risk of cardiovascular events. However, it is unknown if its inclusion as part of a normal diet has a similar effect on BP. The aim of the study was to conduct a randomized controlled trial with free-living adults to investigate if consuming beetroot juice in addition to a normal diet produces a measureable reduction in BP.

Method

Fifteen women and fifteen men participated in a double-blind, randomized, placebo-controlled, crossover study. Volunteers were randomized to receive 500 g of beetroot and apple juice (BJ) or a placebo juice (PL). Volunteers had BP measured at baseline and at least hourly for 24-h following juice consumption using an ambulatory blood pressure monitor (ABPM). Volunteers remained at the clinic for 1-h before resuming normal non-strenuous daily activities. The identical procedure was repeated 2-wk later with the drink (BJ or PL) not consumed on the first visit.

Results

Overall, there was a trend (P=0.064) to lower systolic blood pressure (SBP) at 6-h after drinking BJ relative to PL. Analysis in men only (n=13) after adjustment for baseline differences demonstrated a significant (P<0.05) reduction in SBP of 4 – 5 mmHg at 6-h after drinking BJ.

Conclusions

Beetroot juice will lower BP in men when consumed as part of a normal diet in free-living healthy adults.

Trial registration

anzctr.org.au ACTRN12612000445875
Literature
1.
go back to reference Gilchrist M, Shore AC, Benjamin N: Inorganic nitrate and nitrite and control of blood pressure. Cardiovasc Res. 2011, 89: 492-498. 10.1093/cvr/cvq309.CrossRefPubMed Gilchrist M, Shore AC, Benjamin N: Inorganic nitrate and nitrite and control of blood pressure. Cardiovasc Res. 2011, 89: 492-498. 10.1093/cvr/cvq309.CrossRefPubMed
2.
go back to reference van Velzen AG, Sips AJ, Schothorst RC, Lambers AC, Meulenbelt J: The oral bioavailability of nitrate from nitrate-rich vegetables in humans. Toxicol Lett. 2008, 181: 177-181. 10.1016/j.toxlet.2008.07.019.CrossRefPubMed van Velzen AG, Sips AJ, Schothorst RC, Lambers AC, Meulenbelt J: The oral bioavailability of nitrate from nitrate-rich vegetables in humans. Toxicol Lett. 2008, 181: 177-181. 10.1016/j.toxlet.2008.07.019.CrossRefPubMed
3.
go back to reference Lundberg JO, Weitzberg E, Lundberg JM, Alving K: Intragastric nitric oxide production in humans: measurements in expelled air. Gut. 1994, 35: 1543-1546. 10.1136/gut.35.11.1543.CrossRefPubMedPubMedCentral Lundberg JO, Weitzberg E, Lundberg JM, Alving K: Intragastric nitric oxide production in humans: measurements in expelled air. Gut. 1994, 35: 1543-1546. 10.1136/gut.35.11.1543.CrossRefPubMedPubMedCentral
4.
go back to reference Benjamin N, O'Driscoll F, Dougall H, Duncan C, Smith L, Golden M, McKenzie H: Stomach NO synthesis. Nature. 1994, 368: 502-CrossRefPubMed Benjamin N, O'Driscoll F, Dougall H, Duncan C, Smith L, Golden M, McKenzie H: Stomach NO synthesis. Nature. 1994, 368: 502-CrossRefPubMed
5.
go back to reference Lundberg JO, Govoni M: Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med. 2004, 37: 395-400. 10.1016/j.freeradbiomed.2004.04.027.CrossRefPubMed Lundberg JO, Govoni M: Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med. 2004, 37: 395-400. 10.1016/j.freeradbiomed.2004.04.027.CrossRefPubMed
6.
go back to reference Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, et al: Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med. 2003, 9: 1498-1505. 10.1038/nm954.CrossRefPubMed Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, et al: Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med. 2003, 9: 1498-1505. 10.1038/nm954.CrossRefPubMed
7.
go back to reference Ignarro LG: Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J Physiol Pharmacol. 2002, 53: 503-514.PubMed Ignarro LG: Nitric oxide as a unique signaling molecule in the vascular system: a historical overview. J Physiol Pharmacol. 2002, 53: 503-514.PubMed
8.
go back to reference Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, et al: Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008, 51: 784-790. 10.1161/HYPERTENSIONAHA.107.103523.CrossRefPubMedPubMedCentral Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, et al: Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008, 51: 784-790. 10.1161/HYPERTENSIONAHA.107.103523.CrossRefPubMedPubMedCentral
9.
go back to reference Ysart G, Miller P, Barrett G, Farrington D, Lawrance P, Harrison N: Dietary exposures to nitrate in the UK. Food Addit Contam. 1999, 16: 521-532. 10.1080/026520399283669.CrossRefPubMed Ysart G, Miller P, Barrett G, Farrington D, Lawrance P, Harrison N: Dietary exposures to nitrate in the UK. Food Addit Contam. 1999, 16: 521-532. 10.1080/026520399283669.CrossRefPubMed
10.
go back to reference Hord NG, Tang Y, Bryan NS: Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009, 90: 1-10. 10.3945/ajcn.2008.27131.CrossRefPubMed Hord NG, Tang Y, Bryan NS: Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009, 90: 1-10. 10.3945/ajcn.2008.27131.CrossRefPubMed
11.
go back to reference Santamaria P: Nitrate in vegetables: toxicity, content, intake and EC regulation. J Sci Food Agric. 2006, 86: 10-17. 10.1002/jsfa.2351.CrossRef Santamaria P: Nitrate in vegetables: toxicity, content, intake and EC regulation. J Sci Food Agric. 2006, 86: 10-17. 10.1002/jsfa.2351.CrossRef
12.
go back to reference Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett WC: The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease. Ann Intern Med. 2001, 134: 1106-1114.CrossRefPubMed Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett WC: The Effect of Fruit and Vegetable Intake on Risk for Coronary Heart Disease. Ann Intern Med. 2001, 134: 1106-1114.CrossRefPubMed
13.
go back to reference Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D, Willett WC: Fruit and vegetable intake in relation to risk of ischemic stroke. J Am Med Assoc. 1999, 282: 1233-1239. 10.1001/jama.282.13.1233.CrossRef Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D, Willett WC: Fruit and vegetable intake in relation to risk of ischemic stroke. J Am Med Assoc. 1999, 282: 1233-1239. 10.1001/jama.282.13.1233.CrossRef
14.
go back to reference L'Hirondel JL: Nitrate and man. Toxic, harmless or beneficial. 2001, Wallingford, United Kingdom: CABI PublishingCrossRef L'Hirondel JL: Nitrate and man. Toxic, harmless or beneficial. 2001, Wallingford, United Kingdom: CABI PublishingCrossRef
15.
go back to reference Lundberg JO, Feelisch M, Bjorne H, Jansson EA, Weitzberg E: Cardioprotective effects of vegetables: is nitrate the answer?. Nitric Oxide. 2006, 15: 359-362. 10.1016/j.niox.2006.01.013.CrossRefPubMed Lundberg JO, Feelisch M, Bjorne H, Jansson EA, Weitzberg E: Cardioprotective effects of vegetables: is nitrate the answer?. Nitric Oxide. 2006, 15: 359-362. 10.1016/j.niox.2006.01.013.CrossRefPubMed
16.
go back to reference McKnight GM, Duncan CW, Leifert C, Golden MH: Dietary nitrate in man: friend or foe?. Br J Nutr. 1999, 81: 349-358. 10.1017/S000711459900063X.CrossRefPubMed McKnight GM, Duncan CW, Leifert C, Golden MH: Dietary nitrate in man: friend or foe?. Br J Nutr. 1999, 81: 349-358. 10.1017/S000711459900063X.CrossRefPubMed
17.
go back to reference Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, Tarr J, Benjamin N, Jones AM: Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol. 2009, 107: 1144-1155. 10.1152/japplphysiol.00722.2009.CrossRefPubMed Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, Tarr J, Benjamin N, Jones AM: Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol. 2009, 107: 1144-1155. 10.1152/japplphysiol.00722.2009.CrossRefPubMed
18.
go back to reference Hobbs DA, Kaffa N, George TW, Methven L, Lovegrove JA: Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched breads in normotensive male subjects. Br J Nutr. 2012, 14: 1-9. Hobbs DA, Kaffa N, George TW, Methven L, Lovegrove JA: Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched breads in normotensive male subjects. Br J Nutr. 2012, 14: 1-9.
19.
go back to reference Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, et al: Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension. 2010, 56: 274-281. 10.1161/HYPERTENSIONAHA.110.153536.CrossRefPubMed Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, et al: Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension. 2010, 56: 274-281. 10.1161/HYPERTENSIONAHA.110.153536.CrossRefPubMed
20.
go back to reference Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, Benjamin N, Winyard PG, Jones AM: Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010, 299: R1121-R1131. 10.1152/ajpregu.00206.2010.CrossRefPubMed Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, Benjamin N, Winyard PG, Jones AM: Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010, 299: R1121-R1131. 10.1152/ajpregu.00206.2010.CrossRefPubMed
21.
go back to reference Hodgson JM, Puddey IB, Burke V, Beilin LJ, Jordan N: Effects on blood pressure of drinking green and black tea. J Hypertens. 1999, 17: 457-463. 10.1097/00004872-199917040-00002.CrossRefPubMed Hodgson JM, Puddey IB, Burke V, Beilin LJ, Jordan N: Effects on blood pressure of drinking green and black tea. J Hypertens. 1999, 17: 457-463. 10.1097/00004872-199917040-00002.CrossRefPubMed
22.
go back to reference Puddey IB, Beilin LJ: Alcohol is bad for blood pressure. Clin Exp Pharmacol Physiol. 2006, 33: 847-852. 10.1111/j.1440-1681.2006.04452.x.CrossRefPubMed Puddey IB, Beilin LJ: Alcohol is bad for blood pressure. Clin Exp Pharmacol Physiol. 2006, 33: 847-852. 10.1111/j.1440-1681.2006.04452.x.CrossRefPubMed
23.
go back to reference Zhang Z, Hu G, Caballero B, Appel L, Chen L: Habitual coffee consumption and risk of hypertension: a systematic review and meta-analysis of prospective observational studies. Am J Clin Nutr. 2011, 93: 1212-1219. 10.3945/ajcn.110.004044.CrossRefPubMed Zhang Z, Hu G, Caballero B, Appel L, Chen L: Habitual coffee consumption and risk of hypertension: a systematic review and meta-analysis of prospective observational studies. Am J Clin Nutr. 2011, 93: 1212-1219. 10.3945/ajcn.110.004044.CrossRefPubMed
24.
go back to reference Larson AJ, Symons JD, Jalili T: Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Adv Nutr. 2012, 3: 49-46.CrossRef Larson AJ, Symons JD, Jalili T: Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms. Adv Nutr. 2012, 3: 49-46.CrossRef
25.
go back to reference Staessen JA, Wang JG, Thijs L: Cardiovascular protection and blood pressure reduction: a meta-analysis. Lancet. 2001, 358: 1305-1315. 10.1016/S0140-6736(01)06411-X.CrossRefPubMed Staessen JA, Wang JG, Thijs L: Cardiovascular protection and blood pressure reduction: a meta-analysis. Lancet. 2001, 358: 1305-1315. 10.1016/S0140-6736(01)06411-X.CrossRefPubMed
Metadata
Title
Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial
Authors
Leah T Coles
Peter M Clifton
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Nutrition Journal / Issue 1/2012
Electronic ISSN: 1475-2891
DOI
https://doi.org/10.1186/1475-2891-11-106

Other articles of this Issue 1/2012

Nutrition Journal 1/2012 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.