Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Endocrine
Published in: Endocrine 2/2017

01-08-2017 | Original Article

Effect of aerobic interval training on serum IL-10, TNFα, and adipokines levels in women with multiple sclerosis: possible relations with fatigue and quality of life

Authors: Motahare Mokhtarzade, Rouholah Ranjbar, Nastaran Majdinasab, Darpan Patel, Mehdieh Molanouri Shamsi

Published in: Endocrine | Issue 2/2017

Login to get access

Abstract

Purpose

Multiple sclerosis is associated with immune system dysfunction and chronic inflammation; however, possible relations between immunologic and metabolic factors and some psychological indexes such as fatigue and quality of life, especially in relation to exercise training, have not yet been investigated. The present study was designed to investigate the effect of aerobic interval training on interleukin-10/tumor necrosis factor ratio and adipokine (leptin and adiponectin) concentrations in women with multiple sclerosis. Furthermore, the relationship between these factors with fatigue and quality of life were assessed.

Methods

Forty women with multiple sclerosis (Expanded Disability Status Scale ≤3) were randomized into either a non-exercising control or training group. The training group performed 8-weeks of upper and lower limb aerobic interval training. Serum concentrations of tumor necrosis factorα, interleukin-10, leptin, and adiponectin were measured before and after the 8-week intervention. Moreover, antropometric measures and measures for fatigue and quality of life were determined at the onset of and after exercise training.

Results

The results revealed that leptin and tumor necrosis factorα levels significantly decreased subsequent to the aerobic interval training. Although blood adiponectin levels considerably increased in the training group, interleukin-10 and interleukin-10/tumor necrosis factorα ratio underwent no substantial change after the exercise training. In addition, the aerobic interval training was associated with improvement in fatigue, quality of life, and maximal oxygen consumption.

Conclusions

Our findings suggested that aerobic interval training can be an effective strategy for managing the immune system at least by its significant impact on inflammatory cytokines and adipokines levels in women with multiple sclerosis. Additionally, this positive impact improved fatigue and adipose tissue indicators.
Literature
1.
L.J. White, R.H. Dressendorfer, Exercise and multiple sclerosis. Sports Med. 34(15), 1077–1100 (2004)CrossRefPubMed
2.
M.W. Koch, Epidemiology and natural history of multiple sclerosis. Mult Scler Relat Disord, 21 21–25 (2013)
3.
O. Kantarci, D. Wingerchuk, Epidemiology and natural history of multiple sclerosis: new insights. Curr. Opin. Neurol. 19(3), 248–254 (2006)CrossRefPubMed
4.
5.
E. Kingwell, J.J. Marriott, N. Jetté, T. Pringsheim, N. Makhani, S.A. Morrow, J.D. Fisk, C. Evans, S.G. Béland, S. Kulaga, J. Dykeman, Incidence and prevalence of multiple sclerosis in Europe: a systematic review. BMC Neurol. 13(1), 128 (2013)CrossRefPubMedPubMedCentral
6.
H. Alvarenga-Filho, P.M. Sacramento, T.B. Ferreira, J. Hygino, J.E.C. Abreu, S.R. Carvalho, A.C. Wing, R.M.P. Alvarenga, C.A. Bento, Combined exercise training reduces fatigue and modulates the cytokine profile of T-cells from multiple sclerosis patients in response to neuromediators. J. Neuroimmunol. 293, 91–99 (2016)CrossRefPubMed
7.
R.E. Klaren, R.W. Motl, D. Dlugonski, B.M. Sandroff, L.A. Pilutti, Objectively quantified physical activity in persons with multiple sclerosis. Arch. Phys. Med. Rehabil. 94(12), 2342–2348 (2013)CrossRefPubMed
8.
B.M. Sandroff, D. Dlugonski, M. Weikert, Y. Suh, S. Balantrapu, R.W. Motl, Physical activity and multiple sclerosis: new insights regarding inactivity. Acta Neurol. Scand. 126(4), 256–262 (2012)CrossRefPubMed
9.
M. Kierkegaard, I.E. Lundberg, T. Olsson, S. Johansson, S. Ygberg, C. Opava, L.W. Holmqvist, F. Piehl, High-intensity resistance training in multiple sclerosis—An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition. J. Neurol. Sci. 362, 251–257 (2016)CrossRefPubMed
10.
A.K. Andreasen, E. Stenager, U. Dalgas, The effect of exercise therapy on fatigue in multiple sclerosis. Mult. Scler. 17(9), 1041–1054 (2011)CrossRefPubMed
11.
J. Brisswalter, M. Collardeau, A. René, Effects of acute physical exercise characteristics on cognitive performance. Sports Med. 32(9), 555–566 (2002)CrossRefPubMed
12.
V. Castellano, D.I. Patel, L.J. White, Cytokine responses to acute and chronic exercise in multiple sclerosis. J. Appl. Physiol. 104(6), 1697–1702 (2008)CrossRefPubMed
13.
N. Deckx, I. Wens, A.H. Nuyts, N. Hens, B.Y. De Winter, G. Koppen, H. Goossens, P. Van Damme, Z.N. Berneman, B.O., Eijnde, N. Cools, 12 weeks of combined endurance and resistance training reduces innate markers of inflammation in a randomized controlled clinical trial in patients with multiple sclerosis. Mediat. Inflamm. 2016:6789276 (2016)
14.
T. Kjølhede, U. Dalgas, A.B. Gade, M. Bjerre, E. Stenager, T. Petersen, K. Vissing, Acute and chronic cytokine responses to resistance exercise and training in people with multiple sclerosis. Scand. J. Med. Sci. Sports 26(7), 824–834 (2015)
15.
Z. Golzari, F. Shabkhiz, S. Soudi, M.R. Kordi, S.M. Hashemi, Combined exercise training reduces IFN-γ and IL-17 levels in the plasma and the supernatant of peripheral blood mononuclear cells in women with multiple sclerosis. Int. Immunopharmacol. 10(11), 1415–1419 (2010)CrossRefPubMed
16.
L.J. White, V. Castellano, S.C. Mc Coy, Cytokine responses to resistance training in people with multiple sclerosis. J. Sports Sci. 24(8), 911–914 (2006)CrossRefPubMed
17.
P. Flachenecker, I. Bihler, F. Weber, M. Gottschalk, K.V. Toyka, P. Rieckmann, Cytokine mRNA expression in patients with multiple sclerosis and fatigue. Mult. Scler. 10(2), 165–169 (2004)CrossRefPubMed
18.
G. Frisullo, M. Mirabella, F. Angelucci, M. Caggiula, R. Morosetti, C. Sancricca, A.K. Patanella, V. Nociti, R. Iorio, A. Bianco, V. Tomassini, The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing–remitting multiple sclerosis. J. Neuroimmunol. 192(1), 174–183 (2007)CrossRefPubMed
19.
L. Kraszula, A. Jasińska, M.O. Eusebio, P. Kuna, A. Głąbiński, M. Pietruczuk, Evaluation of the relationship between leptin, resistin, adiponectin and natural regulatory T cells in relapsing-remitting multiple sclerosis. Neurol. Neurochir. Pol. 46(1), 22–28 (2012)PubMed
20.
E. Toussirot, D. Binda, C. Gueugnon, G. Dumoulin, Adiponectin in autoimmune diseases. Curr. Med. Chem. 19(32), 5474–5480 (2012)CrossRefPubMed
21.
H.K. Park, R.S. Ahima, Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism 64(1), 24–34 (2015)CrossRefPubMed
22.
V. Lafrance, W. Inoue, B. Kan, G.N. Luheshi, Leptin modulates cell morphology and cytokine release in microglia. Brain Behav. Immun. 24(3), 358–365 (2014)CrossRef
23.
H. Tilg, A.R. Moschen, Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat. Rev. Immunol. 6(10), 772–783 (2006)CrossRefPubMed
24.
E.A. Stringer, K.S. Baker, I.R. Carroll, J.G. Montoya, L. Chu, H.T. Maecker, J.W. Younger, Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology. J. Transl. Med. 11(1), 93 (2013)CrossRefPubMedPubMedCentral
25.
A.S. Jackson, M.L. Pollock, A.N.N. Ward, Generalized equations for predicting body density of women. Med. Sci. Sports Exerc. 12(3), 175–181 (1979)
26.
W.E. Siri, Body composition from fluid spaces and density: analysis of methods. Tech Meas Body Compos 61, 223–244 (1961)
27.
K. Hajian-Tilaki, B. Heidari, Prevalences of overweight and obesity and their association with physical activity pattern among Iranian adolescents aged 12–17 years. Public Health Nutr. 15(12), 2246–2252 (2012)CrossRefPubMed
28.
H. Ghaem, A.B. Haghighi, P. Jafari, A.R. Nikseresht, Validity and reliability of the Persian version of the multiple sclerosis quality of life questionnaire. Neurol. India 55(4), 369 (2007)CrossRefPubMed
29.
M. Azimian, A. Shahvarughi Farahani, A. Dadkhah, M. Fallahpour, M. Karimlu, Fatigue severity scale: the psychometric properties of the Persian-version in patients with multiple sclerosis. Res. J. Biol. Sci 4(9), 974–977 (2009)
30.
T.W. Storer, A.J. Davis, V.J. Caiozzo, Accurate prediction of VO2max in cycle ergometry. Med. Sci. Sports Exerc. 22(5), 704–712 (1990)CrossRefPubMed
31.
M.N. Sawka, M.E. Foley, N.A. Pimental, M.M. Toner, K.B. Pandolf, Determination of maximal aerobic power during upper-body exercise. J. Appl. Physiol. 54(1), 113–117 (1983)PubMed
32.
P. López-Jaramillo, D. Gómez-Arbeláez, J. López-López, C. López-López, J. Martínez-Ortega, A. Gómez-Rodríguez, S. Triana-Cubillos, The role of leptin/adiponectin ratio in metabolic syndrome and diabetes. Horm. Mol. Biol. Clin. Investig. 18(1), 37–45 (2014)PubMed
33.
M.M. Shamsi, S. Chekachak, S. Soudi, L.S. Quinn, K. Rangbar, J. Chenari, M.H. Yazdi, M. Mahdavi, Combined effect of aerobic interval training and selenium nanoparticles on expression of IL-15 and IL-10/TNF-α ratio in skeletal muscle of 4T1 breast cancer mice with cachexia. Cytokine 90, 100–108 (2017)CrossRef
34.
M.B. Rietberg, D. Brooks, B.M. Uitdehaag, G. Kwakkel, Exercise therapy for multiple sclerosis. Cochrane Libr. 1, 1–33 (2005)
35.
M. Roppolo, A. Mulasso, M. Gollin, A. Bertolotto, S. Ciairano, The role of fatigue in the associations between exercise and psychological health in multiple sclerosis: direct and indirect effects. Ment. Health Phys. Act 6(2), 87–94 (2013)CrossRef
36.
M. Langeskov-Christensen, M. Heine, G. Kwakkel, U. Dalgas, Aerobic capacity in persons with multiple sclerosis: a systematic review and meta-analysis. Sports Med. 45(6), 905–923 (2015)CrossRefPubMed
37.
J.A. Ponichtera‐Mulcare, T. Mathews, P.J. Barrett, S.C. Gupta, Change in aerobic fitness of patients with multiple sclerosis during a 6‐month training program. Res. Sports Med. 7(3–4), 265–272 (1997)
38.
C. Heesen, L. Nawrath, C. Reich, N. Bauer, K.H. Schulz, S.M. Gold, Fatigue in multiple sclerosis: an example of cytokine mediated sickness behaviour? J. Neurol. Neurosurg. Psychiatry. 77(1), 34–39 (2006)CrossRefPubMedPubMedCentral
39.
S. Lindquist, S. Hassinger, J.A. Lindquist, M. Sailer, The balance of pro-inflammatory and trophic factors in multiple sclerosis patients: effects of acute relapse and immunomodulatory treatment. Mult. Scler. 17(7), 851–866 (2011)CrossRefPubMed
40.
N. Satoh, M. Naruse, T. Usui, T. Tagami, T. Suganami, K. Yamada, H. Kuzuya, A. Shimatsu, Y. Ogawa, Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients. Diabetes Care 27(10), 2488–2490 (2004)CrossRefPubMed
41.
S. Dimitrov, E. Hulteng, S. Hong, Inflammation and exercise: inhibition of monocytic TNF production by acute exercise via β 2-adrenergic activation. Brain Behav. Immun. 61, 60–68 (2017)
42.
H.A. Arnett, J. Mason, M. Marino, K. Suzuki, G.K. Matsushima, J.P.Y. Ting, TNFα promotes proliferation of oligodendrocyte progenitors and remyelination. Nat. Neurosci. 4(11), 1116–1122 (2001)CrossRefPubMed
43.
J.J. Peschon, D.S. Torrance, K.L. Stocking, M.B. Glaccum, C. Otten, C.R. Willis, K. Charrier, P.J. Morrissey, C.B. Ware, K.M. Mohler, TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J. Immunol. 160(2), 943–952 (1998)PubMed
44.
S.H. Jung, H.S. Park, H.S. Kim, W.H. Choi, C.W. Ahn, B.T. Kim, S.M. Kim, S.Y. Lee, S.M. Ahn, Y.K. Kim, H.J. Kim, Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss. J. Nutr. Biochem. 19(6), 371–375 (2008)CrossRefPubMed
45.
D. Markovitch, R.M. Tyrrell, D. Thompson, Acute moderate-intensity exercise in middle-aged men has neither an anti-nor proinflammatory effect. J. Appl. Physiol. 105(1), 260–265 (2008)CrossRefPubMedPubMedCentral
46.
A.K. Hedström, T. Olsson, L. Alfredsson, High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult. Scler. 18(9), 1334–1336 (2012)CrossRefPubMed
47.
48.
K.L. Munger, J. Bentzen, B. Laursen, E. Stenager, N. Koch-Henriksen, T.I. Sørensen, J.L. Baker, Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Multi. Scler. 19, 13524585–13524589 (2013)
49.
R.F. Kushner, Weight loss strategies for treatment of obesity. Prog. Cardiovasc. Dis. 56(4), 465–472 (2014)CrossRefPubMed
50.
M. Matsubara, S. Maruoka, S. Katayose, Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women. Euro. J. Endocrinol. 147(2), 173–180 (2002)CrossRef
51.
E. Eftekhari, M. Etemadifar, A. Ebrahimi, S. Baradaran, The relation between peptide hormones and sex hormone in patients with multiple sclerosis. Iran. J. Neurol 12(2), 60 (2013)PubMedPubMedCentral
52.
G. Matarese, C. Procaccini, V. De Rosa, The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis? J. Leukoc. Biol. 84(4), 893–899 (2008)CrossRefPubMed
53.
A. Ebrahimi, E. Eftekhari, M. Etemadifar, Effects of whole body vibration on hormonal & functional indices in patients with multiple sclerosis. Indian J. Med. Res 142(4), 450–460 (2015)CrossRefPubMedPubMedCentral
54.
U. Dalgas, E. Stenager, Exercise and disease progression in multiple sclerosis: can exercise slow down the progression of multiple sclerosis? Ther. Adv. Neurol. Disord. 5(2), 81–95 (2012)CrossRefPubMedPubMedCentral
Metadata
Title
Effect of aerobic interval training on serum IL-10, TNFα, and adipokines levels in women with multiple sclerosis: possible relations with fatigue and quality of life
Authors
Motahare Mokhtarzade
Rouholah Ranjbar
Nastaran Majdinasab
Darpan Patel
Mehdieh Molanouri Shamsi
Publication date
01-08-2017
Publisher
Springer US
Published in
Endocrine / Issue 2/2017
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-017-1337-y

Other articles of this Issue 2/2017

Endocrine 2/2017 Go to the issue

Original Article

Dopamine D2 receptor expression in the corticotroph cells of the human normal pituitary gland

Original Article

Hypothalamo-pituitary-adrenal axis after a single epidural triamcinolone injection

Original Article

Associations of aldosterone and renin concentrations with inflammation—the Study of Health in Pomerania and the German Conn’s Registry

Letter to the Editor

The “broken chair” in patients with differentiated thyroid cancer

Research Letter

A permissive role of growth hormone (GH) in the development of second brain tumors after radiotherapy?

Original Article

Natural history of graves’ orbitopathy after treatment
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits