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Published in: BMC Public Health 1/2015

Open Access 01-12-2015 | Study protocol

Effect of a program of short bouts of exercise on bone health in adolescents involved in different sports: the PRO-BONE study protocol

Authors: Dimitris Vlachopoulos, Alan R Barker, Craig A Williams, Karen M Knapp, Brad S Metcalf, Luis Gracia-Marco

Published in: BMC Public Health | Issue 1/2015

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Abstract

Background

Osteoporosis is a skeletal disease associated with high morbidity, mortality and increased economic costs. Early prevention during adolescence appears to be one of the most beneficial practices. Exercise is an effective approach for developing bone mass during puberty, but some sports may have a positive or negative impact on bone mass accrual. Plyometric jump training has been suggested as a type of exercise that can augment bone, but its effects on adolescent bone mass have not been rigorously assessed. The aims of the PRO-BONE study are to: 1) longitudinally assess bone health and its metabolism in adolescents engaged in osteogenic (football), non-osteogenic (cycling and swimming) sports and in a control group, and 2) examine the effect of a 9 month plyometric jump training programme on bone related outcomes in the sport groups.

Methods/Design

This study will recruit 105 males aged 12–14 years who have participated in sport specific training for at least 3 hours per week during the last 3 years in the following sports groups: football (n = 30), cycling (n = 30) and swimming (n = 30). An age-matched control group (n = 15) that does not engage in these sports more than 3 hours per week will also be recruited. Participants will be measured on 5 occasions: 1) at baseline; 2) after 12 months of sport specific training where each sport group will be randomly allocated into two sub-groups: intervention group (sport + plyometric jump training) and sport group (sport only); 3) exactly after the 9 months of intervention; 4) 6 months following the intervention; 5) 12 months following the intervention. Body composition (dual energy X-ray absorptiometry, air displacement plethysmography and bioelectrical impedance), bone stiffness index (ultrasounds), physical activity (accelerometers), diet (24 h recall questionnaire), pubertal maturation (Tanner stage), physical fitness (cardiorespiratory and muscular), bone turnover markers and vitamin D will be measured at each visit.

Discussion

The PRO-BONE study is designed to investigate the impact of osteogenic and non-osteogenic sports on bone development in adolescent males during puberty, and how a plyometric jump training programme is associated with body composition parameters.
Literature
1.
Kanis JA, Johnell O. Requirements for DXA for the management of osteoporosis in Europe. Osteoporos Int. 2005;16(3):229–38.CrossRefPubMed
2.
Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, et al. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008;19(4):399–428.CrossRefPubMedPubMedCentral
3.
Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17(12):1726–33.CrossRefPubMed
4.
Gafni RI, Baron J. Childhood bone mass acquisition and peak bone mass may not be important determinants of bone mass in late adulthood. Pediatrics. 2007;119 Suppl 2:S131–6.CrossRefPubMed
5.
Rizzoli R, Bianchi ML, Garabedian M, McKay HA, Moreno LA. Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. Bone. 2010;46(2):294–305.CrossRefPubMed
6.
Baxter-Jones AD, Faulkner RA, Forwood MR, Mirwald RL, Bailey DA. Bone mineral accrual from 8 to 30 years of age: an estimation of peak bone mass. J Bone Miner Res. 2011;26(8):1729–39.CrossRefPubMed
7.
8.
Perez-Lopez FR, Chedraui P, Cuadros-Lopez JL. Bone mass gain during puberty and adolescence: deconstructing gender characteristics. Curr Med Chem. 2010;17(5):453–66.CrossRefPubMed
9.
Baroncelli GI, Bertelloni S, Sodini F, Saggese G. Osteoporosis in children and adolescents: etiology and management. Paediatr Drugs. 2005;7(5):295–323.CrossRefPubMed
10.
Henry YM, Fatayerji D, Eastell R. Attainment of peak bone mass at the lumbar spine, femoral neck and radius in men and women: relative contributions of bone size and volumetric bone mineral density. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2004;15(4):263–73.CrossRef
11.
Zofkova I. Role of genetics in prediction of osteoporosis risk. Vnitr Lek. 2011;57(1):78–84.PubMed
12.
Branca F, Valtuena S. Calcium, physical activity and bone health–building bones for a stronger future. Public Health Nutr. 2001;4(1A):117–23.CrossRefPubMed
13.
Vicente-Rodriguez G, Ezquerra J, Mesana MI, Fernandez-Alvira JM, Rey-Lopez JP, Casajus JA, et al. Independent and combined effect of nutrition and exercise on bone mass development. J Bone Miner Metab. 2008;26(5):416–24.CrossRefPubMed
14.
Valtuena J, Gracia-Marco L, Vicente-Rodriguez G, Gonzalez-Gross M, Huybrechts I, Rey-Lopez JP, et al. Vitamin D status and physical activity interact to improve bone mass in adolescents. Osteoporos Int: The HELENA Study; 2012.
15.
Vicente-Rodriguez G. How does exercise affect bone development during growth? Sports Med. 2006;36(7):561–9.CrossRefPubMed
16.
Boreham CA, McKay HA. Physical activity in childhood and bone health. Br J Sports Med. 2011;45(11):877–9.CrossRefPubMed
17.
Gracia-Marco L, Moreno LA, Ortega FB, Leon F, Sioen I, Kafatos A, et al. Levels of physical activity that predict optimal bone mass in adolescents the HELENA study. Am J Prev Med. 2011;40(6):599–607.CrossRefPubMed
18.
Heinonen A: Biomechanics. In., 1st edn. Edited by Khan K; McKay H; Kannus P et al.: Champaign (IL). Physical activity and bone health: Human Kinetics; 2001: 23–34.
19.
Gustavsson A, Thorsen K, Nordstrom P. A 3-year longitudinal study of the effect of physical activity on the accrual of bone mineral density in healthy adolescent males. Calcified Tissue Int. 2003;73(2):108–14.CrossRef
20.
DA Bailey MH, Mirwald RL, Crocker PR, Faulkner RA. A six year longitudinal study of the relationship of PA to BMAccrual in growing children.pdf> J Bone Miner Res. 1999;14(10):1672–9.CrossRefPubMed
21.
Baxter-Jones AD, Kontulainen SA, Faulkner RA, Bailey DA. A longitudinal study of the relationship of physical activity to bone mineral accrual from adolescence to young adulthood. Bone. 2008;43(6):1101–7.CrossRefPubMed
22.
Uzunca K, Birtane M, Durmus-Altun G, Ustun F. High bone mineral density in loaded skeletal regions of former professional football (soccer) players: what is the effect of time after active career? Br J Sports Med. 2005;39(3):154–7.CrossRefPubMedPubMedCentral
23.
Bradney M, Pearce G, Naughton G, Sullivan C, Bass S, Beck T, et al. Moderate exercise during growth in prepubertal boys: changes in bone mass, size, volumetric density, and bone strength: a controlled prospective study. J Bone Miner Res. 1998;13(12):1814–21.CrossRefPubMed
24.
Wolff I, van Croonenborg JJ, Kemper HC, Kostense PJ, Twisk JW. The effect of exercise training programs on bone mass: a meta-analysis of published controlled trials in pre- and postmenopausal women. Osteoporos Int. 1999;9(1):1–12.CrossRefPubMed
25.
26.
Krustrup P, Dvorak J, Junge A, Bangsbo J. Executive summary: the health and fitness benefits of regular participation in small-sided football games. Scand J Med Sci Sports. 2010;20 Suppl 1:132–5.CrossRefPubMed
27.
Ara I, Vicente-Rodriguez G, Perez-Gomez J, Jimenez-Ramirez J, Serrano-Sanchez JA, Dorado C, et al. Influence of extracurricular sport activities on body composition and physical fitness in boys: a 3-year longitudinal study. Int J Obes (Lond). 2006;30(7):1062–71.CrossRef
28.
Vicente-Rodriguez G, Ara I, Perez-Gomez J, Serrano-Sanchez JA, Dorado C, Calbet JA. High femoral bone mineral density accretion in prepubertal soccer players. Med Sci Sports Exerc. 2004;36(10):1789–95.CrossRefPubMed
29.
Krustrup P, Hansen PR, Andersen LJ, Jakobsen MD, Sundstrup E, Randers MB, et al. Long-term musculoskeletal and cardiac health effects of recreational football and running for premenopausal women. Scand J Med Sci Sports. 2010;20 Suppl 1:58–71.CrossRefPubMed
30.
Calbet JA, Dorado C, Diaz-Herrera P, Rodriguez-Rodriguez LP. High femoral bone mineral content and density in male football (soccer) players. Med Sci Sports Exerc. 2001;33(10):1682–7.CrossRefPubMed
31.
Rico H, Revilla M, Villa LF, Gomez-Castresana F, Alvarez del Buergo M. Body composition in postpubertal boy cyclists. J Sports Med Phys Fitness. 1993;33(3):278–81.PubMed
32.
Stewart AD, Hannan J. Total and regional bone density in male runners, cyclists, and controls. Med Sci Sports Exerc. 2000;32(8):1373–7.CrossRefPubMed
33.
Duncan CS, Blimkie CJ, Cowell CT, Burke ST, Briody JN, Howman-Giles R. Bone mineral density in adolescent female athletes: relationship to exercise type and muscle strength. Med Sci Sports Exerc. 2002;34(2):286–94.CrossRefPubMed
34.
Duncan CS, Blimkie CJ, Kemp A, Higgs W, Cowell CT, Woodhead H, et al. Mid-femur geometry and biomechanical properties in 15- to 18-yr-old female athletes. Med Sci Sports Exerc. 2002;34(4):673–81.PubMed
35.
Warner SE, Shaw JM, Dalsky GP. Bone mineral density of competitive male mountain and road cyclists. Bone. 2002;30(1):281–6.CrossRefPubMed
36.
Nichols JF, Palmer JE, Levy SS. Low bone mineral density in highly trained male master cyclists. Osteoporos Int. 2003;14(8):644–9.CrossRefPubMed
37.
Barry DW, Kohrt WM. BMD decreases over the course of a year in competitive male cyclists. J Bone Miner Res. 2008;23(4):484–91.CrossRefPubMed
38.
Rector RS, Rogers R, Ruebel M, Hinton PS. Participation in road cycling vs running is associated with lower bone mineral density in men. Metabolism. 2008;57(2):226–32.CrossRefPubMed
39.
Olmedillas H, Gonzalez-Aguero A, Moreno LA, Casajus JA, Vicente-Rodriguez G. Bone related health status in adolescent cyclists. PLoS One. 2011;6(9):e24841.CrossRefPubMedPubMedCentral
40.
41.
Andreoli A, Celi M, Volpe SL, Sorge R, Tarantino U. Long-term effect of exercise on bone mineral density and body composition in post-menopausal ex-elite athletes: a retrospective study. Eur J Clin Nutr. 2012;66(1):69–74.CrossRefPubMed
42.
Ferry B, Lespessailles E, Rochcongar P, Duclos M, Courteix D. Bone health during late adolescence: effects of an 8-month training program on bone geometry in female athletes. Joint Bone Spine. 2013;80(1):57–63.CrossRefPubMed
43.
Greenway KG, Walkley JW, Rich PA. Does long-term swimming participation have a deleterious effect on the adult female skeleton? Eur J Appl Physiol. 2012;112(9):3217–25.CrossRefPubMed
44.
Ferry B, Duclos M, Burt L, Therre P, Le Gall F, Jaffre C, et al. Bone geometry and strength adaptations to physical constraints inherent in different sports: comparison between elite female soccer players and swimmers. J Bone Miner Metab. 2011;29(3):342–51.CrossRefPubMed
45.
Dias Quiterio AL, Carnero EA, Baptista FM, Sardinha LB. Skeletal mass in adolescent male athletes and nonathletes: relationships with high-impact sports. J Strength Cond Res. 2011;25(12):3439–47.CrossRefPubMed
46.
Tenforde AS, Fredericson M. Influence of sports participation on bone health in the young athlete: a review of the literature. PM R. 2011;3(9):861–7.CrossRefPubMed
47.
Scofield KL, Hecht S. Bone health in endurance athletes: runners, cyclists, and swimmers. Curr Sports Med Rep. 2012;11(6):328–34.CrossRefPubMed
48.
Robling AG, Burr DB, Turner CH. Recovery periods restore mechanosensitivity to dynamically loaded bone. J Exp Biol. 2001;204(Pt 19):3389–99.PubMed
49.
McKay HA, MacLean L, Petit M, MacKelvie-O’Brien K, Janssen P, Beck T, et al. “Bounce at the Bell”: a novel program of short bouts of exercise improves proximal femur bone mass in early pubertal children. Br J Sports Med. 2005;39(8):521–6.CrossRefPubMedPubMedCentral
50.
Mackelvie KJ, McKay HA, Khan KM, Crocker PR. A school-based exercise intervention augments bone mineral accrual in early pubertal girls. J Pediatr. 2001;139(4):501–8.CrossRefPubMed
51.
MacKelvie KJ, Khan KM, Petit MA, Janssen PA, McKay HA. A school-based exercise intervention elicits substantial bone health benefits: a 2-year randomized controlled trial in girls. Pediatrics. 2003;112(6 Pt 1):e447.CrossRefPubMed
52.
Witzke KA, Snow CM. Effects of plyometric jump training on bone mass in adolescent girls. Medicine and science in sports and exercise. 2000;32(6):1051–7.CrossRefPubMed
53.
Jurimae J. Interpretation and application of bone turnover markers in children and adolescents. Curr Opin Pediatr. 2010;22(4):494–500.CrossRefPubMed
54.
Lima F, De Falco V, Baima J, Carazzato JG, Pereira RM. Effect of impact load and active load on bone metabolism and body composition of adolescent athletes. Med Sci Sports Exerc. 2001;33(8):1318–23.CrossRefPubMed
55.
Gracia-Marco L, Ortega FB, Jiménez-Pavón D, Rodríguez G, Valtueña J, Díaz-Marténez ÁE, et al. Contribution of bone turnover markers to bone mass in pubertal boys and girls. J Pediatr Endocrinol Metab. 2011;24:11–2.CrossRef
56.
Gomez-Bruton A, Gonzalez-Aguero A, Gomez-Cabello A, Casajus JA, Vicente-Rodriguez G. Is bone tissue really affected by swimming? a systematic review. PLoS One. 2013;8(8):e70119.CrossRefPubMedPubMedCentral
57.
Stear SJ, Prentice A, Jones SC, Cole TJ. Effect of a calcium and exercise intervention on the bone mineral status of 16-18-y-old adolescent girls. Am J Clin Nutr. 2003;77(4):985–92.PubMed
58.
Valtuena J, Gracia-Marco L, Vicente-Rodriguez G, Gonzalez-Gross M, Huybrechts I, Rey-Lopez JP, et al. Vitamin D status and physical activity interact to improve bone mass in adolescents The HELENA Study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2012;23(8):2227–37.CrossRef
59.
Specker B, Vukovich M. Evidence for an interaction between exercise and nutrition for improved bone health during growth. Med Sport Sci. 2007;51:50–63.CrossRefPubMed
60.
Pettifor JM, Prentice A. The role of vitamin D in paediatric bone health. Best Pract Res Clin Endocrinol Metab. 2011;25(4):573–84.CrossRefPubMed
61.
Constantini NW, Dubnov-Raz G, Chodick G, Rozen GS, Giladi A, Ish-Shalom S. Physical activity and bone mineral density in adolescents with vitamin D deficiency. Med Sci Sport Exer. 2010;42(4):646–50.CrossRef
62.
Bachrach LK, Hastie T, Wang MC, Narasimhan B, Marcus R. Bone mineral acquisition in healthy Asian, Hispanic, black, and Caucasian youth: a longitudinal study. J ClinEndocrinol Metab. 1999;84(12):4702–12.
63.
Tanner JM, Whitehouse RH. Clinical longitudinal standards for height, weight, height velocity, weight velocity, and stages of puberty. Arch Dis Child. 1976;51(3):170–9.CrossRefPubMedPubMedCentral
64.
Ginty F, Rennie KL, Mills L, Stear S, Jones S, Prentice A. Positive, site-specific associations between bone mineral status, fitness, and time spent at high-impact activities in 16-to 18-year-old boys. Bone. 2005;36(1):101–10.CrossRefPubMed
65.
Magkos F, Kavouras SA, Yannakoulia M, Karipidou M, Sidossi S, Sidossis LS. The bone response to non-weight-bearing exercise is sport-, site-, and sex-specific. Clin J Sport Med. 2007;17(2):123–8.CrossRefPubMed
66.
Ishikawa S, Kim Y, Kang M, Morgan DW. Effects of weight-bearing exercise on bone health in girls: a meta-analysis. Sports Med. 2013;43(9):875–92.CrossRefPubMed
67.
Crabtree NJ, Arabi A, Bachrach LK, Fewtrell M, El-Hajj Fuleihan G, Kecskemethy HH, et al. Dual-energy X-ray absorptiometry interpretation and reporting in children and adolescents: the revised 2013 ISCD Pediatric Official Positions. J Clin Densitom. 2014;17(2):225–42.CrossRefPubMed
68.
Damilakis J, Solomou G, Manios GE, Karantanas A. Pediatric radiation dose and risk from bone density measurements using a GE Lunar Prodigy scanner. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 2013;24(7):2025–31.CrossRef
69.
Winsley RJ, Fulford J, MacLeod KM, Ramos-Ibanez N, Williams CA, Armstrong N. Prediction of visceral adipose tissue using air displacement plethysmography in children. Obes Res. 2005;13(12):2048–51.CrossRefPubMed
70.
Elberg J, McDuffie JR, Sebring NG, Salaita C, Keil M, Robotham D, et al. Comparison of methods to assess change in children’s body composition. Am J Clin Nutr. 2004;80(1):64–9.PubMedPubMedCentral
71.
McCrory MA, Gomez TD, Bernauer EM, Mole PA. Evaluation of a new air displacement plethysmograph for measuring human body composition. Med Sci Sports Exerc. 1995;27(12):1686–91.CrossRefPubMed
72.
Siri WE. Body composition from fluid spaces and density: analysis of methods. In: Brozek J, Henschel A, editors. Techniques for measuring body composition. Washington, DC: National Academy of Sciences, National Research Council; 1961. p. 223–34.
73.
Siri WE. Body composition from fluid spaces and density: analysis of methods. 1961. Nutrition. 1993;9(5):480–91. discussion 480, 492.PubMed
74.
Jaworski M, Lebiedowski M, Lorenc RS, Trempe J. Ultrasound bone measurement in pediatric subjects. Calcif Tissue Int. 1995;56(5):368–71.CrossRefPubMed
75.
Baroncelli GI. Quantitative ultrasound methods to assess bone mineral status in children: technical characteristics, performance, and clinical application. Pediatr Res. 2008;63(3):220–8.CrossRefPubMed
76.
Talma H, Chinapaw MJ, Bakker B, HiraSing RA, Terwee CB, Altenburg TM. Bioelectrical impedance analysis to estimate body composition in children and adolescents: a systematic review and evidence appraisal of validity, responsiveness, reliability and measurement error. Obesity reviews: an official journal of the International Association for the Study of Obesity. 2013;14(11):895–905.CrossRef
77.
Wu YT, Nielsen DH, Cassady SL, Cook JS, Janz KF, Hansen JR. Cross-validation of bioelectrical impedance analysis of body composition in children and adolescents. Phys Ther. 1993;73(5):320–8.PubMed
78.
Jurimae J, Maestu J, Jurimae T. Bone turnover markers during pubertal development: relationships with growth factors and adipocytokines. Med Sport Sci. 2010;55:114–27.CrossRefPubMed
79.
Vasikaran S, Cooper C, Eastell R, Griesmacher A, Morris HA, Trenti T, et al. International osteoporosis foundation and international federation of clinical chemistry and laboratory medicine position on bone marker standards in osteoporosis. Clin Chem Lab Med. 2011;49(8):1271–4.CrossRefPubMed
80.
Pérez-López F. Vitamin D and adolescent health. Adolescent Health, Medicine and Therapeutics. 2010;1:1–8.CrossRef
81.
Leger LA, Mercier D, Gadoury C, Lambert J. The multistage 20 metre shuttle run test for aerobic fitness. J Sports Sci. 1988;6(2):93–101.CrossRefPubMed
82.
Castro-Pinero J, Artero EG, Espana-Romero V, Ortega FB, Sjostrom M, Suni J, et al. Criterion-related validity of field-based fitness tests in youth: a systematic review. Br J Sports Med. 2010;44(13):934–43.CrossRefPubMed
83.
Ortega FB, Artero EG, Ruiz JR, Vicente-Rodriguez G, Bergman P, Hagstromer M, et al. Reliability of health-related physical fitness tests in European adolescents. The HELENA Study. Int J Obes (Lond). 2008;32 Suppl 5:S49–57.CrossRef
84.
Phillips LR, Parfitt G, Rowlands AV. Calibration of the GENEA accelerometer for assessment of physical activity intensity in children. J Sci Med Sport. 2013;16(2):124–8.CrossRefPubMed
85.
85. Helmerhorst HJF, Brage S, Warren J, Besson H, Ekelund U: A systematic review of reliability and objective criterion-related validity of physical activity questionnaires. Int J Behav Nutr Phy 2012, 9
86.
Slootmaker SM, Schuit AJ, Chinapaw MJ, Seidell JC, van Mechelen W. Disagreement in physical activity assessed by accelerometer and self-report in subgroups of age, gender, education and weight status. Int J Behav Nutr Phys Act. 2009;6:17.CrossRefPubMedPubMedCentral
87.
Gunter K, Baxter-Jones AD, Mirwald RL, Almstedt H, Fuller A, Durski S, et al. Jump starting skeletal health: a 4-year longitudinal study assessing the effects of jumping on skeletal development in pre and circum pubertal children. Bone. 2008;42(4):710–8.CrossRefPubMed
88.
Acero RM, Fernandez-del Olmo M, Sanchez JA, Otero XL, Aguado X, Rodriguez FA. Reliability of squat and countermovement jump tests in children 6 to 8 years of age. Pediatr Exerc Sci. 2011;23(1):151–60.CrossRefPubMed
89.
Markovic G, Dizdar D, Jukic I, Cardinale M. Reliability and factorial validity of squat and countermovement jump tests. J Strength Cond Res. 2004;18(3):551–5.PubMed
90.
McKay H, Tsang G, Heinonen A, MacKelvie K, Sanderson D, Khan KM. Ground reaction forces associated with an effective elementary school based jumping intervention. Br J Sports Med. 2005;39(1):10–4.CrossRefPubMedPubMedCentral
91.
Gracia-Marco L, Ortega FB, Jimenez Pavon D, Rodriguez G, Castillo MJ, Vicente Rodriguez G, et al. Adiposity and bone health in Spanish adolescents The HELENA. study Osteoporos Int. 2012;23(3):937–47.CrossRefPubMed
92.
Guadalupe-Grau A, Perez-Gomez J, Olmedillas H, Chavarren J, Dorado C, Santana A, et al. Strength training combined with plyometric jumps in adults: sex differences in fat-bone axis adaptations. J Appl Physiol. 2009;106(4):1100–11.CrossRefPubMed
93.
Hind K, Burrows M. Weight-bearing exercise and bone mineral accrual in children and adolescents: a review of controlled trials. Bone. 2007;40(1):14–27.CrossRefPubMed
94.
MacKelvie KJ, McKay HA, Petit MA, Moran O, Khan KM. Bone mineral response to a 7-month randomized controlled, school-based jumping intervention in 121 prepubertal boys: associations with ethnicity and body mass index. J Bone Miner Res. 2002;17(5):834–44.CrossRefPubMed
Metadata
Title
Effect of a program of short bouts of exercise on bone health in adolescents involved in different sports: the PRO-BONE study protocol
Authors
Dimitris Vlachopoulos
Alan R Barker
Craig A Williams
Karen M Knapp
Brad S Metcalf
Luis Gracia-Marco
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2015
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-015-1633-5

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