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Clinical Orthopaedics and Related Research®
Published in: Clinical Orthopaedics and Related Research® 9/2015

01-09-2015 | Editor's Spotlight/Take 5

Editor’s Spotlight/Take 5: A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis

Author: Seth S. Leopold, MD

Published in: Clinical Orthopaedics and Related Research® | Issue 9/2015

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Excerpt

It is astounding that in 2015, physicians cannot diagnose with certainty patients with a limb-threatening condition like bacterial osteomyelitis (or its evil twin, prosthetic joint infection). After all, we have been treating bone infections since the time of Hippocrates [5]. Surgeons sometimes fret about the lag time between diagnosis and treatment, but this is more than a lag—we have been waiting nearly 25 centuries to go from treatment to diagnosis. …
Literature
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Bingham J, Clarke H, Spangehl M, Schwarz A, Beauchamp C, Goldberg B. The alpha defensin-1 biomarker assay can be used to evaluate the potentially infected total joint arthroplasty. Clin Orthop Relat Res. 2014;472:4006–4009.PubMedCrossRef
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Byrne FM, Wilcox MH. MRSA prevention strategies and current guidelines. Injury. 2011;42 Suppl 5:S3–6.PubMedCrossRef
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Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J. Diagnosing periprosthetic joint infection: Has the era of the biomarker arrived? Clin Orthop Relat Res. 2014;472:3254–3262.PubMedCentralPubMedCrossRef
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Frangiamore SJ, Saleh A, Grosso MJ, Farias Kovac M, Higuera CA, Iannotti JP, Ricchetti ET. α-Defensin as a predictor of periprosthetic shoulder infection. [Published online ahead of print February 8, 2015]. J Shoulder Elbow Surg. DOI: 10.​1016/​j.​jse.​2014.​12.​021.
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McNeely TB, Shah NA, FridmanA, Joshi A, Hartzel JS, Keshari RS, Lupu F, DiNubile MJ. Mortality among recipients of the Merck V710 staphylococcus aureus vaccine after postoperative S. aureus infections: An analysis of possible contributing host factors. Hum Vaccin Immunother. 2014;10:3513–3516.
Metadata
Title
Editor’s Spotlight/Take 5: A Diagnostic Serum Antibody Test for Patients With Staphylococcus aureus Osteomyelitis
Author
Seth S. Leopold, MD
Publication date
01-09-2015
Publisher
Springer US
Published in
Clinical Orthopaedics and Related Research® / Issue 9/2015
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-015-4401-z

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