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Published in: Skeletal Radiology 1/2021

01-01-2021 | Edema | Scientific Article

Lateral femoral condyle insufficiency fractures: imaging findings, demographics, and analysis of outcomes

Authors: Terence P. Farrell, Diane M. Deely, Adam C. Zoga, Kristen E. McClure

Published in: Skeletal Radiology | Issue 1/2021

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Abstract

Objective

To describe imaging characteristics and demographics of lateral femoral condyle insufficiency fractures (LFCIFs) and identify characteristics associated with progression to epiphyseal collapse.

Materials and methods

A retrospective review of 105 consecutive patients with LFCIF was performed (mean age 58.1 years) after excluding post-traumatic and pathological fractures. Lesion size and location, presence of bone marrow edema–like signal, soft tissue edema, chondrosis grade, and meniscus pathology were documented. Demographics were recorded from the electronic patient record. Follow-up MRI and/or radiographs were evaluated for healing/stability or progression to epiphyseal collapse. Bone mineral density was assessed from dual-energy x-ray absorptiometry (DEXA) scans and/or radiographs.

Results

Fifty-six female and 49 male subjects were included. Female subjects were older at presentation (60.5 versus 56.3 years, p = .02). A total of 61.7% of the subjects with available DEXA and/or radiographs had osteopenia/osteoporosis. The central weight-bearing (61%) and outer condyle (54.3%) were most involved. High-grade chondrosis was present in ≥ 1 compartment in 70.5% including 42% in the lateral compartment. A total of 67.6% had ≥ 1 meniscus tear with similar frequency of medial and lateral tears (47.6% versus 41%). Bone marrow edema–like signal was present in all cases; soft tissue edema was present in 83.8%. Fifty-three subjects had available follow-up MRI (n = 24) and/or radiographs (n = 29). Increased age, fracture dimensions, presence of medial meniscus tears, and high-grade patellofemoral chondrosis were associated with progression (p ≤ .05).

Conclusion

LFCIFs are associated with meniscus tears, high-grade chondrosis, and osteopenia/osteoporosis with more global knee pathology present when compared with medial femoral condyle insufficiency fracture. Increased age, medial meniscus tears, fracture dimensions, and high-grade patellofemoral chondrosis were associated with progression.
Literature
1.
go back to reference Gorbachova T, Amber I, Beckmann NM, Bennett DL, Chang EY, Davis L, et al. Nomenclature of subchondral nonneoplastic bone lesions. Am J Roentgenol. 2019;213(5):963–82.CrossRef Gorbachova T, Amber I, Beckmann NM, Bennett DL, Chang EY, Davis L, et al. Nomenclature of subchondral nonneoplastic bone lesions. Am J Roentgenol. 2019;213(5):963–82.CrossRef
2.
go back to reference Lecouvet FE, van de Berg BC, Maldague BE, Lebon CJ, Jamart J, Saleh M, et al. Early irreversible osteonecrosis versus transient lesions of the femoral condyles: prognostic value of subchondral bone and marrow changes on MR imaging. AJR Am J Roentgenol. 1998;170(1):71–7.PubMedCrossRef Lecouvet FE, van de Berg BC, Maldague BE, Lebon CJ, Jamart J, Saleh M, et al. Early irreversible osteonecrosis versus transient lesions of the femoral condyles: prognostic value of subchondral bone and marrow changes on MR imaging. AJR Am J Roentgenol. 1998;170(1):71–7.PubMedCrossRef
3.
go back to reference Viana SL, Machado BB, Mendlovitz PS. MRI of subchondral fractures: a review. Skelet Radiol. 2014;43(11):1515–27.CrossRef Viana SL, Machado BB, Mendlovitz PS. MRI of subchondral fractures: a review. Skelet Radiol. 2014;43(11):1515–27.CrossRef
4.
go back to reference Gourlay ML, Renner JB, Spang JT, Rubin JE. Subchondral insufficiency fracture of the knee: a non-traumatic injury with prolonged recovery time. BMJ Case Rep. 2015;8:2015. Gourlay ML, Renner JB, Spang JT, Rubin JE. Subchondral insufficiency fracture of the knee: a non-traumatic injury with prolonged recovery time. BMJ Case Rep. 2015;8:2015.
5.
go back to reference Seeman E, Delmas PD. Bone quality--the material and structural basis of bone strength and fragility. N Engl J Med. 2006;354(21):2250–61.PubMedCrossRef Seeman E, Delmas PD. Bone quality--the material and structural basis of bone strength and fragility. N Engl J Med. 2006;354(21):2250–61.PubMedCrossRef
6.
go back to reference Pathria MN, Chung CB, Resnick DL. Acute and stress-related injuries of bone and cartilage: pertinent anatomy, basic biomechanics, and imaging perspective. Radiology. 2016;280(1):21–38.PubMedPubMedCentralCrossRef Pathria MN, Chung CB, Resnick DL. Acute and stress-related injuries of bone and cartilage: pertinent anatomy, basic biomechanics, and imaging perspective. Radiology. 2016;280(1):21–38.PubMedPubMedCentralCrossRef
7.
go back to reference Lee S, Saifuddin A. Magnetic resonance imaging of subchondral insufficiency fractures of the lower limb. Skelet Radiol. 2019;48(7):1011–21.CrossRef Lee S, Saifuddin A. Magnetic resonance imaging of subchondral insufficiency fractures of the lower limb. Skelet Radiol. 2019;48(7):1011–21.CrossRef
8.
go back to reference Daffner RH, Pavlov H. Stress fractures: current concepts. AJR Am J Roentgenol. 1992;159(2):245–52.PubMedCrossRef Daffner RH, Pavlov H. Stress fractures: current concepts. AJR Am J Roentgenol. 1992;159(2):245–52.PubMedCrossRef
10.
11.
go back to reference Karantanas AH, Drakonaki E, Karachalios T, Korompilias AV, Malizos K. Acute non-traumatic marrow edema syndrome in the knee: MRI findings at presentation, correlation with spinal DEXA and outcome. Eur J Radiol. 2008;67(1):22–33.PubMedCrossRef Karantanas AH, Drakonaki E, Karachalios T, Korompilias AV, Malizos K. Acute non-traumatic marrow edema syndrome in the knee: MRI findings at presentation, correlation with spinal DEXA and outcome. Eur J Radiol. 2008;67(1):22–33.PubMedCrossRef
13.
go back to reference Plett SK, Hackney LA, Heilmeier U, Nardo L, Yu A, Zhang CA, et al. Femoral condyle insufficiency fractures: associated clinical and morphological findings and impact on outcome. Skelet Radiol. 2015;44(12):1785–94.CrossRef Plett SK, Hackney LA, Heilmeier U, Nardo L, Yu A, Zhang CA, et al. Femoral condyle insufficiency fractures: associated clinical and morphological findings and impact on outcome. Skelet Radiol. 2015;44(12):1785–94.CrossRef
14.
go back to reference Wilmot AS, Ruutiainen AT, Bakhru PT, Schweitzer ME, Shabshin N. Subchondral insufficiency fracture of the knee: a recognizable associated soft tissue edema pattern and a similar distribution among men and women. Eur J Radiol. 2016;85(11):2096–103.PubMedCrossRef Wilmot AS, Ruutiainen AT, Bakhru PT, Schweitzer ME, Shabshin N. Subchondral insufficiency fracture of the knee: a recognizable associated soft tissue edema pattern and a similar distribution among men and women. Eur J Radiol. 2016;85(11):2096–103.PubMedCrossRef
15.
go back to reference Sayyid S, Younan Y, Sharma G, Singer A, Morrison W, Zoga A, et al. Subchondral insufficiency fracture of the knee: grading, risk factors, and outcome. Skelet Radiol. 2019;48(12):1961–74.CrossRef Sayyid S, Younan Y, Sharma G, Singer A, Morrison W, Zoga A, et al. Subchondral insufficiency fracture of the knee: grading, risk factors, and outcome. Skelet Radiol. 2019;48(12):1961–74.CrossRef
16.
go back to reference Muscolo DL, Costa-Paz M, Ayerza M, Makino A. Medial meniscal tears and spontaneous osteonecrosis of the knee. Arthroscopy. 2006;22(4):457–60.PubMedCrossRef Muscolo DL, Costa-Paz M, Ayerza M, Makino A. Medial meniscal tears and spontaneous osteonecrosis of the knee. Arthroscopy. 2006;22(4):457–60.PubMedCrossRef
17.
go back to reference Robertson DD, Armfield DR, Towers JD, Irrgang JJ, Maloney WJ, Harner CD. Meniscal root injury and spontaneous osteonecrosis of the knee: an observation. J Bone Joint Surg Br. 2009;91(2):190–5.PubMedCrossRef Robertson DD, Armfield DR, Towers JD, Irrgang JJ, Maloney WJ, Harner CD. Meniscal root injury and spontaneous osteonecrosis of the knee: an observation. J Bone Joint Surg Br. 2009;91(2):190–5.PubMedCrossRef
18.
go back to reference Yamamoto T, Bullough PG. Spontaneous osteonecrosis of the knee: the result of subchondral insufficiency fracture. J Bone Joint Surg Am. 2000;82(6):858–66.PubMedCrossRef Yamamoto T, Bullough PG. Spontaneous osteonecrosis of the knee: the result of subchondral insufficiency fracture. J Bone Joint Surg Am. 2000;82(6):858–66.PubMedCrossRef
19.
go back to reference Marti CB, Rodriguez M, Zanetti M, Romero J. Spontaneous osteonecrosis of the medial compartment of the knee: a MRI follow-up after conservative and operative treatment, preliminary results. Knee Surg Sports Traumatol Arthrosc. 2000;8(2):83–8.PubMedCrossRef Marti CB, Rodriguez M, Zanetti M, Romero J. Spontaneous osteonecrosis of the medial compartment of the knee: a MRI follow-up after conservative and operative treatment, preliminary results. Knee Surg Sports Traumatol Arthrosc. 2000;8(2):83–8.PubMedCrossRef
20.
go back to reference Carrino JA, Blum J, Parellada JA, Schweitzer ME, Morrison WB. MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts. Osteoarthr Cartil. 2006;14(10):1081–5.CrossRef Carrino JA, Blum J, Parellada JA, Schweitzer ME, Morrison WB. MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts. Osteoarthr Cartil. 2006;14(10):1081–5.CrossRef
21.
22.
go back to reference Gomoll AH, Minas T, Farr J, Cole BJ. Treatment of chondral defects in the patellofemoral joint. J Knee Surg. 2006;19(4):285–95.PubMedCrossRef Gomoll AH, Minas T, Farr J, Cole BJ. Treatment of chondral defects in the patellofemoral joint. J Knee Surg. 2006;19(4):285–95.PubMedCrossRef
23.
go back to reference Pelletier J-P, Raynauld J-P, Abram F, Haraoui B, Choquette D, Martel-Pelletier J. A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI. Osteoarthr Cartil. 2008;16(Suppl 3):S8–13.CrossRef Pelletier J-P, Raynauld J-P, Abram F, Haraoui B, Choquette D, Martel-Pelletier J. A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI. Osteoarthr Cartil. 2008;16(Suppl 3):S8–13.CrossRef
24.
go back to reference Nelson FR, Craig J, Francois H, Azuh O, Oyetakin-White P, King B. Subchondral insufficiency fractures and spontaneous osteonecrosis of the knee may not be related to osteoporosis. Arch Osteoporos. 2014;9:194.PubMedCrossRef Nelson FR, Craig J, Francois H, Azuh O, Oyetakin-White P, King B. Subchondral insufficiency fractures and spontaneous osteonecrosis of the knee may not be related to osteoporosis. Arch Osteoporos. 2014;9:194.PubMedCrossRef
25.
go back to reference Nakagawa S, Kadoya Y, Todo S, Kobayashi A, Sakamoto H, Freeman MA, et al. Tibiofemoral movement 3: full flexion in the living knee studied by MRI. J Bone Joint Surg Br. 2000;82(8):1199–200.PubMedCrossRef Nakagawa S, Kadoya Y, Todo S, Kobayashi A, Sakamoto H, Freeman MA, et al. Tibiofemoral movement 3: full flexion in the living knee studied by MRI. J Bone Joint Surg Br. 2000;82(8):1199–200.PubMedCrossRef
26.
go back to reference Depasquale R, Fotiadou A, Kumar DS, Lalam R, Tins B, Tyrrell PNM, et al. Subchondral impaction fractures of the non-weight-bearing portion of the lateral femoral condyle. Skelet Radiol. 2013;42(2):177–85.CrossRef Depasquale R, Fotiadou A, Kumar DS, Lalam R, Tins B, Tyrrell PNM, et al. Subchondral impaction fractures of the non-weight-bearing portion of the lateral femoral condyle. Skelet Radiol. 2013;42(2):177–85.CrossRef
27.
go back to reference Radin EL, Paul IL. Does cartilage compliance reduce skeletal impact loads? The relative force-attenuating properties of articular cartilage, synovial fluid, periarticular soft tissues and bone. Arthritis Rheum. 1970;13(2):139–44.PubMedCrossRef Radin EL, Paul IL. Does cartilage compliance reduce skeletal impact loads? The relative force-attenuating properties of articular cartilage, synovial fluid, periarticular soft tissues and bone. Arthritis Rheum. 1970;13(2):139–44.PubMedCrossRef
28.
go back to reference Radin EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res. 1986;213:34–40. Radin EL, Rose RM. Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res. 1986;213:34–40.
29.
go back to reference Madry H, van Dijk CN, Mueller-Gerbl M. The basic science of the subchondral bone. Knee Surg Sports Traumatol Arthrosc. 2010;18(4):419–33.PubMedCrossRef Madry H, van Dijk CN, Mueller-Gerbl M. The basic science of the subchondral bone. Knee Surg Sports Traumatol Arthrosc. 2010;18(4):419–33.PubMedCrossRef
30.
go back to reference Layton MW, Goldstein SA, Goulet RW, Feldkamp LA, Kubinski DJ, Bole GG. Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography. Arthritis Rheum. 1988;31(11):1400–5.PubMedCrossRef Layton MW, Goldstein SA, Goulet RW, Feldkamp LA, Kubinski DJ, Bole GG. Examination of subchondral bone architecture in experimental osteoarthritis by microscopic computed axial tomography. Arthritis Rheum. 1988;31(11):1400–5.PubMedCrossRef
31.
go back to reference Wright NC, Looker AC, Saag KG, Curtis JR, Delzell ES, Randall S, et al. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res. 2014;29(11):2520–6.PubMedPubMedCentralCrossRef Wright NC, Looker AC, Saag KG, Curtis JR, Delzell ES, Randall S, et al. The recent prevalence of osteoporosis and low bone mass in the United States based on bone mineral density at the femoral neck or lumbar spine. J Bone Miner Res. 2014;29(11):2520–6.PubMedPubMedCentralCrossRef
32.
go back to reference Yamamoto T, Iwamoto Y, Schneider R, Bullough PG. Histopathological prevalence of subchondral insufficiency fracture of the femoral head. Ann Rheum Dis. 2008;67(2):150–3.PubMedCrossRef Yamamoto T, Iwamoto Y, Schneider R, Bullough PG. Histopathological prevalence of subchondral insufficiency fracture of the femoral head. Ann Rheum Dis. 2008;67(2):150–3.PubMedCrossRef
33.
go back to reference Zanetti M, Romero J, Dambacher MA, Hodler J. Osteonecrosis diagnosed on MR images of the knee. Relationship to reduced bone mineral density determined by high resolution peripheral quantitative CT. Acta Radiol. 2003;44(5):525–31.PubMed Zanetti M, Romero J, Dambacher MA, Hodler J. Osteonecrosis diagnosed on MR images of the knee. Relationship to reduced bone mineral density determined by high resolution peripheral quantitative CT. Acta Radiol. 2003;44(5):525–31.PubMed
34.
go back to reference Lotke PA, Abend JA, Ecker ML. The treatment of osteonecrosis of the medial femoral condyle. Clin Orthop Relat Res. 1982;171:109–16. Lotke PA, Abend JA, Ecker ML. The treatment of osteonecrosis of the medial femoral condyle. Clin Orthop Relat Res. 1982;171:109–16.
35.
go back to reference Norman A, Baker ND. Spontaneous osteonecrosis of the knee and medial meniscal tears. Radiology. 1978;129(3):653–6.PubMedCrossRef Norman A, Baker ND. Spontaneous osteonecrosis of the knee and medial meniscal tears. Radiology. 1978;129(3):653–6.PubMedCrossRef
36.
go back to reference Pan J, Pialat J-B, Joseph T, Kuo D, Joseph GB, Nevitt MC, et al. Knee cartilage T2 characteristics and evolution in relation to morphologic abnormalities detected at 3-T MR imaging: a longitudinal study of the Normal control cohort from the osteoarthritis initiative. Radiology. 2011;261(2):507–15.PubMedPubMedCentralCrossRef Pan J, Pialat J-B, Joseph T, Kuo D, Joseph GB, Nevitt MC, et al. Knee cartilage T2 characteristics and evolution in relation to morphologic abnormalities detected at 3-T MR imaging: a longitudinal study of the Normal control cohort from the osteoarthritis initiative. Radiology. 2011;261(2):507–15.PubMedPubMedCentralCrossRef
Metadata
Title
Lateral femoral condyle insufficiency fractures: imaging findings, demographics, and analysis of outcomes
Authors
Terence P. Farrell
Diane M. Deely
Adam C. Zoga
Kristen E. McClure
Publication date
01-01-2021
Publisher
Springer Berlin Heidelberg
Published in
Skeletal Radiology / Issue 1/2021
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-020-03548-z

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