Skip to main content
Top
Published in: Archives of Osteoporosis 1/2014

01-12-2014 | Original Article

Subchondral insufficiency fractures and spontaneous osteonecrosis of the knee may not be related to osteoporosis

Authors: Fred R. Nelson, Joseph Craig, Howard Francois, Ogochukwu Azuh, Patricia Oyetakin-White, Brandon King

Published in: Archives of Osteoporosis | Issue 1/2014

Login to get access

Abstract

Summary

The term insufficiency fracture implies inadequate bone and is applied to some subchondral knee magnetic resonance images. We reviewed bone mineral density, body mass index, meniscal extrusion, comorbidities, and demographics in 32 knee insufficiency fracture patients. Only five were osteoporotic. Meniscal extrusion was predominant.

Purpose

The literature supports systemic osteoporosis as a risk fracture for spontaneous osteonecrosis of the knee (SONK). SONK is also called a subchondral insufficiency fracture. Recognizing that insufficiency fracture and SONK are related, we designed this retrospective study to determine if knee subchondral insufficiency fractures were associated with osteoporosis based on bone mineral density.

Methods

Based on magnetic resonance imaging findings, 32 patients were diagnosed as having an insufficiency fracture by an orthopaedic surgeon with magnetic resonance imaging confirmation by a musculoskeletal radiologist. We reviewed body mass index, age, sex, comorbidities, demographics, and bone mineral density using both T-scores and Z-scores.

Results

The average age was 70, and only five patients were osteoporotic. Twenty-six of the 32 patients were female. The average age-related Z-score was 1 standard deviation above normal.

Conclusions

We conclude that osteoporosis is not the underlying cause of this disorder in the majority of patients.
Literature
2.
go back to reference Oyen J, Gjesdal CG, Brudvik C, Hove LM, Apalset EM, Gulseth HC, Haugeberg G (2010) Low-energy distal radius fractures in middle-aged and elderly men and women—the burden of osteoporosis and fracture risk: a study of 1794 consecutive patients. Osteoporos Int 21:1257–1267PubMedCrossRef Oyen J, Gjesdal CG, Brudvik C, Hove LM, Apalset EM, Gulseth HC, Haugeberg G (2010) Low-energy distal radius fractures in middle-aged and elderly men and women—the burden of osteoporosis and fracture risk: a study of 1794 consecutive patients. Osteoporos Int 21:1257–1267PubMedCrossRef
3.
go back to reference Malluche HH, Porter DS, Mawad H, Monier-Faugere MC, Pienkowski D (2013) Low-energy fractures without low T-scores characteristic of osteoporosis: a possible bone matrix disorder. J Bone Joint Surg Am 95:e1391–1396PubMedCrossRef Malluche HH, Porter DS, Mawad H, Monier-Faugere MC, Pienkowski D (2013) Low-energy fractures without low T-scores characteristic of osteoporosis: a possible bone matrix disorder. J Bone Joint Surg Am 95:e1391–1396PubMedCrossRef
4.
go back to reference Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385–397PubMedCentralPubMedCrossRef Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E (2008) FRAX and the assessment of fracture probability in men and women from the UK. Osteoporos Int 19:385–397PubMedCentralPubMedCrossRef
5.
go back to reference Lingg GM, Soltesz I, Kessler S, Dreher R (1997) Insufficiency and stress fractures of the long bones occurring in patients with rheumatoid arthritis and other inflammatory diseases, with a contribution on the possibilities of computed tomography. Eur J Radiol 26:54–63PubMedCrossRef Lingg GM, Soltesz I, Kessler S, Dreher R (1997) Insufficiency and stress fractures of the long bones occurring in patients with rheumatoid arthritis and other inflammatory diseases, with a contribution on the possibilities of computed tomography. Eur J Radiol 26:54–63PubMedCrossRef
6.
go back to reference Lafforgue P, Daumen-Legre V, Clairet D, Daver L, Acquaviva PC (1996) Insufficiency fractures of the medial femoral condyle. Rev Rhum Engl Ed 63:262–269PubMed Lafforgue P, Daumen-Legre V, Clairet D, Daver L, Acquaviva PC (1996) Insufficiency fractures of the medial femoral condyle. Rev Rhum Engl Ed 63:262–269PubMed
7.
go back to reference Ahlbäck S (1968) Osteoarthritis of the knee: a radiographic investigation. Acta Radiol Diagn (Stockh) suppl 277:7–72 Ahlbäck S (1968) Osteoarthritis of the knee: a radiographic investigation. Acta Radiol Diagn (Stockh) suppl 277:7–72
8.
go back to reference Ahlbäck S, Bauer GC, Bohne WH (1968) Spontaneous osteonecrosis of the knee. Arthritis Rheum 11:705–733PubMedCrossRef Ahlbäck S, Bauer GC, Bohne WH (1968) Spontaneous osteonecrosis of the knee. Arthritis Rheum 11:705–733PubMedCrossRef
9.
go back to reference Ecker ML, Lotke PA (1994) Spontaneous osteonecrosis of the knee. J Am Acad Orthop Surg 2:173–178PubMed Ecker ML, Lotke PA (1994) Spontaneous osteonecrosis of the knee. J Am Acad Orthop Surg 2:173–178PubMed
10.
go back to reference Yamamoto T, Bullough PG (2000) Spontaneous osteonecrosis of the knee: the result of subchondral insufficiency fracture. J Bone Joint Surg Am 82:858–866PubMedCrossRef Yamamoto T, Bullough PG (2000) Spontaneous osteonecrosis of the knee: the result of subchondral insufficiency fracture. J Bone Joint Surg Am 82:858–866PubMedCrossRef
11.
go back to reference Kidwai AS, Hemphill SD, Griffiths HJ (2005) Radiologic case study. Spontaneous osteonecrosis of the knee reclassified as insufficiency fracture. Orthopedics 28(236):333–236 Kidwai AS, Hemphill SD, Griffiths HJ (2005) Radiologic case study. Spontaneous osteonecrosis of the knee reclassified as insufficiency fracture. Orthopedics 28(236):333–236
12.
go back to reference Cabarrus MC, Ambekar A, Lu Y, Link TM (2008) MRI and CT of insufficiency fractures of the pelvis and the proximal femur. AJR Am J Roentgenol 191:995–1001PubMedCrossRef Cabarrus MC, Ambekar A, Lu Y, Link TM (2008) MRI and CT of insufficiency fractures of the pelvis and the proximal femur. AJR Am J Roentgenol 191:995–1001PubMedCrossRef
13.
go back to reference Aratake M, Yoshifumi T, Takahashi A, Takeuchi R, Inoue T, Saito T (2009) Evaluation of lesion in a spontaneous osteonecrosis of the knee using 18F-fluoride positron emission tomography. Knee Surg Sports Traumatol Arthrosc 17:53–59PubMedCrossRef Aratake M, Yoshifumi T, Takahashi A, Takeuchi R, Inoue T, Saito T (2009) Evaluation of lesion in a spontaneous osteonecrosis of the knee using 18F-fluoride positron emission tomography. Knee Surg Sports Traumatol Arthrosc 17:53–59PubMedCrossRef
14.
go back to reference Scher C, Craig J, Nelson F (2008) Bone marrow edema in the knee in osteoarthrosis and association with total knee arthroplasty within a three-year follow-up. Skelet Radiol 37:609–617CrossRef Scher C, Craig J, Nelson F (2008) Bone marrow edema in the knee in osteoarthrosis and association with total knee arthroplasty within a three-year follow-up. Skelet Radiol 37:609–617CrossRef
15.
go back to reference Narvaez JA, Narvaez J, De Lama E, Sanchez A (2003) Spontaneous osteonecrosis of the knee associated with tibial plateau and femoral condyle insufficiency stress fracture. Eur Radiol 13:1843–1848PubMedCrossRef Narvaez JA, Narvaez J, De Lama E, Sanchez A (2003) Spontaneous osteonecrosis of the knee associated with tibial plateau and femoral condyle insufficiency stress fracture. Eur Radiol 13:1843–1848PubMedCrossRef
16.
go back to reference Zanetti M, Romero J, Dambacher MA, Hodler J (2003) Osteonecrosis diagnosed on MR images of the knee. Relationship to reduced bone mineral density determined by high resolution peripheral quantitative CT. Acta Radiol 44:525–531PubMed Zanetti M, Romero J, Dambacher MA, Hodler J (2003) Osteonecrosis diagnosed on MR images of the knee. Relationship to reduced bone mineral density determined by high resolution peripheral quantitative CT. Acta Radiol 44:525–531PubMed
17.
go back to reference Flynn MJ. Ksar JS. Blechinger JC. McGee RM (2007) Spatial response of x-ray tomosynthesis in relation to computed tomography. Paper presented at the Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, Chicago, IL, November 25–30, 2007 Flynn MJ. Ksar JS. Blechinger JC. McGee RM (2007) Spatial response of x-ray tomosynthesis in relation to computed tomography. Paper presented at the Radiological Society of North America 2007 Scientific Assembly and Annual Meeting, Chicago, IL, November 25–30, 2007
18.
go back to reference Flynn M. McGee R. Blechinger J (2007) Spatial resolution of x-ray tomosynthesis in relation to computed tomography for coronal images of the knee. Medical Imaging 2007: Physics of Medical Imaging; 18–22 February 2007; San Diego, CA. SPIE, Bellingham, WA Flynn M. McGee R. Blechinger J (2007) Spatial resolution of x-ray tomosynthesis in relation to computed tomography for coronal images of the knee. Medical Imaging 2007: Physics of Medical Imaging; 18–22 February 2007; San Diego, CA. SPIE, Bellingham, WA
19.
go back to reference National Institutes of Health (2000) Osteoporosis prevention, diagnosis, and therapy, vol 17. NIH Consens Statement, vol 1 National Institutes of Health (2000) Osteoporosis prevention, diagnosis, and therapy, vol 17. NIH Consens Statement, vol 1
20.
go back to reference Noyes FR, Stabler CL (1989) A system for grading articular cartilage lesions at arthroscopy. Amer J Sports Med 17:505–513CrossRef Noyes FR, Stabler CL (1989) A system for grading articular cartilage lesions at arthroscopy. Amer J Sports Med 17:505–513CrossRef
21.
go back to reference Satku K, Kumar VP, Chong SM, Thambyah A (2003) The natural history of spontaneous osteonecrosis of the medial tibial plateau. J Bone Joint Surg (Br) 85:983–988CrossRef Satku K, Kumar VP, Chong SM, Thambyah A (2003) The natural history of spontaneous osteonecrosis of the medial tibial plateau. J Bone Joint Surg (Br) 85:983–988CrossRef
22.
go back to reference Ramnath RR, Kattapuram SV (2004) MR appearance of SONK-like subchondral abnormalities in the adult knee: SONK redefined. Skelet Radiol 33:575–581CrossRef Ramnath RR, Kattapuram SV (2004) MR appearance of SONK-like subchondral abnormalities in the adult knee: SONK redefined. Skelet Radiol 33:575–581CrossRef
23.
go back to reference Ostlere SJ, Seeger LL, Eckardt JJ (1990) Subchondral cysts of the tibia secondary to osteoarthritis of the knee. Skelet Radiol 19:287–289CrossRef Ostlere SJ, Seeger LL, Eckardt JJ (1990) Subchondral cysts of the tibia secondary to osteoarthritis of the knee. Skelet Radiol 19:287–289CrossRef
24.
go back to reference MacDessi SJ, Brophy RH, Bullough PG, Windsor RE, Sculco TP (2008) Subchondral fracture following arthroscopic knee surgery a series of eight cases. J Bone Joint Surg Am 90:1007–1012PubMedCrossRef MacDessi SJ, Brophy RH, Bullough PG, Windsor RE, Sculco TP (2008) Subchondral fracture following arthroscopic knee surgery a series of eight cases. J Bone Joint Surg Am 90:1007–1012PubMedCrossRef
25.
go back to reference Narvaez J, Narvaez JA, Rodriguez-Moreno J, Roig-Escofet D (2000) Osteonecrosis of the knee: differences among idiopathic and secondary types. Rheumatology (Oxford) 39:982–989CrossRef Narvaez J, Narvaez JA, Rodriguez-Moreno J, Roig-Escofet D (2000) Osteonecrosis of the knee: differences among idiopathic and secondary types. Rheumatology (Oxford) 39:982–989CrossRef
26.
go back to reference Naot D, Cornish J (2014) Cytokines and hormones that contribute to the positive association between fat and bone. Front Endocrinol (Lausanne) 5:70 Naot D, Cornish J (2014) Cytokines and hormones that contribute to the positive association between fat and bone. Front Endocrinol (Lausanne) 5:70
27.
go back to reference Garino JP, Steinberg ME (1994) Etiology, diagnosis, and treatment of avascular necrosis of the femoral head. Curr Opin Orthop 5:3–10CrossRef Garino JP, Steinberg ME (1994) Etiology, diagnosis, and treatment of avascular necrosis of the femoral head. Curr Opin Orthop 5:3–10CrossRef
Metadata
Title
Subchondral insufficiency fractures and spontaneous osteonecrosis of the knee may not be related to osteoporosis
Authors
Fred R. Nelson
Joseph Craig
Howard Francois
Ogochukwu Azuh
Patricia Oyetakin-White
Brandon King
Publication date
01-12-2014
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2014
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-014-0194-z

Other articles of this Issue 1/2014

Archives of Osteoporosis 1/2014 Go to the issue