Published in:
01-04-2020 | Echocardiography | Original Article
Comprehensive Functional Echocardiographic Assessment of Transposition of the Great Arteries: From Fetus to Newborn
Authors:
Carin Walter, Iris Soveral, Joaquim Bartrons, María Clara Escobar, Juan Manuel Carretero, Laura Quirado, Olga Gómez, Joan Sánchez-de-Toledo
Published in:
Pediatric Cardiology
|
Issue 4/2020
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Abstract
To improve the understanding of the pathophysiology of transposition of the great arteries with intact ventricular septum (TGA/IVS) and the cardiac remodeling occurring from fetal to neonatal life, we performed a morphometric and functional echocardiographic assessment in fetuses and newborns. This was a prospective case–control study performed in a tertiary referral center, which included fetuses and newborns with a diagnosis of TGA/IVS between 2011 and 2018. Morphometry and systolic and diastolic function parameters were compared with age and body surface-matched healthy controls. Twenty-one TGA/IVS patients were included during the study period and morphometric and functional echocardiographic data were recorded. TGA/IVS patients showed morphometric and functional changes of increased overall volume and output, predominantly in the aortic component from fetus to newborn, probably due to compensatory mechanisms secondary to brain hypoxia.