Skip to main content
Top
Published in: BMC Geriatrics 1/2017

Open Access 01-12-2017 | Research Article

Eccentric versus traditional resistance exercise for older adult fallers in the community: a randomized trial within a multi-component fall reduction program

Authors: Paul LaStayo, Robin Marcus, Leland Dibble, Bob Wong, Ginette Pepper

Published in: BMC Geriatrics | Issue 1/2017

Login to get access

Abstract

Background

Addressing muscle deficits within a multi-component exercise fall reduction program is a priority, especially for the highest risk older adults, i.e., those who have fallen previously. Eccentric resistance exercise with its high-force producing potential, at a low energetic cost, may be ideally-suited to address muscle impairments in this population. The purpose of this study was to compare the effects of resistance exercise via negative, eccentrically-induced, work (RENEW) versus traditional (TRAD) resistance exercise on mobility, balance confidence, muscle power and cross sectional area, as well as the number of days high fall risk older adults survived without a fall event over a 1 year period.

Methods

Randomized, two group, four time point (over 1 year) clinical trial testing RENEW versus TRAD as part of a 3 month multi-component exercise fall reduction program (MCEFRP). Primary outcomes of mobility, balance confidence, muscle power output and cross sectional area were analyzed using mixed effects modeling. The secondary outcomes of days to fall and days to near-fall were analyzed using survival analysis.

Results

The MCEFRP did have an effect on fall risk factors considered reversible with exercise interventions though there was no differential effect of RENEW versus TRAD (p = 0.896) on mobility, balance confidence, muscle power and cross sectional area. There were also no group differences in the number of days survived without a fall (p = 0.565) or near-fall (p = 0.678). Despite 100% of participants having at least one fall in the year prior to the MCEFRP, however, after 3 months of exercise and 9 months of follow-up <50% had experienced a fall or near fall.

Conclusions

There were no differential effects of RENEW or TRAD as components of a MCEFRP on the primary or secondary outcomes. The two modes of resistance exercise had identical effects on fall risk and fall-free survival.

Trial registration

NCT01080196; March 2, 2010 (retrospectively registered).
Literature
1.
go back to reference Peeters G, van Schoor NM, Lips P. Fall risk: the clinical relevance of falls and how to integrate fall risk with fracture risk. Best Pract Res Clin Rheumatol. 2009;23(6):797–804.CrossRefPubMed Peeters G, van Schoor NM, Lips P. Fall risk: the clinical relevance of falls and how to integrate fall risk with fracture risk. Best Pract Res Clin Rheumatol. 2009;23(6):797–804.CrossRefPubMed
2.
go back to reference Rubenstein LZ, Josephson KR. Falls and their prevention in elderly people: what does the evidence show? Med Clin North Am. 2006;90(5):807–24.CrossRefPubMed Rubenstein LZ, Josephson KR. Falls and their prevention in elderly people: what does the evidence show? Med Clin North Am. 2006;90(5):807–24.CrossRefPubMed
3.
go back to reference Nevitt MC, et al. Risk factors for recurrent nonsyncopal falls. A prospective study. JAMA. 1989;261(18):2663–8.CrossRefPubMed Nevitt MC, et al. Risk factors for recurrent nonsyncopal falls. A prospective study. JAMA. 1989;261(18):2663–8.CrossRefPubMed
4.
go back to reference Teno J, Kiel DP, Mor V. Multiple stumbles: a risk factor for falls in community-dwelling elderly. A prospective study. J Am Geriatr Soc. 1990;38(12):1321–5.CrossRefPubMed Teno J, Kiel DP, Mor V. Multiple stumbles: a risk factor for falls in community-dwelling elderly. A prospective study. J Am Geriatr Soc. 1990;38(12):1321–5.CrossRefPubMed
5.
go back to reference Benichou O, Lord SR. Rationale for Strengthening Muscle to Prevent Falls and Fractures: A Review of the Evidence. Calcif Tissue Int. 2016;98(6):531–45.CrossRefPubMed Benichou O, Lord SR. Rationale for Strengthening Muscle to Prevent Falls and Fractures: A Review of the Evidence. Calcif Tissue Int. 2016;98(6):531–45.CrossRefPubMed
6.
go back to reference Moreland JD, et al. Muscle weakness and falls in older adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2004;52(7):1121–9.CrossRefPubMed Moreland JD, et al. Muscle weakness and falls in older adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2004;52(7):1121–9.CrossRefPubMed
7.
go back to reference Rubenstein LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing. 2006;35(Suppl 2):ii37–41.PubMed Rubenstein LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing. 2006;35(Suppl 2):ii37–41.PubMed
8.
go back to reference Bean JF, et al. A comparison of leg power and leg strength within the InCHIANTI study: which influences mobility more? J Gerontol A Biol Sci Med Sci. 2003;58(8):728–33.CrossRefPubMed Bean JF, et al. A comparison of leg power and leg strength within the InCHIANTI study: which influences mobility more? J Gerontol A Biol Sci Med Sci. 2003;58(8):728–33.CrossRefPubMed
9.
12.
go back to reference Avin KG, et al. Management of falls in community-dwelling older adults: clinical guidance statement from the Academy of Geriatric Physical Therapy of the American Physical Therapy Association. Phys Ther. 2015;95(6):815–34.CrossRefPubMedPubMedCentral Avin KG, et al. Management of falls in community-dwelling older adults: clinical guidance statement from the Academy of Geriatric Physical Therapy of the American Physical Therapy Association. Phys Ther. 2015;95(6):815–34.CrossRefPubMedPubMedCentral
14.
go back to reference LaStayo P, et al. Eccentric exercise in rehabilitation: safety, feasibility, and application. J Appl Physiol (1985). 2014;116(11):1426–34.CrossRef LaStayo P, et al. Eccentric exercise in rehabilitation: safety, feasibility, and application. J Appl Physiol (1985). 2014;116(11):1426–34.CrossRef
15.
go back to reference LaStayo PC, et al. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003;58(5):M419–24.CrossRefPubMed LaStayo PC, et al. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003;58(5):M419–24.CrossRefPubMed
16.
go back to reference Dibble LE, et al. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease. Mov Disord. 2006;21(9):1444–52.CrossRefPubMed Dibble LE, et al. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease. Mov Disord. 2006;21(9):1444–52.CrossRefPubMed
18.
19.
go back to reference LaStayo PC, et al. Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility--an exploratory pilot study. BMC Geriatr. 2011;11:5.CrossRefPubMedPubMedCentral LaStayo PC, et al. Eccentric exercise versus usual-care with older cancer survivors: the impact on muscle and mobility--an exploratory pilot study. BMC Geriatr. 2011;11:5.CrossRefPubMedPubMedCentral
20.
go back to reference Roig M, et al. The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis. Br J Sports Med. 2009;43(8):556–68.CrossRefPubMed Roig M, et al. The effects of eccentric versus concentric resistance training on muscle strength and mass in healthy adults: a systematic review with meta-analysis. Br J Sports Med. 2009;43(8):556–68.CrossRefPubMed
21.
go back to reference Gillespie LD, et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2012;9:CD007146. Gillespie LD, et al. Interventions for preventing falls in older people living in the community. Cochrane Database Syst Rev. 2012;9:CD007146.
22.
go back to reference Franco MR, Pereira LS, Ferreira PH. Exercise interventions for preventing falls in older people living in the community. Br J Sports Med. 2014;48(10):867–8.CrossRefPubMed Franco MR, Pereira LS, Ferreira PH. Exercise interventions for preventing falls in older people living in the community. Br J Sports Med. 2014;48(10):867–8.CrossRefPubMed
24.
go back to reference Borson S, et al. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc. 2003;51(10):1451–4.CrossRefPubMed Borson S, et al. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc. 2003;51(10):1451–4.CrossRefPubMed
26.
go back to reference Halvarsson A, et al. Effects of new, individually adjusted, progressive balance group training for elderly people with fear of falling and tend to fall: a randomized controlled trial. Clin Rehabil. 2011;25(11):1021–31.CrossRefPubMed Halvarsson A, et al. Effects of new, individually adjusted, progressive balance group training for elderly people with fear of falling and tend to fall: a randomized controlled trial. Clin Rehabil. 2011;25(11):1021–31.CrossRefPubMed
27.
go back to reference Beling J, Roller M. Multifactorial intervention with balance training as a core component among fall-prone older adults. J Geriatr Phys Ther. 2009;32(3):125–33.CrossRefPubMed Beling J, Roller M. Multifactorial intervention with balance training as a core component among fall-prone older adults. J Geriatr Phys Ther. 2009;32(3):125–33.CrossRefPubMed
28.
go back to reference Nelson ME, et al. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial. JAMA. 1994;272(24):1909–14.CrossRefPubMed Nelson ME, et al. Effects of high-intensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial. JAMA. 1994;272(24):1909–14.CrossRefPubMed
29.
go back to reference Noble BJ, et al. A category-ratio perceived exertion scale: relationship to blood and muscle lactates and heart rate. Med Sci Sports Exerc. 1983;15(6):523–8.CrossRefPubMed Noble BJ, et al. A category-ratio perceived exertion scale: relationship to blood and muscle lactates and heart rate. Med Sci Sports Exerc. 1983;15(6):523–8.CrossRefPubMed
30.
go back to reference Enright PL, et al. The 6-min walk test: a quick measure of functional status in elderly adults. Chest. 2003;123(2):387–98.CrossRefPubMed Enright PL, et al. The 6-min walk test: a quick measure of functional status in elderly adults. Chest. 2003;123(2):387–98.CrossRefPubMed
31.
go back to reference Steffen TM, Hacker TA, Mollinger L. Age- and gender-related test performance in community-dwelling elderly people: six-minute walk test, berg balance scale, timed up & go test, and gait speeds. Phys Ther. 2002;82(2):128–37.CrossRefPubMed Steffen TM, Hacker TA, Mollinger L. Age- and gender-related test performance in community-dwelling elderly people: six-minute walk test, berg balance scale, timed up & go test, and gait speeds. Phys Ther. 2002;82(2):128–37.CrossRefPubMed
32.
go back to reference Powell LE, Myers AM. The activities-specific balance confidence (ABC) scale. J Gerontol A Biol Sci Med Sci. 1995;50A(1):M28–34.CrossRefPubMed Powell LE, Myers AM. The activities-specific balance confidence (ABC) scale. J Gerontol A Biol Sci Med Sci. 1995;50A(1):M28–34.CrossRefPubMed
33.
go back to reference Myers AM, et al. Psychological indicators of balance confidence: relationship to actual and perceived abilities. J Gerontol A Biol Sci Med Sci. 1996;51(1):M37–43.CrossRefPubMed Myers AM, et al. Psychological indicators of balance confidence: relationship to actual and perceived abilities. J Gerontol A Biol Sci Med Sci. 1996;51(1):M37–43.CrossRefPubMed
34.
go back to reference Bassey EJ, Short AH. A new method for measuring power output in a single leg extension: feasibility, reliability and validity. Eur J Appl Physiol Occup Physiol. 1990;60(5):385–90.CrossRefPubMed Bassey EJ, Short AH. A new method for measuring power output in a single leg extension: feasibility, reliability and validity. Eur J Appl Physiol Occup Physiol. 1990;60(5):385–90.CrossRefPubMed
36.
go back to reference Wolf SL, et al. Selected as the best paper in the 1990s: reducing frailty and falls in older persons: an investigation of tai chi and computerized balance training. J Am Geriatr Soc. 2003;51(12):1794–803.CrossRefPubMed Wolf SL, et al. Selected as the best paper in the 1990s: reducing frailty and falls in older persons: an investigation of tai chi and computerized balance training. J Am Geriatr Soc. 2003;51(12):1794–803.CrossRefPubMed
37.
go back to reference Connell BR, Wolf SL. Environmental and behavioral circumstances associated with falls at home among healthy elderly individuals. Atlanta FICSIT Group. Arch Phys Med Rehabil. 1997;78(2):179–86.CrossRefPubMed Connell BR, Wolf SL. Environmental and behavioral circumstances associated with falls at home among healthy elderly individuals. Atlanta FICSIT Group. Arch Phys Med Rehabil. 1997;78(2):179–86.CrossRefPubMed
38.
go back to reference Hauer K, et al. Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials. Age Ageing. 2006;35(1):5–10.CrossRefPubMed Hauer K, et al. Systematic review of definitions and methods of measuring falls in randomised controlled fall prevention trials. Age Ageing. 2006;35(1):5–10.CrossRefPubMed
39.
go back to reference Hortobagyi T, Money J, Zheng D, et al. Muscle adaptations to 7 days of exercise in young and older humans: Eccentric overload versus standard resistance training. J Aging Phys Act. 2002;10:290–305.CrossRef Hortobagyi T, Money J, Zheng D, et al. Muscle adaptations to 7 days of exercise in young and older humans: Eccentric overload versus standard resistance training. J Aging Phys Act. 2002;10:290–305.CrossRef
40.
go back to reference Mueller M, et al. Different response to eccentric and concentric training in older men and women. Eur J Appl Physiol. 2009;107(2):145–53.CrossRefPubMed Mueller M, et al. Different response to eccentric and concentric training in older men and women. Eur J Appl Physiol. 2009;107(2):145–53.CrossRefPubMed
41.
go back to reference Lindstedt SL, et al. Do muscles function as adaptable locomotor springs? J Exp Biol. 2002;205(Pt 15):2211–6.PubMed Lindstedt SL, et al. Do muscles function as adaptable locomotor springs? J Exp Biol. 2002;205(Pt 15):2211–6.PubMed
42.
go back to reference Rassier DE, Herzog W. Force enhancement following an active stretch in skeletal muscle. J Electromyogr Kinesiol. 2002;12(6):471–7.CrossRefPubMed Rassier DE, Herzog W. Force enhancement following an active stretch in skeletal muscle. J Electromyogr Kinesiol. 2002;12(6):471–7.CrossRefPubMed
43.
go back to reference Lindstedt SL, LaStayo PC, Reich TE. When active muscles lengthen: properties and consequences of eccentric contractions. News Physiol Sci. 2001;16:256–61.PubMed Lindstedt SL, LaStayo PC, Reich TE. When active muscles lengthen: properties and consequences of eccentric contractions. News Physiol Sci. 2001;16:256–61.PubMed
45.
go back to reference Nagano H, et al. Contribution of lower limb eccentric work and different step responses to balance recovery among older adults. Gait Posture. 2015;42(3):257–62.CrossRefPubMed Nagano H, et al. Contribution of lower limb eccentric work and different step responses to balance recovery among older adults. Gait Posture. 2015;42(3):257–62.CrossRefPubMed
46.
go back to reference Chung-Hoon K, et al. The association between knee extensor force steadiness, force accuracy, and mobility in older adults who have fallen. J Geriatr Phys Ther. 2016;39(1):1–7.CrossRefPubMedPubMedCentral Chung-Hoon K, et al. The association between knee extensor force steadiness, force accuracy, and mobility in older adults who have fallen. J Geriatr Phys Ther. 2016;39(1):1–7.CrossRefPubMedPubMedCentral
47.
go back to reference Tanimoto Y, et al. Sarcopenia and falls in community-dwelling elderly subjects in Japan: Defining sarcopenia according to criteria of the European Working Group on Sarcopenia in Older People. Arch Gerontol Geriatr. 2014;59(2):295–9.CrossRefPubMed Tanimoto Y, et al. Sarcopenia and falls in community-dwelling elderly subjects in Japan: Defining sarcopenia according to criteria of the European Working Group on Sarcopenia in Older People. Arch Gerontol Geriatr. 2014;59(2):295–9.CrossRefPubMed
48.
go back to reference Landi F, et al. Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. Clin Nutr. 2012;31(5):652–8.CrossRefPubMed Landi F, et al. Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. Clin Nutr. 2012;31(5):652–8.CrossRefPubMed
49.
go back to reference Clynes MA, et al. Definitions of Sarcopenia: associations with previous falls and fracture in a population sample. Calcif Tissue Int. 2015;97(5):445–52.CrossRefPubMedPubMedCentral Clynes MA, et al. Definitions of Sarcopenia: associations with previous falls and fracture in a population sample. Calcif Tissue Int. 2015;97(5):445–52.CrossRefPubMedPubMedCentral
50.
go back to reference Raj IS, et al. Effects of eccentrically biased versus conventional weight training in older adults. Med Sci Sports Exerc. 2012;44(6):1167–76.CrossRefPubMed Raj IS, et al. Effects of eccentrically biased versus conventional weight training in older adults. Med Sci Sports Exerc. 2012;44(6):1167–76.CrossRefPubMed
51.
go back to reference Dias CP, et al. Effects of eccentric-focused and conventional resistance training on strength and functional capacity of older adults. Age (Dordr). 2015;37(5):99.CrossRef Dias CP, et al. Effects of eccentric-focused and conventional resistance training on strength and functional capacity of older adults. Age (Dordr). 2015;37(5):99.CrossRef
52.
go back to reference Dibble LE, et al. Exercise and medication effects on persons with Parkinson disease across the domains of disability: a randomized clinical trial. J Neurol Phys Ther. 2015;39(2):85–92.CrossRefPubMedPubMedCentral Dibble LE, et al. Exercise and medication effects on persons with Parkinson disease across the domains of disability: a randomized clinical trial. J Neurol Phys Ther. 2015;39(2):85–92.CrossRefPubMedPubMedCentral
53.
go back to reference Sherrington C, et al. Exercise to prevent falls in older adults: an updated meta-analysis and best practice recommendations. N S W Public Health Bull. 2011;22(3–4):78–83.CrossRefPubMed Sherrington C, et al. Exercise to prevent falls in older adults: an updated meta-analysis and best practice recommendations. N S W Public Health Bull. 2011;22(3–4):78–83.CrossRefPubMed
54.
go back to reference Davis JC, et al. Economic evaluation of dose-response resistance training in older women: a cost-effectiveness and cost-utility analysis. Osteoporos Int. 2011;22(5):1355–66.CrossRefPubMed Davis JC, et al. Economic evaluation of dose-response resistance training in older women: a cost-effectiveness and cost-utility analysis. Osteoporos Int. 2011;22(5):1355–66.CrossRefPubMed
55.
go back to reference Fiatarone MA, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med. 1994;330(25):1769–75.CrossRefPubMed Fiatarone MA, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med. 1994;330(25):1769–75.CrossRefPubMed
56.
go back to reference Woo J, et al. A randomised controlled trial of Tai Chi and resistance exercise on bone health, muscle strength and balance in community-living elderly people. Age Ageing. 2007;36(3):262–8.CrossRefPubMed Woo J, et al. A randomised controlled trial of Tai Chi and resistance exercise on bone health, muscle strength and balance in community-living elderly people. Age Ageing. 2007;36(3):262–8.CrossRefPubMed
57.
go back to reference Latham NK, et al. A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS). J Am Geriatr Soc. 2003;51(3):291–9.CrossRefPubMed Latham NK, et al. A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS). J Am Geriatr Soc. 2003;51(3):291–9.CrossRefPubMed
58.
go back to reference Province MA, et al. The effects of exercise on falls in elderly patients. A preplanned meta-analysis of the FICSIT Trials. Frailty and injuries: cooperative studies of intervention techniques. JAMA. 1995;273(17):1341–7.CrossRefPubMed Province MA, et al. The effects of exercise on falls in elderly patients. A preplanned meta-analysis of the FICSIT Trials. Frailty and injuries: cooperative studies of intervention techniques. JAMA. 1995;273(17):1341–7.CrossRefPubMed
59.
go back to reference Serra-Rexach JA, et al. Short-term, light- to moderate-intensity exercise training improves leg muscle strength in the oldest old: a randomized controlled trial. J Am Geriatr Soc. 2011;59(4):594–602.CrossRefPubMed Serra-Rexach JA, et al. Short-term, light- to moderate-intensity exercise training improves leg muscle strength in the oldest old: a randomized controlled trial. J Am Geriatr Soc. 2011;59(4):594–602.CrossRefPubMed
60.
go back to reference Donald IP, et al. Preventing falls on an elderly care rehabilitation ward. Clin Rehabil. 2000;14(2):178–85.CrossRefPubMed Donald IP, et al. Preventing falls on an elderly care rehabilitation ward. Clin Rehabil. 2000;14(2):178–85.CrossRefPubMed
61.
go back to reference Liu-Ambrose T, et al. Resistance and agility training reduce fall risk in women aged 75 to 85 with low bone mass: a 6-month randomized, controlled trial. J Am Geriatr Soc. 2004;52(5):657–65.CrossRefPubMedPubMedCentral Liu-Ambrose T, et al. Resistance and agility training reduce fall risk in women aged 75 to 85 with low bone mass: a 6-month randomized, controlled trial. J Am Geriatr Soc. 2004;52(5):657–65.CrossRefPubMedPubMedCentral
62.
go back to reference Ryan JW, Dinkel JL, Petrucci K. Near falls incidence. A study of older adults in the community. J Gerontol Nurs. 1993;19(12):23–8.CrossRefPubMed Ryan JW, Dinkel JL, Petrucci K. Near falls incidence. A study of older adults in the community. J Gerontol Nurs. 1993;19(12):23–8.CrossRefPubMed
Metadata
Title
Eccentric versus traditional resistance exercise for older adult fallers in the community: a randomized trial within a multi-component fall reduction program
Authors
Paul LaStayo
Robin Marcus
Leland Dibble
Bob Wong
Ginette Pepper
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Geriatrics / Issue 1/2017
Electronic ISSN: 1471-2318
DOI
https://doi.org/10.1186/s12877-017-0539-8

Other articles of this Issue 1/2017

BMC Geriatrics 1/2017 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.