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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2010

Open Access 01-12-2010 | Review

Eag and HERG potassium channels as novel therapeutic targets in cancer

Authors: Viren Asher, Heidi Sowter, Robert Shaw, Anish Bali, Raheela Khan

Published in: World Journal of Surgical Oncology | Issue 1/2010

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Abstract

Voltage gated potassium channels have been extensively studied in relation to cancer. In this review, we will focus on the role of two potassium channels, Ether à-go-go (Eag), Human ether à-go-go related gene (HERG), in cancer and their potential therapeutic utility in the treatment of cancer. Eag and HERG are expressed in cancers of various organs and have been implicated in cell cycle progression and proliferation of cancer cells. Inhibition of these channels has been shown to reduce proliferation both in vitro and vivo studies identifying potassium channel modulators as putative inhibitors of tumour progression. Eag channels in view of their restricted expression in normal tissue may emerge as novel tumour biomarkers.
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Metadata
Title
Eag and HERG potassium channels as novel therapeutic targets in cancer
Authors
Viren Asher
Heidi Sowter
Robert Shaw
Anish Bali
Raheela Khan
Publication date
01-12-2010
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2010
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/1477-7819-8-113

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