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Published in: International Journal of Colorectal Disease 2/2016

01-02-2016 | Original Article

E-PASS score as a useful predictor of postoperative complications and mortality after colorectal surgery in elderly patients

Authors: Tetsuro Tominaga, Hiroaki Takeshita, Katsunori Takagi, Masaki Kunizaki, Kazuo To, Takafumi Abo, Shigekazu Hidaka, Atsushi Nanashima, Takeshi Nagayasu, Terumitsu Sawai

Published in: International Journal of Colorectal Disease | Issue 2/2016

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Abstract

Purpose

The aim of this study was to clarify whether a surgical-specific risk scoring system estimating the physiologic ability and surgical stress (E-PASS) score was useful for prediction of postoperative morbidity and mortality.

Methods

The E-PASS score consists of the preoperative risk score (PRS), surgical stress score (SSS), and the comprehensive risk score (CRS). Conventional scoring systems [colorectal physiologic and operative severity score for the enumeration of mortality (CR-POSSUM) and the prognostic nutritional index (PNI)] were also examined. We retrospectively compared these scores in patients with or without postoperative complications. We assessed the relationship between these scores, clinicopathological features and postoperative mortality.

Results

Postoperative complications developed in 78 patients (33 %). American Society of Anesthesiologists score, performance status, PNI score, PRS, SSS, and CRS were significantly higher in patients with postoperative complications than in those without postoperative complications (p < 0.05). The area under the receiver operating characteristic curve (AUC) was highest for E-PASS [E-PASS (PRS, 0.74; SSS, 0.62; CRS, 0.78), PNI (0.62), CR-POSSUM (PS, 0.57; OSS, 0.52)]. Multivariate logistic analysis identified CRS ≥ 0.2 as a significant determinant of postoperative complications (p < 0.01; hazard ratio, 4.84). Overall survival was significantly better in the CRS < 0.2 group than in the CRS > 0.2 group (p < 0.01).

Conclusions

The E-PASS score system was a useful predictor of postoperative complications and mortality, especially in patients with advanced age.
Literature
1.
go back to reference Teriokhin AT, Budilova EV, Thomas F, Guegan JF (2004) World wide variation in life-span sexual dimorphism and sex-specific environmental mortality rates. Hum Biol 76:623–641CrossRefPubMed Teriokhin AT, Budilova EV, Thomas F, Guegan JF (2004) World wide variation in life-span sexual dimorphism and sex-specific environmental mortality rates. Hum Biol 76:623–641CrossRefPubMed
2.
go back to reference Bottino V, Esposite MG, Mottola A et al (2012) Early outcomes of colon laparoscopic resection in the elderly patients compared with the younger. BMG Surg 12:58–61. doi:10.1186/1471-2482-12-S1-S8 Bottino V, Esposite MG, Mottola A et al (2012) Early outcomes of colon laparoscopic resection in the elderly patients compared with the younger. BMG Surg 12:58–61. doi:10.​1186/​1471-2482-12-S1-S8
4.
5.
go back to reference Neuman HB, O’Connor ES, Weiss J, Loconte NK, Greenberg CC, Smith MA (2013) Surgical treatment of colon cancer in patients aged 80 years and older. Cancer 1:639–647. doi:10.1002/cncr.27765 CrossRef Neuman HB, O’Connor ES, Weiss J, Loconte NK, Greenberg CC, Smith MA (2013) Surgical treatment of colon cancer in patients aged 80 years and older. Cancer 1:639–647. doi:10.​1002/​cncr.​27765 CrossRef
8.
go back to reference Savlovschi C, Serban D, Trotea T, Borcan R, Dumitrescu D (2013) Post-surgery morbidity and mortality in colorectal cancer in elderly subjects. Chirurgia 108:177–179PubMed Savlovschi C, Serban D, Trotea T, Borcan R, Dumitrescu D (2013) Post-surgery morbidity and mortality in colorectal cancer in elderly subjects. Chirurgia 108:177–179PubMed
9.
go back to reference Ariake K, Ueno T, Takahashi M et al (2014) E-PASS comprehensive risk score is a good predictor of postsurgical mortality from comorbid disease in elderly gastric cancer patients. J Surg Oncol 109:586–592. doi:10.1002/jso.23542 CrossRefPubMed Ariake K, Ueno T, Takahashi M et al (2014) E-PASS comprehensive risk score is a good predictor of postsurgical mortality from comorbid disease in elderly gastric cancer patients. J Surg Oncol 109:586–592. doi:10.​1002/​jso.​23542 CrossRefPubMed
11.
go back to reference Krarup PM, Nordholm-Carstensen A, Jorgensen LN, Harling H (2014) Anastomotic leak increases distant recurrence and long-term mortality after curative resection for colonic cancer: a nationwide cohort study. Ann Surg 259:930–938. doi:10.1097/SLA.0b013e3182a6f2fc CrossRefPubMed Krarup PM, Nordholm-Carstensen A, Jorgensen LN, Harling H (2014) Anastomotic leak increases distant recurrence and long-term mortality after curative resection for colonic cancer: a nationwide cohort study. Ann Surg 259:930–938. doi:10.​1097/​SLA.​0b013e3182a6f2fc​ CrossRefPubMed
15.
go back to reference Tekkis PP, Prytherch DR, Kocher HM et al (2004) Development of dedicated risk-adjustment scoring system for colorectal surgery. Br J Surg 115:1174–1182CrossRef Tekkis PP, Prytherch DR, Kocher HM et al (2004) Development of dedicated risk-adjustment scoring system for colorectal surgery. Br J Surg 115:1174–1182CrossRef
16.
go back to reference Onodera I, Goseki N, Kosaki G (1984) Prognostic nutrition index in gastrointestinal surgery of malnourished cancer patients. Nohon Geka Gakkai Zassi 105:1001–1005 Onodera I, Goseki N, Kosaki G (1984) Prognostic nutrition index in gastrointestinal surgery of malnourished cancer patients. Nohon Geka Gakkai Zassi 105:1001–1005
17.
go back to reference Haga Y, Ikei S, Ogawa M (1999) Estimation of Physiologic Ability and Surgical Stress (E-PASS) as a new prediction scoring system for postoperative morbidity and mortality following elective gastrointestinal surgery. Surg Today 29:219–225. doi:10.1007/s005950050392 CrossRefPubMed Haga Y, Ikei S, Ogawa M (1999) Estimation of Physiologic Ability and Surgical Stress (E-PASS) as a new prediction scoring system for postoperative morbidity and mortality following elective gastrointestinal surgery. Surg Today 29:219–225. doi:10.​1007/​s005950050392 CrossRefPubMed
18.
go back to reference Hattori H, Kamiya J, Shimada H et al (2009) Assessment of the risk of postoperative delirium in elderly patients using E-PASS and the NEECHAM Confusion Scale. Int J Gariatr Psychiatry 24:1304–1310. doi:10.1002/gps.2262 CrossRef Hattori H, Kamiya J, Shimada H et al (2009) Assessment of the risk of postoperative delirium in elderly patients using E-PASS and the NEECHAM Confusion Scale. Int J Gariatr Psychiatry 24:1304–1310. doi:10.​1002/​gps.​2262 CrossRef
20.
go back to reference Ren L, Upadhyay AM, Wang L, Li L, Lu J, Fu W (2009) Mortality rate prediction by Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM), Portsmouth POSSUM and Colorectal POSSUM and the development of new scoring systems in Chinese colorectal cancer patients. Clin Surg Int 198:31–38. doi:10.1016/j.amjsurg.2008.06.044 Ren L, Upadhyay AM, Wang L, Li L, Lu J, Fu W (2009) Mortality rate prediction by Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM), Portsmouth POSSUM and Colorectal POSSUM and the development of new scoring systems in Chinese colorectal cancer patients. Clin Surg Int 198:31–38. doi:10.​1016/​j.​amjsurg.​2008.​06.​044
21.
go back to reference Prytherch DR, Whiteley MS, Higgins B, Weaver PC, Prout WG, Powell SJ (1998) POSSUM and Portsmouth POSSUM for predicting mortality. Physiological and operative severity score for the enumeration of mortality and morbidity. Br J Surg 85:1217–1220CrossRefPubMed Prytherch DR, Whiteley MS, Higgins B, Weaver PC, Prout WG, Powell SJ (1998) POSSUM and Portsmouth POSSUM for predicting mortality. Physiological and operative severity score for the enumeration of mortality and morbidity. Br J Surg 85:1217–1220CrossRefPubMed
23.
go back to reference Nozoe T, Kohno M, Iguchi T et al (2012) The prognostic nutritional index can be a prognostic indicator in colorectal carcinoma. Surg Today 42:532–535CrossRefPubMed Nozoe T, Kohno M, Iguchi T et al (2012) The prognostic nutritional index can be a prognostic indicator in colorectal carcinoma. Surg Today 42:532–535CrossRefPubMed
24.
go back to reference Watanabe T, Itabashi M, Shimada Y et al (2012) Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol 17:1–29CrossRefPubMed Watanabe T, Itabashi M, Shimada Y et al (2012) Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer. Int J Clin Oncol 17:1–29CrossRefPubMed
25.
go back to reference Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a surgery. Ann Surg 240:205–213PubMedCentralCrossRefPubMed Dindo D, Demartines N, Clavien PA (2004) Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a surgery. Ann Surg 240:205–213PubMedCentralCrossRefPubMed
27.
go back to reference Ulander K, Jappsson B, Gragn G (1997) Quality of life and independence in activities of daily living preoperatively and at follow-up patients with colorectal cancer. Support Care Cancer 5:402–409. doi:10.1007/s005200050099 CrossRefPubMed Ulander K, Jappsson B, Gragn G (1997) Quality of life and independence in activities of daily living preoperatively and at follow-up patients with colorectal cancer. Support Care Cancer 5:402–409. doi:10.​1007/​s005200050099 CrossRefPubMed
28.
go back to reference Nanashima A, Abo T, Nonaka T et al (2011) Prognosis of patients with hepatocellular carcinoma after hepatic resection: are elderly patients suitable for surgery? J Surg Oncol 104:284–291. doi:10.1002/jso.21932 CrossRefPubMed Nanashima A, Abo T, Nonaka T et al (2011) Prognosis of patients with hepatocellular carcinoma after hepatic resection: are elderly patients suitable for surgery? J Surg Oncol 104:284–291. doi:10.​1002/​jso.​21932 CrossRefPubMed
29.
go back to reference Hashimoto D, Takamori H, Hirotaz M, Baba H (2013) Prediction of operative morbidity after pancreatic resection. Hepatogastroenterology 60:1577–1582PubMed Hashimoto D, Takamori H, Hirotaz M, Baba H (2013) Prediction of operative morbidity after pancreatic resection. Hepatogastroenterology 60:1577–1582PubMed
31.
go back to reference Haga Y, Yagi Y, Ogawa M (1999) Less-invasive surgery for gastric cancer prolongs survival in patients over 80 years of age. Surg Today 29:842–848CrossRefPubMed Haga Y, Yagi Y, Ogawa M (1999) Less-invasive surgery for gastric cancer prolongs survival in patients over 80 years of age. Surg Today 29:842–848CrossRefPubMed
32.
go back to reference Stephen JB, William JC (2006) Validation of the CR-POSSUM risk-adjusted scoring system for major colorectal cancer surgery in a single center. Dis Colon Rectum 50:192–196 Stephen JB, William JC (2006) Validation of the CR-POSSUM risk-adjusted scoring system for major colorectal cancer surgery in a single center. Dis Colon Rectum 50:192–196
33.
go back to reference Senagore AJ, Warmuth AJ, Delaney CP, Tekkis PP, Fazio VW (2004) POSSUM, p-POSSUM, and Cr-POSSUM: implementation issues in a United States health care system for prediction of outcome for colon cancer resection. Dis Colon Rectum 47:1435–1441. doi:10.1007/s10350-004-0604-1 CrossRefPubMed Senagore AJ, Warmuth AJ, Delaney CP, Tekkis PP, Fazio VW (2004) POSSUM, p-POSSUM, and Cr-POSSUM: implementation issues in a United States health care system for prediction of outcome for colon cancer resection. Dis Colon Rectum 47:1435–1441. doi:10.​1007/​s10350-004-0604-1 CrossRefPubMed
34.
go back to reference Nozoe T, Kimura Y, Ishida M, Saeki H, Korenaga D, Sugimachi K (2002) Correlation of pre-operative nutritional condition with post-operative complications in surgical treatment for esophageal carcinoma. Eur J Surg 28:396–400CrossRef Nozoe T, Kimura Y, Ishida M, Saeki H, Korenaga D, Sugimachi K (2002) Correlation of pre-operative nutritional condition with post-operative complications in surgical treatment for esophageal carcinoma. Eur J Surg 28:396–400CrossRef
35.
go back to reference Ionescu D, Tibrea C, Puia C (2013) Pre-operative hypoalbuminemia in colorectal cancer patients undergoing elective surgery-a major risk factor for postoperative outcome. Chirurgia 108:822–828PubMed Ionescu D, Tibrea C, Puia C (2013) Pre-operative hypoalbuminemia in colorectal cancer patients undergoing elective surgery-a major risk factor for postoperative outcome. Chirurgia 108:822–828PubMed
37.
go back to reference Ji FF, Ying H, Jin SL (2013) Combination of neutrophil lymphocyte ratio and platelet lymphocyte ratio is a useful predictor of postoperative survival in patients with esophageal squamous cell carcinoma. Onco Targets Ther 6:1605–1612 Ji FF, Ying H, Jin SL (2013) Combination of neutrophil lymphocyte ratio and platelet lymphocyte ratio is a useful predictor of postoperative survival in patients with esophageal squamous cell carcinoma. Onco Targets Ther 6:1605–1612
38.
go back to reference He W, Yin C, Guo G et al (2013) Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer. Med Oncol 30:439–445. doi:10.1007/s12032-012-0439-x CrossRefPubMed He W, Yin C, Guo G et al (2013) Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer. Med Oncol 30:439–445. doi:10.​1007/​s12032-012-0439-x CrossRefPubMed
41.
go back to reference Lagarde SM, de Boer JD, ten Kate FJ, Busch OR, Obertop H, van Lanschot JJ (2008) Postoperative complications after esophagectomy for adenocarcinoma of the esophagus are related to timing of death due to recurrence. Ann Surg 247:71–76. doi:10.1097/SLA.0b013e31815b695e CrossRefPubMed Lagarde SM, de Boer JD, ten Kate FJ, Busch OR, Obertop H, van Lanschot JJ (2008) Postoperative complications after esophagectomy for adenocarcinoma of the esophagus are related to timing of death due to recurrence. Ann Surg 247:71–76. doi:10.​1097/​SLA.​0b013e31815b695e​ CrossRefPubMed
42.
go back to reference Tsujimoto H, Ichikura T, Ono S et al (2009) Impact of postoperative infection on lomg term survival after potentially curative resection for gastric cancer. Ann Surg Oncol 16:311–318CrossRefPubMed Tsujimoto H, Ichikura T, Ono S et al (2009) Impact of postoperative infection on lomg term survival after potentially curative resection for gastric cancer. Ann Surg Oncol 16:311–318CrossRefPubMed
43.
go back to reference Bakker IS, Grossmann I, Henneman D, Havendga K, Wiggers T (2014) Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit. Br J Surg 101:424–432. doi:10.1002/bjs.9395 CrossRefPubMed Bakker IS, Grossmann I, Henneman D, Havendga K, Wiggers T (2014) Risk factors for anastomotic leakage and leak-related mortality after colonic cancer surgery in a nationwide audit. Br J Surg 101:424–432. doi:10.​1002/​bjs.​9395 CrossRefPubMed
Metadata
Title
E-PASS score as a useful predictor of postoperative complications and mortality after colorectal surgery in elderly patients
Authors
Tetsuro Tominaga
Hiroaki Takeshita
Katsunori Takagi
Masaki Kunizaki
Kazuo To
Takafumi Abo
Shigekazu Hidaka
Atsushi Nanashima
Takeshi Nagayasu
Terumitsu Sawai
Publication date
01-02-2016
Publisher
Springer Berlin Heidelberg
Published in
International Journal of Colorectal Disease / Issue 2/2016
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-015-2456-7

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