Published in:
Open Access
01-02-2011 | Poster presentation
Dysregulation of immune monocyte responses during sepsis
Authors:
D Fiume, G Caiazza, V Tsekeuli, A Sinistro, C Almerighi, F Calo'-Carducci, E Baffari, A Bergamini, S Natoli, F Leonardis
Published in:
Critical Care
|
Special Issue 1/2011
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Excerpt
Despite intense efforts, sepsis remains a serious clinical problem, accounting for thousands of deaths every year. Many findings have shown that immune dysfunction in septic patients plays a very important role. Thus, a better understanding of the basic immune alterations in sepsis is needed to appropriately direct therapy. Here we sequentially measured TNFα, IL-1B, IL-6 and IL-10 de novo synthesis by monocytes via multiparametric flow cytometry and monocyte expression of surface molecules that allow effective antigen presentation, in patients with severe sepsis and septic shock up to 12 days after admission. …
