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European Archives of Oto-Rhino-Laryngology

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Open Access 01-03-2019 | Dysphonia | Laryngology

Quality of life and voice outcome of patients treated with transoral CO₂ laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study

Authors: Martine Hendriksma, Yda van Loon, W. Martin C. Klop, Marieke M. Hakkesteegt, Bas J. Heijnen, Ibtissam el Hasnaoui, Martin de Jong, Ton P. M. Langeveld, Peter Paul G. van Benthem, Robert J. Baatenburg de Jong, Elisabeth V. Sjögren

Published in: European Archives of Oto-Rhino-Laryngology | Issue 3/2019

Abstract

Purpose

Longitudinal studies in laryngeal cancer can provide clinicians information about short-term and long-term functional outcomes, like quality of life (QoL) and voice outcome. This information is important when counseling patients or choosing a primary treatment modality. The present study assessed long-term (2 years) QoL and voice outcome in patients with extended T1 and limited T2 glottic carcinoma treated with transoral CO₂ laser microsurgery (TLM) (unilateral type III or bilateral type II resections).

Methods

Three questionnaires were administered: the Voice Handicap Index (VHI), the European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaire (QLQ)-C30, the EORTC QLQ-HN35. A perceptual voice evaluation at six different time points was conducted: preoperatively, and postoperatively at 6 weeks, 3 months, 6 months, 1 year, and 2 years. Fluctuations over time were investigated.

Results

Sixty-one patients were included in the analysis. Patients reported high-level functioning and low symptom scores 2 years postoperatively. Gender significantly affected the VHI scores at 2 years (mean VHI scores: female 8.7 vs. male, 23.9; p = 0.023). The major improvement in VHI scores was observed within the first 6 months. The tumor stage (T1a, T1b, and T2) significantly impacted the grade (mean scores at 2 years: 1.0, 1.9, and 1.7; p = 0.001). These scores stabilized at 6 months.

Conclusions

Patients show good long-term QoL with low symptom scores, a low voice handicap, and mild to moderate dysphonia, 2 years postoperatively. Scores stabilize at 6 months and provide a clear indication of status at 1 and 2 years.

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Title: Quality of life and voice outcome of patients treated with transoral CO2 laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study
Authors: Martine Hendriksma
Yda van Loon
W. Martin C. Klop
Marieke M. Hakkesteegt
Bas J. Heijnen
Ibtissam el Hasnaoui
Martin de Jong
Ton P. M. Langeveld
Peter Paul G. van Benthem
Robert J. Baatenburg de Jong
Elisabeth V. Sjögren
Publication date: 01-03-2019
Publisher: Springer Berlin Heidelberg
Keywords: Dysphonia
Glottic Carcinoma
CO2 Laser
Dysphonia
Laryngeal Cancer
Laryngeal Cancer
Published in: European Archives of Oto-Rhino-Laryngology / Issue 3/2019
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-019-05348-1

At a glance: The STEP trials

Springer Medicine

Quality of life and voice outcome of patients treated with transoral CO₂ laser microsurgery for early glottic carcinoma (T1–T2): a 2-year follow-up study

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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