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AIDS Research and Therapy
Published in: AIDS Research and Therapy 1/2012

Open Access 01-12-2012 | Review

Dual role of autophagy in HIV-1 replication and pathogenesis

Author: M Scott Killian

Published in: AIDS Research and Therapy | Issue 1/2012

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Abstract

Autophagy, the major mechanism for degrading long-lived intracellular proteins and organelles, is essential for eukaryotic cell homeostasis. Autophagy also defends the cell against invasion by microorganisms and has important roles in innate and adaptive immunity. Increasingly evident is that HIV-1 replication is dependent on select components of autophagy. Fittingly, HIV-1 proteins are able to modulate autophagy to maximize virus production. At the same time, HIV-1 proteins appear to disrupt autophagy in uninfected cells, thereby contributing to CD4+ cell death and HIV-1 pathogenesis. These observations allow for new approaches for the treatment and possibly the prevention of HIV-1 infection. This review focuses on the relationship between autophagy and HIV-1 infection. Discussed is how autophagy plays dual roles in HIV-1 replication and HIV-1 disease progression.
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Metadata
Title
Dual role of autophagy in HIV-1 replication and pathogenesis
Author
M Scott Killian
Publication date
01-12-2012
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2012
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/1742-6405-9-16

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