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European Radiology

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01-01-2015 | Magnetic Resonance

DTI for the assessment of disease stage in patients with glomerulonephritis - correlation with renal histology

Authors: Qiang Feng, Zhijun Ma, Jianlin Wu, Wei Fang

Published in: European Radiology | Issue 1/2015

Abstract

Objectives

To investigate whether DTI allows assessment of renal impairment and pathology in patients with chronic glomerulonephritis.

Materials and methods

Seventy-five patients and 20 healthy volunteers were enrolled in this study. Renal function and kidney biopsies were evaluated. For DTI, a respiratory-triggered coronal EPI sequence was performed (TR, 1400 ms; TE, 76 ms; diffusion direction, 6; NEX, 4; b values, 0 and 600 s/mm2; slices thickness, 6 mm, with no intersection gap). Renal ADC and FA values were calculated and compared between the groups. Correlations between ADC/FA and histopathology were evaluated.

Results

ADC values decreased with increased stages. ADC differences in renal parenchyma at different disease stages were found, with the exception of the control group compared with stage 1 patients; similar results were obtained for FA. ADC values in the cortex and medulla in stage 1-3 patients were both statistically different, similar to the FA values. A significant negative correlation was found between the percentage of glomerulosclerosis and FA in the renal cortex (r = -0.74), similar to the degree of tubulointerstitial fibrosis with FA in the medulla (r = -0.76).

Conclusions

ADC and FA values are correlated with the degree of renal impairment, the percentage of glomerulosclerosis, and area of interstitial fibrosis.

Key Points

• DTI can be used to assess renal function impairment in patients with chronic glomerulonephritis.

• ADC and FA values were correlated with tubulointerstitial fibrosis and glomerulosclerosis.

• Identification of renal impairment is helpful for timely treatment.

• DTI can be used for non-invasive assessment of renal pathology.

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Title: DTI for the assessment of disease stage in patients with glomerulonephritis - correlation with renal histology
Authors: Qiang Feng
Zhijun Ma
Jianlin Wu
Wei Fang
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 1/2015
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-014-3336-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

DTI for the assessment of disease stage in patients with glomerulonephritis - correlation with renal histology

Abstract

Objectives

Materials and methods

Results

Conclusions

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Key Points

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