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At a glance: The STEP trials

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Journal of Inflammation
Published in: Journal of Inflammation 1/2013

Open Access 01-08-2013 | Poster presentation

Dry powder inhaled compound delivery for early pre-clinical in vivo efficacy studies

Authors: Robert Ives, Lindsay Butterfield, John Farr, Shaun Bater, Tony Nials, Lewis Entwistle, Doug Ball, Edith Hessel

Published in: Journal of Inflammation | Special Issue 1/2013

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Excerpt

Inhaled dry powders are the preferred route of delivery for many respiratory medicines. Toxicology studies are routinely carried out on inhaled dry powders whereas early pre-clinical in vivo efficacy studies often use aqueous formulations. Ideally evaluation of in- vivo efficacy, duration of action and DMPK of novel compounds, delivered as dry powders, should be carried out at an earlier stage in the drug development process. This would allow direct comparisons to be made with toxicology data to establish a therapeutic index and enable a more relevant prediction of clinical efficacy. …
Metadata
Title
Dry powder inhaled compound delivery for early pre-clinical in vivo efficacy studies
Authors
Robert Ives
Lindsay Butterfield
John Farr
Shaun Bater
Tony Nials
Lewis Entwistle
Doug Ball
Edith Hessel
Publication date
01-08-2013
Publisher
BioMed Central
Published in
Journal of Inflammation / Issue Special Issue 1/2013
Electronic ISSN: 1476-9255
DOI
https://doi.org/10.1186/1476-9255-10-S1-P36

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Obesity Clinical Trial Summary

At a glance: The STEP trials

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A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

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