Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Current Infectious Disease Reports
Published in: Current Infectious Disease Reports 3/2010

01-05-2010

Drug-Resistant Malaria: The Era of ACT

Authors: Jessica T. Lin, Jonathan J. Juliano, Chansuda Wongsrichanalai

Published in: Current Infectious Disease Reports | Issue 3/2010

Login to get access

Abstract

As drug-resistant falciparum malaria has continued to evolve and spread worldwide, artemisinin-based combination therapies (ACT) have become the centerpiece of global malaria control over the past decade. This review discusses how advances in antimalarial drug resistance monitoring and rational use of the array of ACTs now available can maximize the impact of this highly efficacious therapy, even as resistance to artemisinins is emerging in Southeast Asia.
Literature
1.
Trape JF: The public health impact of chloroquine resistance in Africa. Am J Trop Med Hyg 2001, 64:127.
2.
World Health Organization: Methods for Surveillance of Antimalarial Drug Efficacy. Geneva: World Health Organization; 2009.
3.
Laufer MK: Monitoring antimalarial drug efficacy: current challenges. Curr Infect Dis Rep 2009,11:59–65.CrossRefPubMed
4.
Price RN, Uhlemann AC, Brockman A, et al.: Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 2004, 364:438–447.CrossRefPubMed
5.
Lim P, Alker AP, Khim N, et al.: Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia. Malar J 2009, 8:11.CrossRefPubMed
6.
Picot S, Olliaro P, de Monbrison F, et al.: A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria. Malar J 2009, 8:89.CrossRefPubMed
7.
Raj DK, Mu J, Jiang H, et al.: Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione. J Biol Chem 2009, 284:7687–7696.CrossRefPubMed
8.
Dahlström S, Ferreira PE, Veiga MI, et al.: Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa. J Infect Dis 2009, 200:1456–1464.CrossRefPubMed
9.
Korsinczky M, Chen N, Kotecka B, et al.: Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site. Antimicrob Agents Chemother 2000, 44:2100–2108.CrossRefPubMed
10.
Mita T, Tanabe K, Kita K: Spread and evolution of Plasmodium falciparum drug resistance. Parasitol Int 2009, 58:201–209.CrossRefPubMed
11.
• Plowe CV: The evolution of drug-resistant malaria. Trans R Soc Trop Med Hyg 2009, 103:S11–S14. This article is a concise and telling account of how genetic studies have shed light on the historical spread of drug-resistant malaria, with lessons learned for the future.CrossRefPubMed
12.
Roper C, Pearce R, Nair S, et al.: Intercontinental spread of pyrimethamine-resistant malaria. Science 2004, 305:1124.CrossRefPubMed
13.
World Health Organization: Guidelines for the treatment of malaria. Geneva: World Health Organization; 2006.
14.
Sibley CH, Barnes KI, Plowe CV: The rationale and plan for creating a World Antimalarial Resistance Network (WARN). Malar J 2007, 6:118.CrossRefPubMed
15.
Wongsrichanalai C, Pickard AL, Wernsdorfer WH, Meshnick SR: Epidemiology of drug-resistant malaria. Lancet Infect Dis 2002, 2:209–218.CrossRefPubMed
16.
Ringwald, Pascal: Susceptibility of Plasmodium falciparum to antimalarial drugs: report on global monitoring 1996–2004. Geneva: World Health Organization; 2005.
17.
World Health Organization: Antimalarial drug combination therapy: report of a WHO technical consultation, 4–5 April 2001. Geneva: World Health Organization; 2001.
18.
World Health Organization: World Malaria Report 2008. Geneva: World Health Organization; 2008.
19.
World Health Organization: World Malaria Report 2009. Geneva: World Health Organization, 2009.
20.
21.
22.
•• White NJ: Qinghaosu (artemisinin): the price of success. Science 2008, 320:330–334. This article is an excellent review of artemisinin and the unique pharmacologic properties that make it a promising weapon in malaria elimination.CrossRefPubMed
23.
Sutherland C, Drakeley CJ, Obisike U, et al.: The addition of artesunate to chloroquine for treatment of Plasmodium falciparum malaria in Gambian children delays, but does not prevent treatment failure. Am J Trop Hyg 2003, 69:19–25.
24.
Sinclair D, Zani B, Donegan S, et al.: Artemisinin-based combination therapy for treating uncomplicated malaria. Cochrane Database Syst Rev 2009, CD007483.
25.
Price RN, Nosten F, Luxemburger C, et al.: Effects of artemisinin derivatives on malaria transmissibility. Lancet 1996, 347:1654–1658.CrossRefPubMed
26.
Nosten F, White NJ: Artemisinin-based combination treatment of falciparum malaria. Am J Trop Med Hyg 2007, 77:181–192.PubMed
27.
Denis MB, Tsuyuoka R, Lim P, et al.: Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia. Trop Med Int Health 2006, 11:1800–1807.CrossRefPubMed
28.
Kamya MR, Yeka A, Bukirwa H, et al.: Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. PLoS Clin Trials 2007, 2:e20.CrossRefPubMed
29.
Sisowath C, Ferreira PE, Bustamante LY, et al.: The role of pfmdr1 in Plasmodium falciparum tolerance to artemether-lumefantrine in Africa. Trop Med Int Health 2007, 12:736–742.PubMedCrossRef
30.
Piola P, Fogg C, Bajunirwe F, et al.: Supervised versus unsupervised intake of six-dose artemether-lumefantrine for treatment of acute, uncomplicated Plasmodium falciparum malaria in Mbarara, Uganda: a randomised trial. Lancet 2005, 365:1467–1473.CrossRefPubMed
31.
Bell DJ, Wootton D, Mukaka M, et al.: Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi. Malar J 2009, 8:204.CrossRefPubMed
32.
McGready R, Tan SO, Ashley EA, et al.: A randomised controlled trial of artemether-lumefantrine versus artesunate for uncomplicated Plasmodium falciparum treatment in pregnancy. PLoS Med 2008, 5:e253.CrossRefPubMed
33.
Abdulla S, Sagara I, Borrmann S, et al.: Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial. Lancet 2008, 372:1819–1827.CrossRefPubMed
34.
Olliaro P, Mussano P: Amodiaquine for treating malaria. Cochrane Database Syst Rev 2003, CD000016.
35.
Müller O, Sié A, Meissner P, et al.: Comment on: artemisinin resistance on the Thai-Cambodian border. Lancet. 2009, 374:1419.CrossRefPubMed
36.
Gasasira AF, Kamya MR, Achan J, et al.: High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis 2008, 46:985–991.CrossRefPubMed
37.
Oesterholt MJ, Alifrangis M, Sutherland CJ, et al.: Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya. PLoS One 2009, 4:e4364.CrossRefPubMed
38.
Myint HY, Ashley EA, Daya NPJ, et al.: Effiacy and safety of dihydroartemisinin-piperaquine. Trans R Soc Trop Med Hyg 2007, 101: 858–866.CrossRefPubMed
39.
White NJ, Pongtavornpinyo W, Maude RJ, et al.: Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance. Malar J 2009, 8:253.CrossRefPubMed
40.
• Newton PN, Fernández FM, Plançon A, et al.: A collaborative epidemiological investigation into the criminal fake artesunate trade in South East Asia. PLoS Med 2008, 5:e32. This article provides an eye-opening account of widespread counterfeit activities that are threatening efforts to contain artemisinin resistance.CrossRefPubMed
41.
Bukirwa H, Critchley J: Sulfadoxine-pyrimethamine plus artesunate versus sulfadoxine-pyrimethamine plus amodiquine for treating uncomplicated malaria. Cochrane Database Syst Rev 2006:CD004966.
42.
Achan J, Tibenderana JK, Kyabayinze D, et al.: Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomized trial. BMJ 2009, 339:b2763.CrossRefPubMed
43.
Yeka A, Achan J, D’Alessandro U, et al.: Quinine monotherapy for treating uncomplicated malaria in the era of artemisinin-based combination therapy: an appropriate public health policy? Lancet Infect Dis 2009, 9:448–442.CrossRefPubMed
44.
World Health Organization: Global malaria control and elimination: report of a meeting on containment of artemisinin tolerance. Geneva: World Health Organization 2008.
45.
• Wongsrichanalai C, Meshnick SR: Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border. Emerg Infect Dis 2008, 14:716–719. This article summarizes the earliest evidence of artesunate-mefloquine failure on the Cambodian-Thai border and provides a critical discussion of possible factors contributing to the development of ACT resistance.CrossRefPubMed
46.
Vijaykadga S, Alker AP, Tongkong D, et al.: Delayed P. falciparum parasite clearance following artesunate-mefloquine combination therapy in Thailand, 1997–2007 [abstract 1119]. Presented at the American Society of Tropical Medicine and Hygiene 57th Annual Meeting. New Orleans, LA, USA; December 7–11, 2008.
47.
Lim P, Wongsrichanalai C, Chim P, et al.: Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007. Antimicrob Agents Chemother 2010, 54(5). doi:10.​1128/​AAC.​01304-09.
48.
•• Dondorp AM, Nosten F, Yi Po, et al.: Artemisinin Resistance in Plasmodium falciparum Malaria. N Eng J Med 2009, 361:455–467. This article presents the first evidence of significant artemisinin resistance in western Cambodia based on an artemisinin monotherapy trial, thus supporting earlier observations of artesunate-mefloquine failure.CrossRef
49.
Noedl H, Se Y, Schaecher K, et al.: Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med 2008, 359:2619–2620.CrossRefPubMed
50.
Se Y, Lon C, Socheat D, et al.: Effects of increasing artesunate dose in seven-day monotherapy regimens on treatment response in Cambodian patients with uncomplicated falciparum malaria [abstract 22]. Presented at the American Society of Tropical Medicine and Hygiene 58th Annual Meeting. Washington, DC, USA; November 18–22, 2009.
51.
Bethell D, Se Y, Lon C, et al.: Dose-dependent risk of neutropenia following seven-day courses of artesunate monotherapy in adult Cambodian patients with acute falciparum malaria [abstract 858]. Presented at the American Society of Tropical Medicine and Hygiene 58th Annual Meeting. Washington, DC, USA; November 18–22, 2009.
52.
Karbwang J, Na-Bangchang K, Congpoung K, et al.: Pharmacokinetics of oral artesunate in Thai patients with uncomplicated falciparum malaria. Clin Drug Investig 1998, 15:37–43.CrossRefPubMed
53.
Stepniewska K, Ashley E, Lee SJ, et al.: In vivo parasitological measures of artemisinin susceptibility. J Infect Dis 2010, 201:570–9.CrossRefPubMed
54.
Mu J, Myers RA, Jiang H, et al: Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs. Nat Genet 2010, 42:268–71.CrossRefPubMed
55.
• Olliaro P, Wells TN: The global portfolio of new antimalarial medicines under development. Clin Pharmacol Ther 2009, 85:584–595. This article provides a comprehensive review of new antimalarials in the clinical and preclinical phases of development and their potential impact on malaria control and elimination.CrossRefPubMed
Metadata
Title
Drug-Resistant Malaria: The Era of ACT
Authors
Jessica T. Lin
Jonathan J. Juliano
Chansuda Wongsrichanalai
Publication date
01-05-2010
Publisher
Current Science Inc.
Published in
Current Infectious Disease Reports / Issue 3/2010
Print ISSN: 1523-3847
Electronic ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-010-0099-y

Other articles of this Issue 3/2010

Current Infectious Disease Reports 3/2010 Go to the issue

ReviewPaper

Diagnosing Vaginal Infections: It’s Time to Join the 21st Century

ReviewPaper

New Vaccines for Japanese Encephalitis

Clinical Trials Report

Clinical Trials Report: Progress Toward an Effective Malaria Vaccine: RTS,S/ASO1B and RTS,S/ASO2A

ReviewPaper

Aspergillus Infections in the Head and Neck

ReviewPaper

Influenza in Travelers: Epidemiology, Risk, Prevention, and Control Issues

ReviewPaper

Global Impact of Multidrug-Resistant Pulmonary Tuberculosis Among HIV-Infected and Other Immunocompromised Hosts: Epidemiology, Diagnosis, and Strategies for Management
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits