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Neuropsychology Review
Published in: Neuropsychology Review 2/2009

01-06-2009 | Review

Drug Abuse and Hepatitis C Infection as Comorbid Features of HIV Associated Neurocognitive Disorder: Neurocognitive and Neuroimaging Features

Authors: Eileen M. Martin-Thormeyer, Robert H. Paul

Published in: Neuropsychology Review | Issue 2/2009

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Abstract

Substance abuse and co-infection with hepatitis C (HCV) are two highly relevant determinants of neurocognitive and neuroimaging abnormalities associated with HIV. Substance abuse and HCV are common in the HIV population and there is increasing evidence that the CNS is directly compromised by these comorbid conditions via additive or synergistic processes. In this article we review the current literature regarding mechanisms of neuronal injury as well as the neuropsychological and neuroimaging signatures associated with substance abuse and HCV status among HIV patients. We discuss specific methodological challenges and threats to validity associated with studies of HIV and comorbid substance use disorders or HCV and review potential strategies for minimizing their confounding effects. Efforts to understand the interactions between HIV, substance abuse and HCV co-infection will lead to more complete models of neuropathogenesis of HIV and a greater understanding of the variability in neuropsychological expression of HIV Associated Neurocognitive Disorder.
Footnotes
1
These studies included only SDIs in order to demonstrate that additive effects of HIV could be detected reliably by theory-driven cognitive measures. These findings have paved the way for additional cognitive studies of non-SDI samples that are currently in progress in our laboratory.
 
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Metadata
Title
Drug Abuse and Hepatitis C Infection as Comorbid Features of HIV Associated Neurocognitive Disorder: Neurocognitive and Neuroimaging Features
Authors
Eileen M. Martin-Thormeyer
Robert H. Paul
Publication date
01-06-2009
Publisher
Springer US
Published in
Neuropsychology Review / Issue 2/2009
Print ISSN: 1040-7308
Electronic ISSN: 1573-6660
DOI
https://doi.org/10.1007/s11065-009-9101-6

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