Published in:
01-02-2004 | Poster presentation
Drotrecogin alfa (activated) reduces the plasma levels of N-terminal prohormone atrial natriuretic peptide and N-terminal prohormone brain natriuretic peptide as markers of cardiac depression in septic patients
Authors:
U Hoffmann, M Brückmann, C Liebetrau, S Lang, T Bertsch, M Borggrefe, C Putensen, S Schröder, K Haase
Published in:
Critical Care
|
Special Issue 1/2004
Login to get access
Excerpt
The family of natriuretic peptides comprises several structurally related 22–53 amino acid peptides, such as atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are vasoactive peptides that have vasodilator and diuretic properties and play an important role in cardiovascular homeostasis. The salutary cardiovascular effects of natriuretic peptides suggest that ANP and BNP have a pathophysiological significance in cardiac depression in septic patients. Aim of the present study was to determine plasma levels of the stable N-terminal prohormone forms of ANP (Nt-proANP) and BNP (Nt-proBNP) in septic patients treated with and without Drotrecogin alfa (activated). Troponin I (TNI) as a parameter for cardiac dysfunction was also evaluated. …
