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European Journal of Clinical Microbiology & Infectious Diseases
Published in: European Journal of Clinical Microbiology & Infectious Diseases 8/2015

01-08-2015 | Review

Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade

Authors: G. Meletis, D. Chatzidimitriou, N. Malisiovas

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 8/2015

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Abstract

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative nosocomial pathogens commonly carry one carbapenemase gene conferring resistance to carbapenems and other beta-lactam antibiotics. However, increasing reports show that double-carbapenemase-producing (DCP) and even multi-carbapenemase-producing (MCP) bacteria are emerging in some parts of the world, diminishing further, in some cases, the already limited treatment options. In the present review, the up-to-date reports of DCP and MCP isolates are summarized and concerns regarding their emergence are discussed.
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Metadata
Title
Double- and multi-carbapenemase-producers: the excessively armored bacilli of the current decade
Authors
G. Meletis
D. Chatzidimitriou
N. Malisiovas
Publication date
01-08-2015
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Clinical Microbiology & Infectious Diseases / Issue 8/2015
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI
https://doi.org/10.1007/s10096-015-2379-9

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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