Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 11/2014

01-11-2014 | Assisted Reproduction Technologies

Donor egg IVF model to assess ecological implications for ART success

Authors: Lubna Pal, Neiha Kidwai, Jehanzeb Kayani, William B. Grant

Published in: Journal of Assisted Reproduction and Genetics | Issue 11/2014

Login to get access

Abstract

Purpose

Environmental influences on reproductive success are recognized. We hypothesized that location of fertility clinics may influence treatment success and explored this hypothesis utilizing donor egg IVF (IVF) embryo transfer (ET) model.

Methods

Publicly accessible national registry data (Society for Assisted Reproductive Technology) on fresh & frozen (FET) ET cycles undertaken at participating clinics across North America (n = 444 IVF centers) for 2007 were utilized. Information on number of donor egg IVF cycles, live birth (LB) rate following fresh and frozen ET(FET), average number (#) of ET and IVF center's location, geographical coordinates (latitude, longitude, altitude), annualized average temperatures and midyear regional ultraviolet B (UVB) radiation intensity were obtained. Multivariable logistic regression analyses assessed relationship between LBR (in tertile and uppermost versus lesser quartiles) following fresh and FET with geographical coordinates (region and altitude of clinic location) and ecological influences (average temperature and midyear UVB intensity), adjusting for #ET and clinic experience with donor egg IVF.

Results

Average number of fresh ET, clinic location (region) and midyear UVB intensity were positive predictors of LBR following fresh ET, whereas altitude and annualized average regional temperature demonstrated an inverse relationship with LBR following fresh ET. For FET cycles, #ET, clinic region and altitude were positive determinants of increasing LBR’s. Annualized regional temperature and midyear UVB failed to demonstrate any relationship with LB following donor egg FET.

Conclusion

Our data suggest that ecological influences may relate to donor egg IVF cycle success. Future studies are needed to better elucidate the mechanisms that could explain the observed associations.
Appendix
Available only for authorised users
Literature
1.
Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. Lancet. 1978;2(8085):366.PubMedCrossRef
2.
3.
Ferraretti AP, Goossens V, de Mouzon J, Bhattacharya S, Castilla JA, Korsak V, et al. European IVF-monitoring (EIM); Consortium for European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2008: results generated from European registers by ESHRE. Hum Reprod. 2012;27(9):2571–84.PubMedCrossRef
4.
Wang J, Sauer MV. In vitro fertilization (IVF): a review of 3 decades of clinical innovation and technological advancement. Ther Clin Risk Manag. 2006;2(4):355–64.PubMedCentralPubMedCrossRef
5.
The Practice Committee of the American Society for Reproductive Medicine and the Practice Committee of the Society for Assisted Reproductive Technology. Recommendations for gamete and embryo donation: a committee opinion. Fertil Steril. 2012 Oct 17.
6.
7.
Borini A, Suriano R, Barberi M, Dal Prato L, Bulletti C. Oocyte donation programs: strategy for improving results. Ann N Y Acad Sci. 2011;1221:27–31.PubMedCrossRef
8.
Noyes N, Hampton BS, Berkeley A, Licciardi F, Grifo J, Krey L. Factors useful in predicting the success of oocyte donation: a 3-year retrospective study. Fertil Steril. 2001;76:92–7.PubMedCrossRef
9.
Soares SR, Velasco JA, Fernandez M, Bosch E, Remohí J, Pellicer A, et al. Clinical factors affecting endometrial receptiveness in oocyte donation cycles. Fertil Steril. 2008;89(3):491–501.PubMedCrossRef
10.
Zenke U, Chetkowski RJ. Transfer and uterine factors are the major recipient-related determinants of success with donor eggs. Fertil Steril. 2004;82(4):850–6.PubMedCrossRef
11.
12.
Grant WB. A review of the role of solar ultraviolet-B irradiance and vitamin D in reducing risk of dental caries. Dermatoendocrinol. 2011;3(3):193–8.PubMedCentralPubMedCrossRef
13.
Grant WB, Cannell JJ. Autism prevalence in the United States with respect to solar ultraviolet-B doses: An ecological study. Dermato-endocrinology. 2013;5:159–64.PubMedCentralPubMedCrossRef
14.
Guillette Jr LJ, Iguchi T. Ecology. Life in a contaminated world. Science. 2012;337(6102):1614–5.PubMedCrossRef
15.
Sloka S, Silva C, Pryse-Phillips W, Patten S, Metz L, Yong VW. A quantitative analysis of suspected environmental causes of MS. Can J Neurol Sci. 2011;38(1):98–105.PubMed
16.
17.
Legro RS, Sauer MV, Mottla GL, Richter KS, Li X, Dodson WC, et al. Effect of air quality on assisted human reproduction. Hum Reprod. 2010;25(5):1317–24.PubMedCrossRef
18.
Gillie O. The Scots' Paradox: can sun exposure, or lack of it, explain major paradoxes in epidemiology? Anticancer Res. 2012;32:237–48.PubMed
19.
20.
Cummings DR. Seasonal sunshine and vitamin D: a possible explanation for differences in European and United States birth patterns. Biodemography Soc Biol. 2010;56(2):105–22.PubMedCrossRef
21.
Stumpf WE, Denny ME. Vitamin D (soltriol), light, and reproduction. Am J Obstet Gynecol. 1989;161(5):1375–84. Review.PubMedCrossRef
22.
23.
Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, et al. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 2010;94(4):1314–9.PubMedCentralPubMedCrossRef
24.
Rudick B, Ingles S, Chung K, Stanczyk F, Paulson R, Bendikson K. Characterizing the influence of vitamin D levels on IVF outcomes. Hum Reprod. 2012;27(11):3321–7.PubMedCrossRef
25.
Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 2014;101:447–52.PubMedCrossRef
26.
Anifandis GM, Dafopoulos K, Messini CI, Chalvatzas N, Liakos N, Pournaras S, et al. Prognostic value of follicular fluid 25-OH vitamin D and glucose levels in the IVF outcome. Reprod Biol Endocrinol. 2010;8:91.PubMedCentralPubMedCrossRef
27.
Canto MT, Anderson WF, Brawley O. Geographic variation in breast cancer mortality for white and black women: 1986-1995. CA Cancer J Clin. 2001;51(6):367–70.PubMedCrossRef
28.
Elliott JC, Lucas RM, Clements MS, Bambrick HJ. Population density determines the direction of the association between ambient ultraviolet radiation and type 1 diabetes incidence. Pediatr Diabetes. 2010;11(6):394–402.PubMedCrossRef
29.
Grant WB, Garland CF. The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res. 2006;26(4A):2687–99.PubMed
30.
Grant WB. Ecological studies of the UVB-vitamin D-cancer hypothesis. Anticancer Res. 2012;32(1):223–36.PubMed
31.
Milo R, Kahana E. Multiple sclerosis: geoepidemiology, genetics and the environment. Autoimmun Rev. 2010;9(5):A387–94.PubMedCrossRef
32.
Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. 2008;51(8):1391–8.PubMedCrossRef
33.
Sariego J. Patterns of breast cancer presentation in the United States: does geography matter? Am Surg. 2009;75(7):545–9.PubMed
34.
Sturgeon SR, Schairer C, Gail M, McAdams M, Brinton LA, Hoover RN. Geographic variation in mortality from breast cancer among white women in the United States. J Natl Cancer Inst. 1995;87(24):1846–53.PubMedCrossRef
35.
Wei-Passanese EX, Han J, Lin W, Li T, Laden F, Qureshi AA. Geographical variation in residence and risk of multiple nonmelanoma skin cancers in US women and men. Photochem Photobiol. 2012;88(2):483–9.PubMedCrossRef
36.
Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. 2005;10(2):94–111. Review.PubMed
37.
38.
39.
Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004;80(6):1678S–88.PubMed
40.
41.
Grubesic TH, Matisziw TC. On the use of ZIP codes and ZIP code tabulation areas (ZCTAs) for the spatial analysis of epidemiological data. Int J Health Geogr. 2006;5:58.PubMedCentralPubMedCrossRef
42.
Hibbert JD, Liese AD, Lawson A, Porter DE, Puett RC, Standiford D, et al. Evaluating geographic imputation approaches for zip code level data: an application to a study of pediatric diabetes. Int J Health Geogr. 2009;8:54.PubMedCentralPubMedCrossRef
43.
Du H, Daftary GS, Lalwani SI, Taylor HS. Direct regulation of HOXA10 by 1,25-(OH)2D3 in human myelomonocytic cells and human endometrial stromal cells. Mol Endocrinol. 2005;19:2222–33.PubMedCrossRef
44.
Evans KN, Nguyen L, Chan J, Innes BA, Bulmer JN, Kilby MD, et al. Effects of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on cytokine production by human decidual cells. Biol Reprod. 2006;75(6):816–22.PubMedCrossRef
45.
Tavakoli M, Jeddi-Tehrani M, Salek-Moghaddam A, Rajaei S, Mohammadzadeh A, Sheikhhasani S, et al. Effect of 1,25(OH)(2) vitamin D(3) on cytokine production by endometrial cells of women with repeated implantation failure. Gynecol Endocrinol. 2012;28:906–11.PubMedCrossRef
46.
Lam DA, Miron JA. Seasonality of births in human populations. Soc Biol. 1991;3:51–78.
47.
Wood S, Quinn A, Troupe S, Kingsland C, Lewis-Jones I. Seasonal variation in assisted conception cycles and the influence of photoperiodism on outcome in in vitro fertilization cycles. Hum Fertil (Camb). 2006;9(4):223–9.CrossRef
48.
Barber N. On the Relationship Between Fertility and Geographic Latitude: A Cross-National Study. Cross-Cult Res. 2002;36:3–15.CrossRef
49.
Shapiro BS, Daneshmand ST, Garner FC, Aguirre M, Hudson C, Thomas S. Evidence of impaired endometrial receptivity after ovarian stimulation for in vitro fertilization: a prospective randomized trial comparing fresh and frozen-thawed embryo transfer in normal responders. Fertil Steril. 2011;96(2):344–8.PubMedCrossRef
50.
Rybak EA, Bevilacqua K, Veit CR, Klugman SD, Santoro N. Sibling and self ovum donation for sisters with an intermediate FMR1 mutation: what's a program to do? Fertil Steril. 2009;92:394.e9–394.e12.
51.
Bellver J, Pellicer A, García-Velasco JA, Ballesteros A, Remohí J, Meseguer M. Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors. Fertil Steril. 2013;100:1050–8.PubMedCrossRef
52.
Sunkara SK, Khairy M, El-Toukhy T, Khalaf Y, Coomarasamy A. The effect of intramural fibroids without uterine cavity involvement on the outcome of IVF treatment: a systematic review and meta-analysis. Hum Reprod. 2010;25:418–29.PubMedCrossRef
53.
Zenke U, Chetkowski RJ. Transfer and uterine factors are the major recipient-related determinants of success with donor eggs. Fertil Steril. 2004;82:850–6.PubMedCrossRef
54.
Cohen MA, Lindheim SR, Sauer MV. Hydrosalpinges adversely affect implantation in donor oocyte cycles. Hum Reprod. 1999;14:1087–9.PubMedCrossRef
Metadata
Title
Donor egg IVF model to assess ecological implications for ART success
Authors
Lubna Pal
Neiha Kidwai
Jehanzeb Kayani
William B. Grant
Publication date
01-11-2014
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 11/2014
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-014-0322-0

Other articles of this Issue 11/2014

Journal of Assisted Reproduction and Genetics 11/2014 Go to the issue

Fertility Preservation

Treatment history and outcome of 24 deliveries worldwide after autotransplantation of cryopreserved ovarian tissue, including two new Danish deliveries years after autotransplantation

Gamete Biology

Morphologic and proliferative characteristics of goat type a spermatogonia in the presence of different sets of growth factors

Gamete Biology

Sperm morphological abnormalities visualised at high magnification predict embryonic development, from fertilisation to the blastocyst stage, in couples undergoing ICSI

Editor’s Commentary

Perceptions of trophectoderm as a sentinel for embryo selection

Genetics

Aneuploidy across individual chromosomes at the embryonic level in trophectoderm biopsies: changes with patient age and chromosome structure

Erratum

Erratum to: Relationship between oxidative stress and clinical pregnancy in assisted reproductive technology treatment cycles