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Endocrine
Published in: Endocrine 1/2017

01-01-2017 | Editorial

Does testicular anti-Müllerian hormone extend life?

Authors: Ian S. McLennan, Yih Harng Chong

Published in: Endocrine | Issue 1/2017

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Excerpt

Men tend to have shorter lives than women, with the gonads appearing to contributing to this. Gonadal hormones decline from midlife in men, but few elderly men become totally devoid of testicular hormones, the male equivalent of menopause [1]. The systemic metabolic demands created by gonadal hormones are therefore more extended in men than women. When the testicular influence is lessened by castration at a young age, the resulting eunuchs typically outlive intact men by over a decade [2]. This supports the theory that the testes facilitate reproductive success, at the expensive of longevity. …
Literature
1.
Y.H. Chong, M.P. Pankhurst, I.S. McLennan, The testicular hormones AMH, inhb, insl3 and testosterone can be independently deficient in older men. J. Gerontol. A. (2016). doi:10.​1093/​gerona/​glw143
2.
J.D. Wilson, C. Roehrborn, Long-term consequences of castration in men: Lessons from the skoptzy and the eunuchs of the chinese and ottoman courts. J. Clin. Endocrinol. Metab. 84, 4324–4331 (1999)CrossRefPubMed
3.
R. Qayyum, S. Akbar, Serum anti-mullerian hormone and all-cause mortality in men. Endocrine 54, 225–231 (2016)CrossRefPubMed
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I.S. McLennan, M.W. Pankhurst, Anti-mullerian hormone is a gonadal cytokine with two circulating forms and cryptic actions. J. Endocrinol. 226, R45–R57 (2015)CrossRefPubMed
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N. Lebeurrier, S. Launay, R. Macrez, E. Maubert, H. Legros, A. Leclerc, S.P. Jamin, J.Y. Picard, S. Marret, V. Laudenbach, P. Berger, P. Sonderegger, C. Ali, N. di Clemente, D. Vivien, Anti-mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpin. J. Cell. Sci. 121, 3357–3365 (2008)CrossRefPubMed
Metadata
Title
Does testicular anti-Müllerian hormone extend life?
Authors
Ian S. McLennan
Yih Harng Chong
Publication date
01-01-2017
Publisher
Springer US
Published in
Endocrine / Issue 1/2017
Print ISSN: 1355-008X
Electronic ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-016-1162-8

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