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International Journal of Colorectal Disease

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01-12-2012 | Original Article

Does body mass index impact the number of LNs harvested and influence long-term survival rate in patients with stage III colon cancer?

Authors: Yi-Hung Kuo, Kam-Fai Lee, Chih-Chien Chin, Wen-Shih Huang, Chung-Hung Yeh, Jeng-Yi Wang

Published in: International Journal of Colorectal Disease | Issue 12/2012

Abstract

Background

The aim of this study is to evaluate whether different body mass index (BMI) values affect lymph node (LN) retrieval and whether such variations influence long–term survival in Asian patients.

Method

From January 1995 to July 2003, 645 stage III colon cancer patients were enrolled in our study. Patients were stratified into four groups: Obese (BMI ≧ 27 kg/m²), overweight (24 ≤ BMI < 27 kg/m²), normal (18.5 ≤ BMI < 24 kg/m²), and underweight (BMI < 18.5 kg/m²).

Results

Mean BMI in the cohort was 23.3 kg/m². Mean number of LNs harvested was 23.1, 19.5, 19.8 and 28.1 in the normal, overweight, obese and underweight groups, respectively. There was a significant difference in the mean number of LNs harvested when comparing the overweight and underweight groups to the normal group (p = 0.013 and p = 0.04, respectively). Females were overrepresented in the underweight group (p = 0.011), and patients who had proximal colon cancers were more frequently underweight (p = 0.018). The mean number of LNs harvested varied by cases of right hemicolectomy (p = 0.009) and proximal cancer location (p = 0.009) for different BMI groups. Multivariate analysis showed that underweight, proximal colon cancer, well- or moderately differentiated adenocarcinoma and stage IIIC cancer were significant variables for adequate LN recovery. BMI was not significantly associated with relapse-free survival (p = 0.523) or overall survival (p = 0.127).

Conclusion

BMI is associated with LN harvest but is not an independent variable in stage III colon cancer survival.

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Title: Does body mass index impact the number of LNs harvested and influence long-term survival rate in patients with stage III colon cancer?
Authors: Yi-Hung Kuo
Kam-Fai Lee
Chih-Chien Chin
Wen-Shih Huang
Chung-Hung Yeh
Jeng-Yi Wang
Publication date: 01-12-2012
Publisher: Springer-Verlag
Published in: International Journal of Colorectal Disease / Issue 12/2012
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-012-1496-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Does body mass index impact the number of LNs harvested and influence long-term survival rate in patients with stage III colon cancer?

Abstract

Background

Method

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusion

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