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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2016

Open Access 01-12-2016 | Review

Do early life factors affect the development of knee osteoarthritis in later life: a narrative review

Authors: Benny Antony, Graeme Jones, Xingzhong Jin, Changhai Ding

Published in: Arthritis Research & Therapy | Issue 1/2016

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Abstract

Osteoarthritis (OA) mainly affects older populations; however, it is possible that early life factors contribute to the development of OA in later life. The aim of this review is to describe the association between childhood or early adulthood risk factors and knee pain, structural imaging markers and development of knee OA in later life. A narrative overview of the literature synthesising the findings of literature retrieved from searches of computerised databases and manual searches was conducted. We found that only a few studies have explored the long-term effect of childhood or early adulthood risk factors on the markers of joint health that predispose people to OA or joint symptoms. High body mass index (BMI) and/or overweight status from childhood to adulthood were independently related to knee pain and OA in later life. The findings regarding the association between strenuous physical activity and knee structures in young adults are still conflicting. However, a favourable effect of moderate physical activity and fitness on knee structures is reported. Childhood physical activity and performance measures had independent beneficial effects on knee structures including knee cartilage in children and young adults. Anterior knee pain syndrome in adolescence could lead to the development of patellofemoral knee OA in the late 40s. Furthermore, weak evidence suggests that childhood malalignment, socioeconomic status and physical abuse are associated with OA in later life. The available evidence suggests that early life intervention may prevent OA in later life.
Literature
1.
2.
Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Guillemin F, Hill CL, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7):1323–30.CrossRefPubMed
3.
Global Burden of Disease Study C. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;386(9995):743–800.CrossRef
4.
Richmond SA, Fukuchi RK, Ezzat A, Schneider K, Schneider G, Emery CA. Are joint injury, sport activity, physical activity, obesity, or occupational activities predictors for osteoarthritis? A systematic review. J Orthop Sports Phys Ther. 2013;43(8):515–B19.CrossRefPubMed
5.
Fransen M, Simic M, Harmer AR. Determinants of MSK health and disability: lifestyle determinants of symptomatic osteoarthritis. Best Pract Res Clin Rheumatol. 2014;28(3):435–60.CrossRefPubMed
6.
Urquhart DM, Tobing JFL, Hanna FS, Berry P, Wluka AE, Ding C, Cicuttini FM. What is the effect of physical activity on the knee joint? A systematic review. Med Sci Sports Exerc. 2011;43(3):432–42.CrossRefPubMed
7.
Winsloe C, Earl S, Dennison EM, Cooper C, Harvey NC. Early life factors in the pathogenesis of osteoporosis. Curr Osteoporos Rep. 2009;7(4):140–4.CrossRefPubMed
8.
Pelletier JP, Cooper C, Peterfy C, Reginster JY, Brandi ML, Bruyere O, Chapurlat R, Cicuttini F, Conaghan PG, Doherty M, et al. What is the predictive value of MRI for the occurrence of knee replacement surgery in knee osteoarthritis? Ann Rheum Dis. 2013;72(10):1594–604.CrossRefPubMed
9.
Cohen ZA, Mow VC, Henry JH, Levine WN, Ateshian GA. Templates of the cartilage layers of the patellofemoral joint and their use in the assessment of osteoarthritic cartilage damage. Osteoarthritis Cartilage. 2003;11(8):569–79.CrossRefPubMed
10.
Burgkart R, Glaser C, Hinterwimmer S, Hudelmaier M, Englmeier KH, Reiser M, Eckstein F. Feasibility of T and Z scores from magnetic resonance imaging data for quantification of cartilage loss in osteoarthritis. Arthritis Rheum. 2003;48(10):2829–35.CrossRefPubMed
11.
Hunter DJ, Guermazi A, Roemer F, Zhang Y, Neogi T. Structural correlates of pain in joints with osteoarthritis. Osteoarthritis Cartilage. 2013;21(9):1170–8.CrossRefPubMed
12.
Miranda H, Viikari-Juntura E, Martikainen R, Riihimaki H. A prospective study on knee pain and its risk factors. Osteoarthritis Cartilage. 2002;10(8):623–30.CrossRefPubMed
13.
Martin KR, Kuh D, Harris TB, Guralnik JM, Coggon D, Wills AK. Body mass index, occupational activity, and leisure-time physical activity: an exploration of risk factors and modifiers for knee osteoarthritis in the 1946 British birth cohort. BMC Musculoskelet Disord. 2013;14:219.CrossRefPubMedPubMedCentral
14.
Steinberger J, Moran A, Hong CP, Jacobs Jr DR, Sinaiko AR. Adiposity in childhood predicts obesity and insulin resistance in young adulthood. J Pediatr. 2001;138(4):469–73.CrossRefPubMed
15.
Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med. 1997;337(13):869–73.CrossRefPubMed
16.
Venn AJ, Thomson RJ, Schmidt MD, Cleland VJ, Curry BA, Gennat HC, Dwyer T. Overweight and obesity from childhood to adulthood: a follow-up of participants in the 1985 Australian Schools Health and Fitness Survey. Med J Aust. 2007;186(9):458–60.PubMed
17.
Wills AK, Black S, Cooper R, Coppack RJ, Hardy R, Martin KR, Cooper C, Kuh D. Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study. Ann Rheum Dis. 2012;71(5):655–60.CrossRefPubMed
18.
Sayer AA, Poole J, Cox V, Kuh D, Hardy R, Wadsworth M, Cooper C. Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis. Arthritis Rheum. 2003;48(4):1030–3.CrossRefPubMed
19.
Antoniades L, MacGregor AJ, Andrew T, Spector TD. Association of birth weight with osteoporosis and osteoarthritis in adult twins. Rheumatology (Oxford). 2003;42(6):791–6.CrossRef
20.
Hussain SM, Wang Y, Wluka AE, Shaw JE, Magliano DJ, Graves S, Cicuttini FM. Association of low birth weight and preterm birth with the incidence of knee and hip arthroplasty for osteoarthritis. Arthritis Care Res (Hoboken). 2015;67(4):502–8.CrossRef
21.
Gelber AC, Hochberg MC, Mead LA, Wang NY, Wigley FM, Klag MJ. Body mass index in young men and the risk of subsequent knee and hip osteoarthritis. Am J Med. 1999;107(6):542–8.CrossRefPubMed
22.
Jones G, Ding C, Glisson M, Hynes K, Ma D, Cicuttini F. Knee articular cartilage development in children: a longitudinal study of the effect of sex, growth, body composition, and physical activity. Pediatr Res. 2003;54(2):230–6.CrossRefPubMed
23.
Antony B, Venn A, Cicuttini F, March L, Blizzard L, Dwyer T, Cross M, Jones G, Ding C. Association of body composition and hormonal and inflammatory factors with tibial cartilage volume and sex difference in cartilage volume in young adults. Arthritis Care Res (Hoboken). 2016;68(4):517–25.CrossRef
24.
Taylor ED, Theim KR, Mirch MC, Ghorbani S, Tanofsky-Kraff M, Adler-Wailes DC, Brady S, Reynolds JC, Calis KA, Yanovski JA. Orthopedic complications of overweight in children and adolescents. Pediatrics. 2006;117(6):2167–74.CrossRefPubMedPubMedCentral
25.
Urwin M, Symmons D, Allison T, Brammah T, Busby H, Roxby M, Simmons A, Williams G. Estimating the burden of musculoskeletal disorders in the community: the comparative prevalence of symptoms at different anatomical sites, and the relation to social deprivation. Ann Rheum Dis. 1998;57(11):649–55.CrossRefPubMedPubMedCentral
26.
Paulis WD, Silva S, Koes BW, van Middelkoop M. Overweight and obesity are associated with musculoskeletal complaints as early as childhood: a systematic review. Obes Rev. 2014;15(1):52–67.CrossRefPubMed
27.
Barber Foss KD, Hornsby M, Edwards NM, Myer GD, Hewett TE. Is body composition associated with an increased risk of developing anterior knee pain in adolescent female athletes? Phys Sportsmed. 2012;40(1):13–9.CrossRefPubMedPubMedCentral
28.
Vahasarja V. Prevalence of chronic knee pain in children and adolescents in northern Finland. Acta Paediatr. 1995;84(7):803–5.CrossRefPubMed
29.
Macfarlane GJ, de Silva V, Jones GT. The relationship between body mass index across the life course and knee pain in adulthood: results from the 1958 birth cohort study. Rheumatology (Oxford). 2011;50(12):2251–6.CrossRef
30.
Antony B, Jones G, Venn A, Cicuttini F, March L, Blizzard L, Dwyer T, Cross M, Ding C. Association between childhood overweight measures and adulthood knee pain, stiffness and dysfunction: a 25-year cohort study. Ann Rheum Dis. 2015;74(4):711–7.CrossRefPubMed
31.
Frilander H, Viikari-Juntura E, Heliovaara M, Mutanen P, Mattila VM, Solovieva S. Obesity in early adulthood predicts knee pain and walking difficulties among men: a life course study. Eur J Pain. 2016;20(8):1278–87.CrossRefPubMed
32.
Runhaar J, Koes BW, Clockaerts S, Bierma-Zeinstra SM. A systematic review on changed biomechanics of lower extremities in obese individuals: a possible role in development of osteoarthritis. Obes Rev. 2011;12(12):1071–82.CrossRefPubMed
33.
Cicuttini FM, Baker JR, Spector TD. The association of obesity with osteoarthritis of the hand and knee in women: a twin study. J Rheumatol. 1996;23(7):1221–6.PubMed
34.
Stovitz SD, Pardee PE, Vazquez G, Duval S, Schwimmer JB. Musculoskeletal pain in obese children and adolescents. Acta Paediatr. 2008;97(4):489–93.CrossRefPubMed
35.
Spahn G, Schiele R, Langlotz A, Jung R. Prevalence of functional pain of the back, the hip and the knee in adolescents. Results of a cross-sectional study. Dtsch Med Wochenschr. 2004;129(43):2285–90.CrossRefPubMed
36.
Fairbank JC, Pynsent PB, van Poortvliet JA, Phillips H. Mechanical factors in the incidence of knee pain in adolescents and young adults. J Bone Joint Surg Br. 1984;66(5):685–93.PubMed
37.
Grelsamer R, Moss G, Ee G, Donell S. The patellofemoral syndrome; the same problem as the Loch Ness Monster? Knee. 2009;16(5):301–2.CrossRefPubMed
38.
Molgaard C, Rathleff MS, Simonsen O. Patellofemoral pain syndrome and its association with hip, ankle, and foot function in 16- to 18-year-old high school students: a single-blind case-control study. J Am Podiatr Med Assoc. 2011;101(3):215–22.CrossRefPubMed
39.
Haim A, Yaniv M, Dekel S, Amir H. Patellofemoral pain syndrome: validity of clinical and radiological features. Clin Orthop Relat Res. 2006;451:223–8.CrossRefPubMed
40.
Taunton JE, Ryan MB, Clement DB, McKenzie DC, Lloyd-Smith DR, Zumbo BD. A retrospective case-control analysis of 2002 running injuries. Br J Sports Med. 2002;36(2):95–101.CrossRefPubMedPubMedCentral
41.
Stathopulu E, Baildam E. Anterior knee pain: a long-term follow-up. Rheumatology (Oxford). 2003;42(2):380–2.CrossRef
42.
Sandow MJ, Goodfellow JW. The natural history of anterior knee pain in adolescents. J Bone Joint Surg Br. 1985;67(1):36–8.PubMed
43.
Utting MR, Davies G, Newman JH. Is anterior knee pain a predisposing factor to patellofemoral osteoarthritis? Knee. 2005;12(5):362–5.CrossRefPubMed
44.
Thomas MJ, Wood L, Selfe J, Peat G. Anterior knee pain in younger adults as a precursor to subsequent patellofemoral osteoarthritis: a systematic review. BMC Musculoskelet Disord. 2010;11:201.CrossRefPubMedPubMedCentral
45.
McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage. 2014;22(3):363–88.CrossRefPubMed
46.
Vrezas I, Elsner G, Bolm-Audorff U, Abolmaali N, Seidler A. Case-control study of knee osteoarthritis and lifestyle factors considering their interaction with physical workload. Int Arch Occup Environ Health. 2010;83(3):291–300.CrossRefPubMed
47.
Teichtahl AJ, Wluka AE, Forbes A, Wang Y, English DR, Giles GG, Cicuttini FM. Longitudinal effect of vigorous physical activity on patella cartilage morphology in people without clinical knee disease. Arthritis Rheum. 2009;61(8):1095–102.CrossRefPubMed
48.
Felson DT, Niu J, Clancy M, Sack B, Aliabadi P, Zhang Y. Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: the Framingham Study. Arthritis Rheum. 2007;57(1):6–12.CrossRefPubMed
49.
Gelber AC, Hochberg MC, Mead LA, Wang NY, Wigley FM, Klag MJ. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med. 2000;133(5):321–8.CrossRefPubMed
50.
Andriacchi TP, Mundermann A, Smith RL, Alexander EJ, Dyrby CO, Koo S. A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng. 2004;32(3):447–57.CrossRefPubMed
51.
Julkunen P, Halmesmaki EP, Iivarinen J, Rieppo L, Narhi T, Marjanen J, Rieppo J, Arokoski J, Brama PA, Jurvelin JS, et al. Effects of growth and exercise on composition, structural maturation and appearance of osteoarthritis in articular cartilage of hamsters. J Anat. 2010;217(3):262–74.CrossRefPubMedPubMedCentral
52.
Jones G, Glisson M, Hynes K, Cicuttini F. Sex and site differences in cartilage development: a possible explanation for variations in knee osteoarthritis in later life. Arthritis Rheum. 2000;43(11):2543–9.CrossRefPubMed
53.
Van Ginckel A, Baelde N, Almqvist KF, Roosen P, McNair P, Witvrouw E. Functional adaptation of knee cartilage in asymptomatic female novice runners compared to sedentary controls. A longitudinal analysis using delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC). Osteoarthritis Cartilage. 2010;18(12):1564–9.CrossRefPubMed
54.
Roos EM, Dahlberg L. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum. 2005;52(11):3507–14.CrossRefPubMed
55.
Cotofana S, Ring-Dimitriou S, Hudelmaier M, Himmer M, Wirth W, Sanger AM, Eckstein F. Effects of exercise intervention on knee morphology in middle-aged women: a longitudinal analysis using magnetic resonance imaging. Cells Tissues Organs. 2010;192(1):64–72.CrossRefPubMed
56.
Eckstein F, Faber S, Muhlbauer R, Hohe J, Englmeier KH, Reiser M, Putz R. Functional adaptation of human joints to mechanical stimuli. Osteoarthritis Cartilage. 2002;10(1):44–50.CrossRefPubMed
57.
Antony B, Venn A, Cicuttini F, March L, Blizzard L, Dwyer T, Cross M, Jones G, Ding C. Association of physical activity and physical performance with tibial cartilage volume and bone area in young adults. Arthritis Res Ther. 2015;17:298.CrossRefPubMedPubMedCentral
58.
Waller K, Kujala UM, Kaprio J, Koskenvuo M, Rantanen T. Effect of physical activity on health in twins: a 30-yr longitudinal study. Med Sci Sports Exerc. 2010;42(4):658–64.CrossRefPubMed
59.
El-Metwally A, Salminen JJ, Auvinen A, Kautiainen H, Mikkelsson M. Lower limb pain in a preadolescent population: prognosis and risk factors for chronicity--a prospective 1- and 4-year follow-up study. Pediatrics. 2005;116(3):673–81.CrossRefPubMed
60.
Roemer FW, Jarraya M, Niu J, Silva JR, Frobell R, Guermazi A. Increased risk for radiographic osteoarthritis features in young active athletes: a cross-sectional matched case-control study. Osteoarthritis Cartilage. 2015;23(2):239–43.CrossRefPubMed
61.
Antony B, Jones G, Venn A, Cicuttini F, March L, Blizzard L, Dwyer T, Cross M, Ding C. Childhood physical performance measures and adulthood knee cartilage volume and bone area: a 25-year cohort study. Arthritis Care Res (Hoboken). 2015;67(9):1263–71.CrossRef
62.
Antony B, Venn A, Cicuttini F, March L, Blizzard L, Dwyer T, Halliday A, Cross M, Jones G, Ding C. Correlates of knee bone marrow lesions in younger adults. Arthritis Res Ther. 2016;18(1):31.CrossRefPubMedPubMedCentral
63.
Adams AL, Kessler JI, Deramerian K, Smith N, Black MH, Porter AH, Jacobsen SJ, Koebnick C. Associations between childhood obesity and upper and lower extremity injuries. Inj Prev. 2013;19(3):191–7.CrossRefPubMed
64.
Kessler J, Koebnick C, Smith N, Adams A. Childhood obesity is associated with increased risk of most lower extremity fractures. Clin Orthop Relat Res. 2013;471(4):1199–207.CrossRefPubMed
65.
Tanamas S, Hanna FS, Cicuttini FM, Wluka AE, Berry P, Urquhart DM. Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review. Arthritis Rheum. 2009;61(4):459–67.CrossRefPubMed
66.
Schouten JS, van den Ouweland FA, Valkenburg HA. A 12 year follow up study in the general population on prognostic factors of cartilage loss in osteoarthritis of the knee. Ann Rheum Dis. 1992;51(8):932–7.CrossRefPubMedPubMedCentral
67.
McWilliams DF, Doherty S, Maciewicz RA, Muir KR, Zhang W, Doherty M. Self-reported knee and foot alignments in early adult life and risk of osteoarthritis. Arthritis Care Res (Hoboken). 2010;62(4):489–95.CrossRef
68.
Niu J, Zhang YQ, Torner J, Nevitt M, Lewis CE, Aliabadi P, Sack B, Clancy M, Sharma L, Felson DT. Is obesity a risk factor for progressive radiographic knee osteoarthritis? Arthritis Rheum. 2009;61(3):329–35.CrossRefPubMedPubMedCentral
69.
Felson DT, Goggins J, Niu J, Zhang Y, Hunter DJ. The effect of body weight on progression of knee osteoarthritis is dependent on alignment. Arthritis Rheum. 2004;50(12):3904–9.CrossRefPubMed
70.
Bout-Tabaku S, Shults J, Zemel BS, Leonard MB, Berkowitz RI, Stettler N, Burnham JM. Obesity is associated with greater valgus knee alignment in pubertal children, and higher body mass index is associated with greater variability in knee alignment in girls. J Rheumatol. 2015;42(1):126–33.CrossRefPubMed
71.
Brennan SL, Lane SE, Lorimer M, Buchbinder R, Wluka AE, Page RS, Osborne RH, Pasco JA, Sanders KM, Cashman K, et al. Associations between socioeconomic status and primary total knee joint replacements performed for osteoarthritis across Australia 2003–10: data from the Australian Orthopaedic Association National Joint Replacement Registry. BMC Musculoskelet Disord. 2014;15:356.CrossRefPubMedPubMedCentral
72.
Macfarlane GJ, Norrie G, Atherton K, Power C, Jones GT. The influence of socioeconomic status on the reporting of regional and widespread musculoskeletal pain: results from the 1958 British Birth Cohort Study. Ann Rheum Dis. 2009;68(10):1591–5.CrossRefPubMed
73.
Baldassari AR, Cleveland RJ, Callahan LF. Independent associations of childhood and current socioeconomic status with risk of self-reported doctor-diagnosed arthritis in a family-medicine cohort of North-Carolinians. BMC Musculoskelet Disord. 2013;14:327.CrossRefPubMedPubMedCentral
74.
Springer KW, Sheridan J, Kuo D, Carnes M. Long-term physical and mental health consequences of childhood physical abuse: results from a large population-based sample of men and women. Child Abuse Negl. 2007;31(5):517–30.CrossRefPubMedPubMedCentral
75.
Goodwin RD, Stein MB. Association between childhood trauma and physical disorders among adults in the United States. Psychol Med. 2004;34(3):509–20.CrossRefPubMed
76.
Stein MB, Barrett-Connor E. Sexual assault and physical health: findings from a population-based study of older adults. Psychosom Med. 2000;62(6):838–43.CrossRefPubMed
77.
Fuller-Thomson E, Stefanyk M, Brennenstuhl S. The robust association between childhood physical abuse and osteoarthritis in adulthood: findings from a representative community sample. Arthritis Rheum. 2009;61(11):1554–62.CrossRefPubMed
Metadata
Title
Do early life factors affect the development of knee osteoarthritis in later life: a narrative review
Authors
Benny Antony
Graeme Jones
Xingzhong Jin
Changhai Ding
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2016
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/s13075-016-1104-0

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