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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2019 | Distal Radius Fracture | Research article

Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial

Authors: Chunhua Zhang, Sujuan Xue, Yong Wang, Dan Yu, Limei Hua, Chunhua Guo, Dawei Wang, Min Lei

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2019

Abstract

Background

To evaluate the effect of oral Lactobacillus casei Shirota (LcS) administration on recovery of hand functions in senior patients diagnosed with an acute distal radius fracture.

Methods

This clinical trial is double-blind and placebo-controlled, in which 293 senior patients with distal radius fracture were initially enrolled. After exclusion, 264 eligible patients were randomly assigned to receive oral placebo or LcS daily for a period of 3 months after the fracture. Treatment outcomes were Michigan Hand Questionnaire (MHQ) score, radial deviation and inclination, and ulnar deviation and variance, all of which were monitored and measured every month.

Results

Throughout the length of this study, MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo, over the 3-month intervention period.

Conclusion

Oral administration of LcS dramatically accelerated hand function recovery in senior patients with distal radius fracture.

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Title: Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial
Authors: Chunhua Zhang
Sujuan Xue
Yong Wang
Dan Yu
Limei Hua
Chunhua Guo
Dawei Wang
Min Lei
Publication date: 01-12-2019
Publisher: BioMed Central
Keyword: Distal Radius Fracture
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2019
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-019-1310-y

At a glance: The STEP trials

Springer Medicine

Oral administration of Lactobacillus casei Shirota improves recovery of hand functions after distal radius fracture among elder patients: a placebo-controlled, double-blind, and randomized trial

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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