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Open Access 01-12-2011 | Article

Dissection of genetic associations with language-related traits in population-based cohorts

Author: Silvia Paracchini

Published in: Journal of Neurodevelopmental Disorders | Issue 4/2011

Abstract

Recent advances in the field of language-related disorders have led to the identification of candidate genes for specific language impairment (SLI) and dyslexia. Replication studies have been conducted in independent samples including population-based cohorts, which can be characterised for a large number of relevant cognitive measures. The availability of a wide range of phenotypes allows us to not only identify the most suitable traits for replication of genetic association but also to refine the associated cognitive trait. In addition, it is possible to test for pleiotropic effects across multiple phenotypes which could explain the extensive comorbidity observed across SLI, dyslexia and other neurodevelopmental disorders. The availability of genome-wide genotype data for such cohorts will facilitate this kind of analysis but important issues, such as multiple test corrections, have to be taken into account considering that small effect sizes are expected to underlie such associations.

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Title: Dissection of genetic associations with language-related traits in population-based cohorts
Author: Silvia Paracchini
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Journal of Neurodevelopmental Disorders / Issue 4/2011
Print ISSN: 1866-1947
Electronic ISSN: 1866-1955
DOI: https://doi.org/10.1007/s11689-011-9091-6

2024 ASCO Annual Meeting

Springer Medicine

Dissection of genetic associations with language-related traits in population-based cohorts

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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