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Open Access 01-12-2020 | Diseases of the neuromuscular synapses and muscles | Research Letter

Urine TITIN N-fragment as a novel biomarker for critical illness myopathy: a pilot study

Authors: Hidehiko Nakano, Tsunehiro Matsubara, Kazuma Yamakawa, Kensuke Nakamura

Published in: Critical Care | Issue 1/2020

Excerpt

Intensive care unit (ICU)-acquired weakness is a muscular weakness without other cause after intensive care and consisting of critical illness polyneuropathy and critical illness myopathy (CIM) [1]. Muscle atrophy can occur quite early during critical illness because of increased muscle protein breakdown (MPB) and decreased muscle protein synthesis (MPS) [1]. Although muscle mass can be evaluated using ultrasound [2] and computed tomography (CT) [3], MPS and MPB are difficult to evaluate separately. Muscle biopsy can directly evaluate MPB in CIM directly [4], but it is invasive. Creatine kinase cannot evaluate MPB in CIM [1]. Therefore, no noninvasive technique has been established. …

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Title: Urine TITIN N-fragment as a novel biomarker for critical illness myopathy: a pilot study
Authors: Hidehiko Nakano
Tsunehiro Matsubara
Kazuma Yamakawa
Kensuke Nakamura
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Diseases of the neuromuscular synapses and muscles
Myopathy
Biomarkers
Published in: Critical Care / Issue 1/2020
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-020-02842-5

At a glance: The STEP trials

Springer Medicine

Urine TITIN N-fragment as a novel biomarker for critical illness myopathy: a pilot study

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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