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Journal of Cardiovascular Magnetic Resonance
Published in: Journal of Cardiovascular Magnetic Resonance 1/2020

Open Access 01-12-2020 | Research

Direct measurement of atrioventricular valve regurgitant jets using 4D flow cardiovascular magnetic resonance is accurate and reliable for children with congenital heart disease: a retrospective cohort study

Authors: Kimberley Jacobs, Joseph Rigdon, Frandics Chan, Joseph Y. Cheng, Marcus T. Alley, Shreyas Vasanawala, Shiraz A. Maskatia

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2020

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Abstract

Background

3D-time resolved flow (4DF) cardiovascular magnetic resonance (CMR) with retrospective analysis of atrioventricular valve regurgitation (AVVR) allows for internal validation by multiple direct and indirect methods. Limited data exist on direct measurement of AVVR by 4DF CMR in pediatric congenital heart disease (CHD). We aimed to validate direct measurement of the AVVR jet as accurate and reliable compared to the volumetric method (clinical standard by 2D CMR) and as a superior method of internal validation than the annular inflow method.

Methods

We identified 44 consecutive patients with diverse CHD referred for evaluation of AVVR by CMR. 1.5 T or 3 T scanners, intravenous contrast, and a combination of parallel imaging and compressed sensing were used. Four methods of measuring AVVR volume (RVol) were used: volumetric method (VOL; the clinical standard) = stroke volume by 2D balanced steady-state free precession – semilunar valve forward flow (SLFF); annular inflow method (AIM) = atrioventricular valve forward flow [AVFF] – semilunar valve net flow (SLNF); and direct measurement (JET). AVFF was measured using static and retrospective valve tracking planes. SLFF, SLNF, AVFF, and JET were measured by 4DF phase contrast. Regurgitant fraction was calculated as [RVol/(RVol+SLNF)]× 100. Statistical methods included Spearman, Wilcoxon rank sum test/Student paired t-test, Bland Altman analysis, and intra-class coefficient (ICC), where appropriate.

Results

Regurgitant fraction by JET strongly correlated with the indirect methods (VOL and AIM) (ρ = 0.73–0.80, p < 0.001) and was similar to VOL with a median difference (interquartile range) of − 1.5% (− 8.3–7.2%; p = 0.624). VOL had weaker correlations with AIM and JET (ρ = 0.69–0.73, p < 0.001). AIM underestimated RF by 3.6–6.9% compared to VOL and JET, p < 0.03. Intra- and inter- observer reliability were excellent for all methods (ICC 0.94–0.99). The mean (±standard deviation) inter-observer difference for VOL was 2.4% (±5.1%), p < 0.05.

Conclusions

In a diverse cohort of pediatric CHD, measurement of AVVR using JET is accurate and reliable to VOL and is a superior method of internal validation compared to AIM. This study supports use of 4DF CMR for measurement of AVVR, obviating need for expert prospective prescription during image acquisition by 2D CMR.
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Metadata
Title
Direct measurement of atrioventricular valve regurgitant jets using 4D flow cardiovascular magnetic resonance is accurate and reliable for children with congenital heart disease: a retrospective cohort study
Authors
Kimberley Jacobs
Joseph Rigdon
Frandics Chan
Joseph Y. Cheng
Marcus T. Alley
Shreyas Vasanawala
Shiraz A. Maskatia
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Journal of Cardiovascular Magnetic Resonance / Issue 1/2020
Electronic ISSN: 1532-429X
DOI
https://doi.org/10.1186/s12968-020-00612-4

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