Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
European Radiology
Published in: European Radiology 5/2019

01-05-2019 | Musculoskeletal

Diffusion tensor imaging of articular cartilage using a navigated radial imaging spin-echo diffusion (RAISED) sequence

Authors: Alejandra Duarte, Amparo Ruiz, Uran Ferizi, Jenny Bencardino, Steven B. Abramson, Jonathan Samuels, Svetlana Krasnokutsky-Samuels, José G. Raya

Published in: European Radiology | Issue 5/2019

Login to get access

Abstract

Objective

To validate a radial imaging spin-echo diffusion tensor (RAISED) sequence for high-resolution diffusion tensor imaging (DTI) of articular cartilage at 3 T.

Methods

The RAISED sequence implementation is described, including the used non-linear motion correction algorithm. The robustness to eddy currents was tested on phantoms, and accuracy of measurement was assessed with measurements of temperature-dependent diffusion of free water. Motion correction was validated by comparing RAISED with single-shot diffusion-weighted echo-planar imaging (EPI) measures. DTI was acquired in asymptomatic subjects (n = 6) and subjects with doubtful (Kellgren-Lawrence [KL] grade 1, n = 9) and mild (KL = 2, n = 9) symptomatic knee osteoarthritis (OA). MD and FA values without correction, and after all corrections, were calculated. A test-retest evaluation of the DTI acquisition on three asymptomatic and three OA subjects was also performed.

Results

The root mean squared coefficient of variation of the global test-restest reproducibility was 3.54% for MD and 5.34% for FA. MD was significantly increased in both femoral condyles (7–9%) of KL 1 and in the medial (11–17%) and lateral (10–12%) compartments of KL 2 subjects. Averaged FA presented a trend of lower values with increasing KL grade, which was significant for the medial femoral condyle (-11%) of KL 1 and all three compartments in KL 2 subjects (-18 to -11%). Group differences in MD and FA were only significant after motion correction.

Conclusion

The RAISED sequence with the proposed reconstruction framework provides reproducible assessment of DTI parameters in vivo at 3 T and potentially the early stages of the disease in large regions of interest.

Key Points

• DTI of articular cartilage is feasible at 3T with a multi-shot RAISED sequence with non-linear motion correction.
• RAISED sequence allows estimation of the diffusion indices MD and FA with test-retest errors below 4% (MD) and 6% (FA).
• RAISED-based measurement of DTI of articular cartilage with non-linear motion correction holds potential to differentiate healthy from OA subjects.
Literature
1.
Filidoro L, Dietrich O, Weber J et al (2005) High-resolution diffusion tensor imaging of human patellar cartilage: feasibility and preliminary findings. Magn Reson Med 53:993–998CrossRefPubMed
2.
Meder R, de Visser SK, Bowden JC, Bostrom T, Pope JM (2006) Diffusion tensor imaging of articular cartilage as a measure of tissue microstructure. Osteoarthritis Cartilage 14:875–881CrossRefPubMed
3.
de Visser SK, Bowden JC, Wentrup-Byrne E et al (2008) Anisotropy of collagen fibre alignment in bovine cartilage: comparison of polarised light microscopy and spatially resolved diffusion-tensor measurements. Osteoarthritis Cartilage 16:689–697CrossRefPubMed
4.
Raya JG, Melkus G, Adam-Neumair S et al (2011) Change of diffusion tensor imaging parameters in articular cartilage with progressive proteoglycan extraction. Invest Radiol 46:401–409CrossRefPubMed
5.
Raya JG, Melkus G, Adam-Neumair S et al (2013) Diffusion-tensor imaging of human articular cartilage specimens with early signs of cartilage damage. Radiology 266:831–841CrossRefPubMed
6.
Deng X, Farley M, Nieminen MT, Gray M, Burstein D (2007) Diffusion tensor imaging of native and degenerated human articular cartilage. Magn Reson Imaging 25:168–171CrossRefPubMed
7.
Ferizi U, Rossi I, Lee Y et al (2017) Diffusion tensor imaging of articular cartilage at 3T correlates with histology and biomechanics in a mechanical injury model. Magn Reson Med 78:69–78CrossRefPubMed
8.
Guha A, Wyatt C, Karampinos DC, Nardo L, Link TM, Majumdar S (2015) Spatial variations in magnetic resonance-based diffusion of articular cartilage in knee osteoarthritis. Magn Reson Imaging 33:1051–1058CrossRefPubMedPubMedCentral
9.
Raya JG, Dettmann E, Notohamiprodjo M, Krasnokutsky S, Abramson S, Glaser C (2014) Feasibility of in vivo diffusion tensor imaging of articular cartilage with coverage of all cartilage regions. Eur Radiol 24(7):1700–1706CrossRefPubMed
10.
Raya JG, Horng A, Dietrich O et al (2012) Articular cartilage: in vivo diffusion-tensor imaging. Radiology 262:550–559CrossRefPubMed
11.
Berstein MA, King KF, Zhou XJ (2004) Chapter 14 − Basic pulse sequences. In: Berstein MA, King KF, Zhou XJ (eds) Handbook of MRI pulse sequences, 1st edition
12.
Miller KL, Pauly JM (2003) Nonlinear phase correction for navigated diffusion imaging. Magn Reson Med 50:343–353CrossRefPubMed
13.
Skare S, Hedehus M, Moseley ME, Li TQ (2000) Condition number as a measure of noise performance of diffusion tensor data acquisition schemes with MRI. J Magn Reson 147:340–352CrossRefPubMed
14.
Mills R (1973) Self-diffusion in normal and heavy water. J Phys Chem 77:685–688CrossRef
15.
Tofts PS, Lloyd D, Clark CA et al (2000) Test liquids for quantitative MRI measurements of self-diffusion coefficients in vivo. Magn Reson Med 43:368–374CrossRefPubMed
16.
Gillen KT, Douglass DC, Hoch MJR (1972) Self-diffusion in liquid water to -31°C. J Chem Phys 57:5117–5119CrossRef
17.
Harris KR, Woolf LA (1980) Pressure and temperature dependence of the self diffusion coefficient of water and oxygen-18 water. J Chem Soc Faraday Trans 76:377–385CrossRef
18.
19.
Bodammer N, Kaufmann J, Kanowski M, Tempelmann C (2004) Eddy current correction in diffusion-weighted imaging using pairs of images acquired with opposite diffusion gradient polarity. Magn Reson Med 51:188–193CrossRefPubMed
20.
Neeman M, Freyer JP, Sillerud LO (1991) A simple method for obtaining cross-term-free images for diffusion anisotropy studies in NMR microimaging. Magn Reson Med 21:138–143CrossRefPubMed
21.
König L, Groher M, Keil A, Glaser C, Reiser M, Navab N (2007) Semi-automatic segmentation of the patellar cartilage in MRI. Bildverarbeitung für die Medizin 17:404–408
22.
Altman R, Asch E, Bloch D et al (1986) Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum 29:1039–1049CrossRef
23.
24.
Guizar-Sicairos M, Thurman ST, Fienup JR (2008) Efficient subpixel image registration algorithms. Opt Lett 33:156–158CrossRefPubMed
25.
Ferizi U, Ruiz A, Rossi I, Bencardino J, Raya JG (2018) A robust diffusion tensor model for clinical applications of MRI to cartilage. Magn Reson Med 79:1157–1164CrossRefPubMed
26.
27.
Lin LI (1989) A concordance correlation coefficient to evaluate reproducibility. Biometrics 45:255–268CrossRef
28.
Miller KL, Hargreaves BA, Gold GE, Pauly JM (2004) Steady-state diffusion-weighted imaging of in vivo knee cartilage. Magn Reson Med 5:394–398CrossRef
29.
Bieri O, Ganter C, Scheffler K (2012) Quantitative in vivo diffusion imaging of cartilage using double echo steady-state free precession. Magn Reson Med 68:720–729CrossRefPubMed
30.
31.
Staroswiecki E, Granlund KL, Alley MT, Gold GE, Hargreaves BA (2012) Simultaneous estimation of T(2) and apparent diffusion coefficient in human articular cartilage in vivo with a modified three-dimensional double echo steady state (DESS) sequence at 3 T. Magn Reson Med 67:1086–1096CrossRefPubMed
32.
33.
Azuma T, Nakai R, Takizawa O, Tsutsumi S (2009) In vivo structural analysis of articular cartilage using diffusion tensor magnetic resonance imaging. Magn Reson Imaging 27:1242–1248CrossRefPubMed
34.
Glaser C, Mendlik T, Dinges J et al (2006) Global and regional reproducibility of T2 relaxation time measurements in human patellar cartilage. Magn Reson Med 56:527–534CrossRefPubMed
35.
Raya JG, Horng A, Dietrich O et al (2009) Voxel-based reproducibility of T2 relaxation time in patellar cartilage at 1.5 T with a new validated 3D rigid registration algorithm. MAGMA 22:229–239
36.
Madelin G, Babb JS, Xia D, Chang G, Jerschow A, Regatte RR (2012) Reproducibility and repeatability of quantitative sodium magnetic resonance imaging in vivo in articular cartilage at 3 T and 7 T. Magn Reson Med 68:841–849CrossRef
37.
Multanen J, Rauvala E, Lammentausta E et al (2009) Reproducibility of imaging human knee cartilage by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5 Tesla. Osteoarthritis Cartilage 17:559–564CrossRefPubMed
38.
Jordan CD, McWalter EJ, Monu UD et al (2014) Variability of CubeQuant T1rho, quantitative DESS T2, and cones sodium MRI in knee cartilage. Osteoarthritis Cartilage 22:1559–1567CrossRefPubMedPubMedCentral
39.
Gupta R, Virayavanich W, Kuo D et al (2014) MR T(1)rho quantification of cartilage focal lesions in acutely injured knees: correlation with arthroscopic evaluation. Magn Reson Imaging 32:1290–1296CrossRefPubMedPubMedCentral
40.
Xu J, Xie G, Di Y, Bai M, Zhao X (2011) Value of T2-mapping and DWI in the diagnosis of early knee cartilage injury. J Radiol Case Rep 5:13–18PubMedPubMedCentral
Metadata
Title
Diffusion tensor imaging of articular cartilage using a navigated radial imaging spin-echo diffusion (RAISED) sequence
Authors
Alejandra Duarte
Amparo Ruiz
Uran Ferizi
Jenny Bencardino
Steven B. Abramson
Jonathan Samuels
Svetlana Krasnokutsky-Samuels
José G. Raya
Publication date
01-05-2019
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-018-5780-9

Other articles of this Issue 5/2019

European Radiology 5/2019 Go to the issue

Gastrointestinal

Patients’ experience of screening CT colonography with reduced and full bowel preparation in a randomised trial

Hepatobiliary-Pancreas

Multidetector CT findings differ between surgical grades of pancreatic fistula after pancreaticoduodenectomy

Magnetic Resonance

Evaluation of renal dysfunction using texture analysis based on DWI, BOLD, and susceptibility-weighted imaging

Gastrointestinal

The roles of CT and EUS in the preoperative evaluation of gastric gastrointestinal stromal tumors larger than 2 cm

Computed Tomography

Development of a radiomics nomogram based on the 2D and 3D CT features to predict the survival of non-small cell lung cancer patients

Breast

Evaluation of pressure-controlled mammography compression paddles with respect to force-controlled compression paddles in clinical practice