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Immunity & Ageing
Published in: Immunity & Ageing 1/2011

Open Access 01-12-2011 | Research

Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets

Authors: Nicolle HR Litjens, Elly A de Wit, Michiel GH Betjes

Published in: Immunity & Ageing | Issue 1/2011

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Abstract

The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n = 139) and age-matched healthy individuals. The results show that CMV-seropositivity is associated with expansion of both CD4+ and CD8+ memory T cells which is already observed in young healthy individuals. In addition, CMV-seropositive healthy individuals have a more differentiated memory T cell profile. Only CMV-seropositive healthy individuals showed an age-dependent decrease in CD4+ naïve T cells. The age-related decrease in the number of CD8+ naïve T cells was CMV-independent. In contrast, all ESRD patients showed a profound naïve T-cell lymphopenia at every decade. CMV-seropositivity aggravated the contraction of CD4+ naïve T cells and increased the number of differentiated CD4+ and CD8+ memory T cells. In conclusion, CMV-seropositivity markedly alters the homeostasis of circulating T cells in healthy individuals and aggravates the T cell dysregulation observed in ESRD patients.
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Metadata
Title
Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets
Authors
Nicolle HR Litjens
Elly A de Wit
Michiel GH Betjes
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Immunity & Ageing / Issue 1/2011
Electronic ISSN: 1742-4933
DOI
https://doi.org/10.1186/1742-4933-8-2

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