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European Journal of Nuclear Medicine and Molecular Imaging

Published in:

01-03-2016 | Original Article

Different loss of dopamine transporter according to subtype of multiple system atrophy

Authors: Hae Won Kim, Jae Seung Kim, Minyoung Oh, Jungsu S. Oh, Sang Joo Lee, Seung Jun Oh, Sun Ju Chung, Chong Sik Lee

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 3/2016

Abstract

Purpose

The aim of this study was to evaluate whether striatal dopamine transporter (DAT) loss as measured by ¹⁸F-fluorinated-N-3-fluoropropyl-2-b-carboxymethoxy-3-b-(4-iodophenyl) nortropane ([¹⁸F]FP-CIT) PET differs according to the metabolic subtype of multiple system atrophy (MSA) as assessed by [¹⁸F]FDG PET.

Methods

This retrospective study included 50 patients with clinically diagnosed MSA who underwent [¹⁸F]FP-CIT and [¹⁸F]FDG brain PET scans. The PET images were analysed using 12 striatal subregional volume-of-interest templates (bilateral ventral striatum, anterior caudate, posterior caudate, anterior putamen, posterior putamen, and ventral putamen). The patients were classified into three metabolic subtypes according to the [¹⁸F]FDG PET findings: MSA-P_m (striatal hypometabolism only), MSA-mixed_m (both striatal and cerebellar hypometabolism), and MSA-C_m (cerebellar hypometabolism only). The subregional glucose metabolic ratio (MR_gluc), subregional DAT binding ratio (BR_DAT), and intersubregional ratio (ISR_DAT; defined as the BR_DAT ratio of one striatal subregion to that of another striatal subregion) were compared according to metabolic subtype.

Results

Of the 50 patients, 13 presented with MSA-P_m, 16 presented with MSA-mixed_m, and 21 presented with MSA-C_m. The BR_DAT of all striatal subregions in the MSA-P_m and MSA-mixed_m groups were significantly lower than those in the MSA-C_m group. The posterior putamen/anterior putamen ISR_DAT and anterior putamen/ventral striatum ISR_DAT in the MSA-P_m and MSA-mixed_m groups were significantly lower than those in the MSA-C_m group.

Conclusion

Patients with MSA-P_m and MSA-mixed_m showed more severe DAT loss in the striatum than patients with MSA-C_m. Patients with MSA-C_m had more diffuse DAT loss than patients with MSA-P_m and MSA-mixed_m.

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Title: Different loss of dopamine transporter according to subtype of multiple system atrophy
Authors: Hae Won Kim
Jae Seung Kim
Minyoung Oh
Jungsu S. Oh
Sang Joo Lee
Seung Jun Oh
Sun Ju Chung
Chong Sik Lee
Publication date: 01-03-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 3/2016
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-015-3191-6

At a glance: The STEP trials

Springer Medicine

Different loss of dopamine transporter according to subtype of multiple system atrophy

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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