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Thrombosis Journal
Published in: Thrombosis Journal 1/2016

Open Access 01-10-2016 | Review

Different impact of factor VIII products on inhibitor development?

Author: H. Marijke van den Berg

Published in: Thrombosis Journal | Special Issue 1/2016

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Abstract

Inhibitors are the most serious side effect of haemophilia treatment; they occur in 25–30 % of all patients with severe haemophilia A. Over the last 2 decades, conflicting data on the impact of clotting products have been published.
Due to small studies of selected cases, appreciation of the impact of any particular product has been difficult. Moreover, the emphasis on inhibitor testing has led to increased detection of low-titre inhibitors (to >10 %), while the percentage of high-titre inhibitors is still around 20 %.
Other non-genetic risk factors, such as dosing and intensive treatment, are able to increase individual inhibitor risk. Early prophylaxis might reduce inhibitor risk. Well-defined large PUP studies including products should be considered. This can only be achieved in collaboration with all stakeholders.
In conclusion, while the impact of FVIII products on inhibitor development is large, presently the actual impact of any specific product is unclear.
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Metadata
Title
Different impact of factor VIII products on inhibitor development?
Author
H. Marijke van den Berg
Publication date
01-10-2016
Publisher
BioMed Central
Published in
Thrombosis Journal / Issue Special Issue 1/2016
Electronic ISSN: 1477-9560
DOI
https://doi.org/10.1186/s12959-016-0102-4

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