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Journal of Orthopaedic Science

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Open Access 01-01-2013 | Original Article

Different analgesic effects of adenosine between postoperative and neuropathic pain

Authors: Gotaro Yamaoka, Hideki Horiuchi, Tadao Morino, Hiromasa Miura, Tadanori Ogata

Published in: Journal of Orthopaedic Science | Issue 1/2013

Abstract

Background

Adenosine is an endogenous neuromodulator in both the peripheral and central nervous systems. Adenosine inhibits pain signals by hyperpolarizing neuronal membrane.

Methods

To clarify the effects of adenosine on pain signals, we tested intrathecal adenosine injection in two neuropathic pains (spinal cord compression and chronic constriction of sciatic nerve) and postoperative pain (plantar incision).

Results

In all three kinds of pain models, significant shortening of withdrawal latencies to thermal stimulation were detected from 24 h to 1 week after the surgery. Significant improvements of pain sensation were observed in all three models after intrathecal injection of Cl-adenosine 24 h after surgery. At 72 h after surgery, intrathecal Cl-adenosine injection inhibited hyperalgesia in the two neuropathic pain models but not in the postoperative pain model. Adenosine A1R messenger RNA (mRNA) expression significantly decreased in the plantar incision model. Adenosine A1R protein levels also decreased compared with the other two models and normal control.

Conclusions

These results suggest that adenosine effectively inhibits pain signals in neuropathic pain but is less effective in postoperative pain because of the decrease in adenosine A1 receptors.

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Title: Different analgesic effects of adenosine between postoperative and neuropathic pain
Authors: Gotaro Yamaoka
Hideki Horiuchi
Tadao Morino
Hiromasa Miura
Tadanori Ogata
Publication date: 01-01-2013
Publisher: Springer Japan
Published in: Journal of Orthopaedic Science / Issue 1/2013
Print ISSN: 0949-2658
Electronic ISSN: 1436-2023
DOI: https://doi.org/10.1007/s00776-012-0302-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Different analgesic effects of adenosine between postoperative and neuropathic pain

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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