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Osteoporosis International

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01-06-2007 | Original Article

Differences of bone mass and bone structure in osteopenic rat models caused by spinal cord injury and ovariectomy

Authors: S.-D. Jiang, C. Shen, L.-S. Jiang, L.-Y. Dai

Published in: Osteoporosis International | Issue 6/2007

Abstract

Summary

Both spinal cord injury and ovariectomy can result in ostepenia in rats. SCI induces more deterioration of cortical geometric structure and trabecular microstructure in the proximal tibial metaphysis than OVX. The proximal tibial metaphysis microstructure significantly correlates with its biomechanical properties.

Introduction

The purpose of the present study was to compare the effects of spinal cord injury (SCI) and ovariectomy (OVX) on bone gain in young female rats.

Methods

Thirty young female Sprague-Dawley rats were randomized into three groups: age-matched intact control (CON), OVX and SCI. The tibiae were assessed for DXA and micro-CT analysis, biomechanical testing, the upper tibial epiphyseal plate height, and blood samples for biochemical analysis.

Results

SCI rats showed lower aBMD in the proximal tibiae as compared with OVX rats. Cortical geometric structural parameters of the tibial midshaft in SCI rats were significantly lower than OVX rats. SCI or OVX induced significant changes in all trabecular microstructural parameters in the proximal tibial metaphysis. The trabecular separation (Tb.Sp) and structure mode index (SMI) in SCI rats were significantly higher than in OVX rats. BV/TV explained 84% of the variation of ultimate load of the proximal tibial metaphysis. There was no difference of the upper tibial epiphyseal plate height between SCI and OVX rats. Serum NTX level in SCI rats was significantly higher than in OVX rats.

Conclusions

SCI induces more deterioration of cortical bone geometric structure and trabecular microstructure in the proximal tibial metaphysis than OVX.

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Title: Differences of bone mass and bone structure in osteopenic rat models caused by spinal cord injury and ovariectomy
Authors: S.-D. Jiang
C. Shen
L.-S. Jiang
L.-Y. Dai
Publication date: 01-06-2007
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 6/2007
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-006-0299-3

At a glance: The STEP trials

Springer Medicine

Differences of bone mass and bone structure in osteopenic rat models caused by spinal cord injury and ovariectomy

Abstract

Summary

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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