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01-06-2007 | Original Article

Genetic markers for ancestry are correlated with body composition traits in older African Americans

Authors: J. R. Shaffer, C. M. Kammerer, D. Reich, G. McDonald, N. Patterson, B. Goodpaster, D. C. Bauer, J. Li, A. B. Newman, J. A. Cauley, T. B. Harris, F. Tylavsky, R. E Ferrell, J. M. Zmuda, for the Health ABC study

Published in: Osteoporosis International | Issue 6/2007

Abstract

Summary

Individual-specific percent European ancestry was assessed in 1,277 African Americans. We found significant correlations between proportion of European ancestry and several musculoskeletal traits, indicating that admixture mapping may be a useful strategy for locating genes affecting these traits.

Introduction

Genotype data for admixed populations can be used to detect chromosomal regions influencing disease risk if allele frequencies at disease-related loci differ between parental populations. We assessed evidence for differentially distributed alleles affecting bone and body composition traits in African Americans.

Methods

Bone mineral density (BMD) and body composition data were collected for 1,277 African and 1,790 European Americans (aged 70–79). Maximum likelihood methods were used to estimate individual-specific percent European ancestry for African Americans genotyped at 37 ancestry-informative genetic markers. Partial correlations between body composition traits and percent European ancestry were calculated while simultaneously adjusting for the effects of covariates.

Results

Percent European ancestry (median = 18.7%) in African Americans was correlated with femoral neck BMD in women (r = −0.18, p < 10⁻⁵) and trabecular spine BMD in both sexes (r = −0.18, p < 10⁻⁵) independently of body size, fat, lean mass, and other covariates. Significant associations of European ancestry with appendicular lean mass (r = −0.19, p < 10⁻¹⁰), total lean mass (r = −0.12, p < 10⁻⁴), and total body fat (r = 0.09, p < 0.002) were also observed for both sexes.

Conclusions

These results indicate that some population differences in body composition may be due to population-specific allele frequencies, suggesting the utility of admixture mapping for identifying susceptibility genes for osteoporosis, sarcopenia, and obesity.

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Title: Genetic markers for ancestry are correlated with body composition traits in older African Americans
Authors: J. R. Shaffer
C. M. Kammerer
D. Reich
G. McDonald
N. Patterson
B. Goodpaster
D. C. Bauer
J. Li
A. B. Newman
J. A. Cauley
T. B. Harris
F. Tylavsky
R. E Ferrell
J. M. Zmuda
for the Health ABC study
Publication date: 01-06-2007
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 6/2007
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-006-0316-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Genetic markers for ancestry are correlated with body composition traits in older African Americans

Abstract

Summary

Introduction

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusions

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