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Cancer Causes & Control
Published in: Cancer Causes & Control 3/2011

Open Access 01-03-2011 | Original paper

Dietary intake of micronutrients and the risk of developing bladder cancer: results from the Belgian case–control study on bladder cancer risk

Authors: Maree T. Brinkman, Frank Buntinx, Eliane Kellen, Pieter C. Dagnelie, Martien C. J. M. Van Dongen, Erik Muls, Maurice P. Zeegers

Published in: Cancer Causes & Control | Issue 3/2011

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Abstract

Objective

We aimed to investigate the effect of dietary intake of micronutrients that are metabolized and excreted via the urinary tract on bladder cancer risk.

Methods

A semi-quantitative 322 item food frequency questionnaire (FFQ) was used to collect dietary data from 200 bladder cancer cases and 386 control subjects participating in the Belgian case–control study on bladder cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using unconditional logistic regression adjusting for age, sex, smoking characteristics, occupational exposures, and energy intake.

Results

We observed a positive association between calcium intake and bladder cancer (OR: 1.77; 95% CI: 1.00–3.15; p-trend = 0.049) and increased odds, although not statistically significant, for highest tertile of phosphorus intake (OR: 1.82; 95% CI: 0.95–3.49; p-trend = 0.06). We identified possible modification of the effects of both calcium and phosphorus by level of magnesium intake. Increased odds of bladder cancer were also observed for participants with highest intake of phosphorus and lowest intake of vitamin D (OR: 4.25; 95% CI: 1.44–12.55) and among older participants with the highest intakes of calcium (OR: 1.90; 95% CI: 1.08–3.36) and phosphorus (OR: 2.02; 95% CI: 1.05–3.92).

Conclusion

The positive associations we observed between bladder cancer and intake of calcium and phosphorus require confirmation by other studies. The balances between inter-related micronutrients also warrant further examination.
Literature
1.
Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108CrossRefPubMed
2.
Steinmaus CM, Nunez S, Smith AH (2000) Diet and bladder cancer: a meta-analysis of six dietary variables. Am J Epidemiol 151:693–702PubMed
3.
Brinkman M, Buntinx F, Muls E, Zeegers MP (2006) Use of selenium in chemoprevention of bladder cancer. Lancet Oncol 7:766–774CrossRefPubMed
4.
Cohen SM (1995) Role of urinary physiology and chemistry in bladder carcinogenesis. Food Chem Toxicol 33:715–730CrossRefPubMed
5.
Vena JE, Graham S, Freudenheim J et al (1992) Diet in the epidemiology of bladder cancer in western New York. Nutr Cancer 18:255–264CrossRefPubMed
6.
Michaud DS, Spiegelman D, Clinton SK, Rimm EB, Willett WC, Giovannucci E (2000) Prospective study of dietary supplements, macronutrients, micronutrients, and risk of bladder cancer in US men. Am J Epidemiol 152:1145–1153CrossRefPubMed
7.
Brinkman MT, Karagas MR, Zens MS, Schned A, Reulen RC, Zeegers MP (2010) Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study. Cancer Causes Control 21:609–619CrossRefPubMed
8.
Byrd-Bredbenner C, Moe G, Beshgetoor D, Berning J (2009) Wardlaw’s perspectives in nutrition, 8th edn. McGraw-Hill, New York
9.
Riboli E, Gonzalez CA, Lopez-Abente G et al (1991) Diet and bladder cancer in Spain: a multi-centre case–control study. Int J Cancer 49:214–219CrossRefPubMed
10.
Keszei AP, Schouten LJ, Goldbohm RA, van den Brandt PA (2010) Dairy intake and the risk of bladder cancer in the Netherlands Cohort Study on Diet and Cancer. Am J Epidemiol 171:436–446CrossRefPubMed
11.
Folsom AR, Hong CP (2006) Magnesium intake and reduced risk of colon cancer in a prospective study of women. Am J Epidemiol 163:232–235CrossRefPubMed
12.
Tukiendorf A, Rybak Z (2004) New data on ecological analysis of possible relationship between magnesium in drinking water and liver cancer. Magnes Res 17:46–52PubMed
13.
Yang CY, Chiu HF, Tsai SS, Wu TN, Chang CC (2002) Magnesium and calcium in drinking water and the risk of death from esophageal cancer. Magnes Res 15:215–222PubMed
14.
Berndt TJ, Schiavi S, Kumar R (2005) “Phosphatonins” and the regulation of phosphorus homeostasis. Am J Physiol Renal Physiol 289:F1170–F1182CrossRefPubMed
15.
Calvo MS, Park YK (1996) Changing phosphorus content of the U.S. diet: potential for adverse effects on bone. J Nutr 126(4 Suppl):1168S–1180SPubMed
16.
Ames BN (2001) DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res 475:7–20PubMed
17.
Wakai K, Takashi M, Okamura K et al (2000) Foods and nutrients in relation to bladder cancer risk: a case–control study in Aichi Prefecture, Central Japan. Nutr Cancer 38:13–22CrossRefPubMed
18.
Bruemmer B, White E, Vaughan TL, Cheney CL (1996) Nutrient intake in relation to bladder cancer among middle-aged men and women. Am J Epidemiol 144:485–495PubMed
19.
Garcia-Closas R, Garcia-Closas M, Kogevinas M et al (2007) Food, nutrient and heterocyclic amine intake and the risk of bladder cancer. Eur J Cancer 43:1731–1740CrossRefPubMed
20.
Kellen E, Zeegers M, Lousbergh D, Paulussen A, Buntinx F (2005) A Belgian case control study on bladder cancer: rationale and design. Arch Public Health 63:17–34
21.
Iacoviello L, Arnout J, Buntinx F et al (2001) Dietary habit profile in European communities with different risk of myocardial infarction: the impact of migration as a model of gene-environment interaction. The IMMIDIET Study. Nutr Metab Cardiovasc Dis 11:122–126PubMed
22.
Brinkman MT, Kellen E, Zeegers MP et al (2010) Validation of the IMMIDIET Food Frequency Questionnaire in an adult Belgian population: a report from the Belgian case–control study on bladder cancer risk. Acta Clin Belg ‘in preparation’
23.
van Dongen MC, Lentjes MA, Wijckmans NE et al (2010) Validation of a food frequency questionnaire for Flemish and Italian-native subjects in Belgium: the IMMIDIET study. Nutrition [Epub ahead of print]
24.
Nevo Table (2001) Dutch composition table. The Netherlands Nutrition Centre, The Hague
25.
VZW Nubel (1999) Belgian foodtable, third edition. Brussels
26.
Institut Paul Lambin (2000) IPL: table de composition des aliments. Brussels
27.
Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N (2004) Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 96:434–442CrossRefPubMed
28.
Kellen E, Zeegers M, Paulussen A et al (2007) Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer? The Belgian case control study on bladder cancer risk. Cancer Lett 245:51–60CrossRefPubMed
29.
Sellke T, Bayarri MJ, Berger JO (2001) Calibration of P-values for testing precise null hypotheses. Am Stat 55:62–71CrossRef
30.
StataCorp (2009) Stata/IC 10. College Station, Texas
31.
Kelemen LE, Wang SS, Lim U et al (2008) Vegetables- and antioxidant-related nutrients, genetic susceptibility, and non-Hodgkin lymphoma risk. Cancer Causes Control 19:491–503CrossRefPubMed
32.
World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. AICR, Washington, DC
33.
Chan JM, Giovannucci EL (2001) Dairy products, calcium, and vitamin D and risk of prostate cancer. Epidemiol Rev 23:87–92PubMed
34.
Giovannucci E, Liu Y, Stampfer MJ, Willett WC (2006) A prospective study of calcium intake and incident and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev 15:203–210CrossRefPubMed
35.
Cashman KD (2007) Diet, nutrition, and bone health. J Nutr 137:2507S–2512SPubMed
36.
Boscoe FP, Schymura MJ (2006) Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993–2002. BMC Cancer 6:264CrossRefPubMed
37.
Brot C, Jorgensen NR, Sorensen OH (1999) The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr 53:920–926CrossRefPubMed
38.
Deeb KK, Trump DL, Johnson CS (2007) Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 7:684–700CrossRefPubMed
39.
Brot C, Jorgensen N, Madsen OR, Jensen LB, Sorensen OH (1999) Relationships between bone mineral density, serum vitamin D metabolites and calcium: phosphorus intake in healthy perimenopausal women. J Intern Med 245:509–516CrossRefPubMed
40.
Dai Q, Shrubsole MJ, Ness RM et al (2007) The relation of magnesium and calcium intakes and a genetic polymorphism in the magnesium transporter to colorectal neoplasia risk. Am J Clin Nutr 86:743–751PubMed
41.
Shils ME, Rude RK (1996) Deliberations and evaluations of the approaches, endpoints and paradigms for magnesium dietary recommendations. J Nutr 126:2398S–2403SPubMed
42.
Kellen E, Zeegers M, Buntinx F (2006) Selenium is inversely associated with bladder cancer risk: a report from the Belgian case–control study on bladder cancer. Int J Urol 13:1180–1184CrossRefPubMed
43.
Willett W (2003) Invited commentary: OPEN question. Am J Epidemiol 158:22–24CrossRef
44.
Kellen E, Zeegers M, Paulussen A, Van Dongen M, Buntinx F (2006) Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer. Int J Cancer 118:2572–2578CrossRefPubMed
Metadata
Title
Dietary intake of micronutrients and the risk of developing bladder cancer: results from the Belgian case–control study on bladder cancer risk
Authors
Maree T. Brinkman
Frank Buntinx
Eliane Kellen
Pieter C. Dagnelie
Martien C. J. M. Van Dongen
Erik Muls
Maurice P. Zeegers
Publication date
01-03-2011
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 3/2011
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-010-9718-z

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