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Cancer Causes & Control
Published in: Cancer Causes & Control 4/2010

Open Access 01-04-2010 | Original paper

Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study

Authors: Maree T. Brinkman, Margaret R. Karagas, Michael Scott Zens, Alan Schned, Raoul C. Reulen, Maurice P. Zeegers

Published in: Cancer Causes & Control | Issue 4/2010

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Abstract

Objective

Although the effect of fruit and vegetables on the risk of bladder cancer has been widely studied, little is known about their micronutrient components. Our aim was to investigate associations between minerals and vitamins and bladder cancer.

Methods

A case–control study was conducted in New Hampshire, USA. Dietary data were collected from 322 cases and 239 controls using a 121-item food frequency questionnaire. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression adjusting for sex, age, smoking characteristics, and energy intake.

Results

The ORs (95% CI) for highest quartile versus lowest quartile for total intake of vitamin E was 0.66 (0.36–1.20; p trend = 0.09) and 0.49 (0.21–1.17; p trend = 0.13) for dietary phosphorus. The odds of bladder cancer for heavy smokers with the highest total intake of vitamin E, carotenoids, and niacin were 0.58 (0.34–0.99), 0.62 (0.36–1.09), and 0.66 (0.39–1.14), respectively. Higher total intakes of carotenoids, vitamin D, thiamin, niacin, and vitamin E were inversely related to bladder cancer risk among older individuals.

Conclusion

Our findings suggest further investigation of the effect of vitamin E, carotenoids, vitamin D, thiamin, and niacin on bladder cancer risk may be warranted. Future studies should focus on high risk groups such as heavy smokers and older individuals.
Literature
1.
Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108CrossRefPubMed
2.
National Cancer Institute (NCI) (2009) US National Institutes of Health. [cited 2009 October 20]; Available from: www.​cancer.​gov
3.
Holick CN, De Vivo I, Feskanich D, Giovannucci E, Stampfer M, Michaud DS (2005) Intake of fruits and vegetables, carotenoids, folate, and vitamins A, C, E and risk of bladder cancer among women (United States). Cancer Causes Control 16:1135–1145CrossRefPubMed
4.
Grossman HB, Stenzl A, Moyad MA, Droller MJ (2008) Bladder cancer: chemoprevention, complementary approaches and budgetary considerations. Scand J Urol Nephrol Suppl 42:213–233CrossRef
5.
Pelucchi C, Bosetti C, Negri E, Malvezzi M, La Vecchia C (2006) Mechanisms of disease: the epidemiology of bladder cancer. Nat Clin Pract Urol 3:327–340CrossRefPubMed
6.
Brown LM, Zahm SH, Hoover RN, Fraumeni JF Jr (1995) High bladder cancer mortality in rural New England (United States): an etiologic study. Cancer Causes Control 6:361–368CrossRefPubMed
7.
Riboli E, Norat T (2003) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78:559S–569SPubMed
8.
Castelao JE, Yuan JM, Gago-Dominguez M et al (2004) Carotenoids/vitamin C and smoking-related bladder cancer. Int J Cancer 110:417–423CrossRefPubMed
9.
Zeegers MP, Goldbohm RA, van den Brandt PA (2001) Consumption of vegetables and fruits and urothelial cancer incidence: a prospective study. Cancer Epidemiol Biomarkers Prev 10:1121–1128PubMed
10.
Steinmaus CM, Nunez S, Smith AH (2000) Diet and bladder cancer: a meta-analysis of six dietary variables. Am J Epidemiol 151:693–702PubMed
11.
Sacerdote C, Matullo G, Polidoro S et al (2007) Intake of fruits and vegetables and polymorphisms in DNA repair genes in bladder cancer. Mutagenesis 22:281–285CrossRefPubMed
12.
Lin J, Kamat A, Gu J et al (2009) Dietary intake of vegetables and fruits and the modification effects of GSTM1 and NAT2 genotypes on bladder cancer risk. Cancer Epidemiol Biomarkers Prev 18:2090–2097CrossRefPubMed
13.
Tang L, Zirpoli GR, Guru K et al (2008) Consumption of raw cruciferous vegetables is inversely associated with bladder cancer risk. Cancer Epidemiol Biomarkers Prev 17:938–944CrossRefPubMed
14.
Kellen E, Zeegers M, Paulussen A, Van Dongen M, Buntinx F (2006) Fruit consumption reduces the effect of smoking on bladder cancer risk. The Belgian case control study on bladder cancer. Int J Cancer 118:2572–2578CrossRefPubMed
15.
World Cancer Research Fund/American Institute for Cancer (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. AICR, Washington DC
16.
Brinkman M, Zeegers MP (2008) Nutrition, total fluid and bladder cancer. Scand J Urol Nephrol Suppl 42:25–36CrossRef
17.
Steineck G, Hagman U, Gerhardsson M, Norell SE (1990) Vitamin A supplements, fried foods, fat and urothelial cancer. A case-referent study in Stockholm in 1985–1987. Int J Cancer 45:1006–1011CrossRefPubMed
18.
La Vecchia C, Negri E, Decarli A, D’Avanzo B, Liberati C, Franceschi S (1989) Dietary factors in the risk of bladder cancer. Nutr Cancer 12:93–101CrossRefPubMed
19.
Michaud DS, Pietinen P, Taylor PR, Virtanen M, Virtamo J, Albanes D (2002) Intakes of fruits and vegetables, carotenoids and vitamins A, E, C in relation to the risk of bladder cancer in the ATBC cohort study. Br J Cancer 87:960–965CrossRefPubMed
20.
Michaud DS, Spiegelman D, Clinton SK, Rimm EB, Willett WC, Giovannucci EL (2000) Prospective study of dietary supplements, macronutrients, micronutrients, and risk of bladder cancer in US men. Am J Epidemiol 152:1145–1153CrossRefPubMed
21.
Zeegers MP, Goldbohm RA, van den Brandt PA (2001) Are retinol, vitamin C, vitamin E, folate and carotenoids intake associated with bladder cancer risk? Results from the Netherlands Cohort Study. Br J Cancer 85:977–983CrossRefPubMed
22.
Schabath MB, Grossman HB, Delclos GL et al (2004) Dietary carotenoids and genetic instability modify bladder cancer risk. J Nutr 134:3362–3369PubMed
23.
Vena JE, Graham S, Freudenheim J et al (1992) Diet in the epidemiology of bladder cancer in western New York. Nutr Cancer 18:255–264CrossRefPubMed
24.
25.
Roswall N, Olsen A, Christensen J, Dragsted LO, Overvad K, Tjonneland A (2009) Micronutrient intake and risk of urothelial carcinoma in a prospective Danish cohort. Eur Urol 56:764–770CrossRef
26.
Riboli E, Gonzalez CA, Lopez-Abente G et al (1991) Diet and bladder cancer in Spain: a multi-centre case-control study. Int J Cancer 49:214–219CrossRefPubMed
27.
Liang D, Lin J, Grossman HB et al (2008) Plasma vitamins E and A and risk of bladder cancer: a case-control analysis. Cancer Causes Control 19:981–992PubMed
28.
Garcia-Closas R, Garcia-Closas M, Kogevinas M et al (2007) Food, nutrient and heterocyclic amine intake and the risk of bladder cancer. Eur J Cancer 43:1731–1740CrossRefPubMed
29.
Bruemmer B, White E, Vaughan TL, Cheney CL (1996) Nutrient intake in relation to bladder cancer among middle-aged men and women. Am J Epidemiol 144:485–495PubMed
30.
Garcia R, Gonzalez CA, Agudo A, Riboli E (1999) High intake of specific carotenoids and flavonoids does not reduce the risk of bladder cancer. Nutr Cancer 35:212–214CrossRefPubMed
31.
Virtamo J, Edwards BK, Virtanen M et al (2000) Effects of supplemental alpha-tocopherol and beta-carotene on urinary tract cancer: incidence and mortality in a controlled trial (Finland). Cancer Causes Control 11:933–939CrossRefPubMed
32.
Nomura AM, Kolonel LN, Hankin JH, Yoshizawa CN (1991) Dietary factors in cancer of the lower urinary tract. Int J Cancer 48:199–205CrossRefPubMed
33.
Shibata A, Paganini-Hill A, Ross RK, Henderson BE (1992) Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective study. Br J Cancer 66:673–679PubMed
34.
Ames BN (2001) DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutat Res 475:7–20PubMed
35.
Schabath MB, Spitz MR, Lerner SP et al (2005) Case-control analysis of dietary folate and risk of bladder cancer. Nutr Cancer 53:144–151CrossRefPubMed
36.
Cohen SM (1995) Role of urinary physiology and chemistry in bladder carcinogenesis. Food Chem Toxicol 33:715–730CrossRefPubMed
37.
Michaud DS, Clinton SK, Rimm EB, Willett WC, Giovannucci E (2001) Risk of bladder cancer by geographic region in a U.S. cohort of male health professionals. Epidemiology 12:719–726CrossRefPubMed
38.
Karagas MR, Tosteson TD, Blum J, Morris JS, Baron JA, Klaue B (1998) Design of an epidemiologic study of drinking water arsenic exposure and skin and bladder cancer risk in a U.S. population. Environ Health Perspect 106:1047–1050CrossRefPubMed
39.
Fortuny J, Kogevinas M, Zens MS et al (2007) Analgesic and anti-inflammatory drug use and risk of bladder cancer: a population based case control study. BMC Urol 7:13CrossRefPubMed
40.
Applebaum KM, Karagas MR, Hunter DJ et al (2007) Polymorphisms in nucleotide excision repair genes, arsenic exposure, and non-melanoma skin cancer in New Hampshire. Environ Health Perspect 115:1231–1236CrossRefPubMed
41.
Karagas MR, Park S, Warren A et al (2005) Gender, smoking, glutathione-S-transferase variants and bladder cancer incidence: a population-based study. Cancer Lett 219:63–69CrossRefPubMed
42.
Karagas MR, Stukel TA, Morris JS et al (2001) Skin cancer risk in relation to toenail arsenic concentrations in a US population-based case-control study. Am J Epidemiol 153:559–565CrossRefPubMed
43.
Salvini S, Hunter DJ, Sampson L et al (1989) Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. Int J Epidemiol 18:858–867CrossRefPubMed
44.
Michaud DS, Spiegelman D, Clinton SK, Rimm EB, Willett WC, Giovannucci EL (1999) Fruit and vegetable intake and incidence of bladder cancer in a male prospective cohort. J Natl Cancer Inst 91:605–613CrossRefPubMed
45.
United States Department of Agriculture (USDA) (1993) Composition of foods-raw, processed and prepared, 1963–1992: agricultural handbook no. 8 series. Department of Agriculture, Washington, DC
46.
Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N (2004) Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst 96:434–442PubMed
47.
Kellen E, Zeegers M, Paulussen A et al (2007) Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk. Cancer Lett 245:51–60CrossRefPubMed
48.
Hung RJ, Zhang ZF, Rao JY et al (2006) Protective effects of plasma carotenoids on the risk of bladder cancer. J Urol 176:1192–1197CrossRefPubMed
49.
Messina M, Lampe JW, Birt DF et al (2001) Reductionism and the narrowing nutrition perspective: time for reevaluation and emphasis on food synergy. J Am Diet Assoc 101:1416–1419CrossRefPubMed
50.
Konety BR, Lavelle JP, Pirtskalaishvili G et al (2001) Effects of vitamin D (calcitriol) on transitional cell carcinoma of the bladder in vitro and in vivo. J Urol 165:253–258CrossRefPubMed
51.
Willett W (2003) Invited commentary: OPEN question. Am J Epidemiol 158:22–24CrossRef
52.
Berndt TJ, Schiavi S, Kumar R (2005) “Phosphatonins” and the regulation of phosphorus homeostasis. Am J Physiol Renal Physiol 289:F1170–F1182CrossRefPubMed
53.
Kirkali Z, Chan T, Manoharan M et al (2005) Bladder cancer: epidemiology, staging and grading, and diagnosis. Urology 66:4–34CrossRefPubMed
54.
Dharmarajan TS, Kanagala MR, Murakonda P, Lebelt AS, Norkus EP (2008) Do acid-lowering agents affect vitamin B12 status in older adults? J Am Med Dir Assoc 9:162–167CrossRefPubMed
55.
Matullo G, Berwick M, Vineis P (2005) Gene-environment interactions: how many false positives? J Natl Cancer Inst 97:550–551PubMedCrossRef
Metadata
Title
Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study
Authors
Maree T. Brinkman
Margaret R. Karagas
Michael Scott Zens
Alan Schned
Raoul C. Reulen
Maurice P. Zeegers
Publication date
01-04-2010
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 4/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-009-9490-0

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