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European Archives of Oto-Rhino-Laryngology
Published in: European Archives of Oto-Rhino-Laryngology 1/2024

Open Access 12-10-2023 | Diclofenac | Laryngology

Exploring the anti-inflammatory potential of topical hyaluronic acid for vocal fold injury in a rat model

Authors: David Hortobagyi, Tanja Grossmann, Andrijana Kirsch, Christina Winter, Eva Roblegg, Markus Gugatschka

Published in: European Archives of Oto-Rhino-Laryngology | Issue 1/2024

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Abstract

Purpose

Vocal fold injuries are associated with fibrosis and dysphonia, which is a major obstacle to surgical treatment. The aim of this study is to evaluate the effect of topical hyaluronic acid with or without diclofenac on the inflammatory phase of vocal fold wound healing.

Methods

Forty-one male Sprague–Dawley rats were randomly assigned to four groups: an uninjured control group, an injured control group without any treatment, and two intervention groups in which hyaluronic acid with or without diclofenac was applied to the injured vocal fold. Gene expression of inflammatory markers and ECM-related molecules were examined.

Results

Vocal fold injury resulted in a significant upregulation of inflammatory parameters [Ptgs2, Il1b and Il10] and Has1. Tgfb1, Has3 and Eln gene expression were significantly downregulated by the topical application of hyaluronic acid. The combination of hyaluronic acid and diclofenac did not result in any significant changes.

Conclusions

Vocal fold wound healing was significantly improved by a single post-operative topical application of hyaluronic acid. The addition of diclofenac may provide no additional benefit.
Appendix
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Metadata
Title
Exploring the anti-inflammatory potential of topical hyaluronic acid for vocal fold injury in a rat model
Authors
David Hortobagyi
Tanja Grossmann
Andrijana Kirsch
Christina Winter
Eva Roblegg
Markus Gugatschka
Publication date
12-10-2023
Publisher
Springer Berlin Heidelberg
Keyword
Diclofenac
Published in
European Archives of Oto-Rhino-Laryngology / Issue 1/2024
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-023-08278-1

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