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Open Access 01-04-2014 | Poster presentation

Diagnostic and prognostic evaluation of soluble CD14 subtype for sepsis in critically ill patients: a preliminary study

Authors: A Foca, C Peronace, V Marano, GS Barreca, AG Lamberti, N Marascio, A Giancotti, R Puccio, MC Liberto

Published in: Critical Care | Special Issue 2/2014

Excerpt

Sepsis, a leading cause of death in critical care patients, is the result of complex interactions between the infecting microorganisms and the host responses that influence clinical outcomes [1]. Reliable biochemical markers that enable early diagnosis are still needed. A new marker, presepsin (soluble CD14 subtype, sCD14-ST) is a circulating fragment of 13 kDa of soluble CD14 that originates from the cleavage of the CD14 expressed on the surface membranes of monocytes/macrophages. sCD14-ST has been shown to increase significantly in patients with sepsis [2]. In our study we compare diagnostic performance of presepsin, C-reactive protein (CRP) and procalcitonin (PCT). …

Masson S, Caironi P, Spanuth E, Thomae R, Panigada M, Sangiorgi G, Fumagalli R, Mauri T, Isgrò S, Fanizza C, et al.: Presepsin (soluble CD14 subtype) and procalcitonin levels for mortality prediction in sepsis: data from the Albumin Italian Outcome Sepsis trial. Crit Care 2014, 18: R6. 10.1186/cc13183CrossRefPubMedPubMedCentral

Yaegashi Y, Shirakawa K, Sato N, Suzuki Y, Kojika M, Imai S, Takahashi G, Miyata M, Furusako S, Endo S: Evaluation of a newly identified soluble CD14 subtype as a marker for sepsis. J Infect Chemother 2005, 11: 234-238. 10.1007/s10156-005-0400-4CrossRefPubMed

Ulla M, Pizzolato E, Lucchiari M, Loiacono M, Soardo F, Forno D, Morello F, Lupia E, Moiraghi C, Mengozzi G, et al.: Diagnostic and prognostic value of presepsin in the management of sepsis in the emergency department: a multicenter prospective study. Crit Care 2013, 17: R168. 10.1186/cc12847CrossRefPubMedPubMedCentral

Endo S, Suzuki Y, Takahashi G, Shozushima T, Ishikura H, Murai A, Nishida T, Irie Y, Miura M, Iguchi H, et al.: Presepsin as a powerful monitoring tool for the prognosis and treatment of sepsis: a multicenter prospective study. J Infect Chemother 2014, 20: 30-34. 10.1016/j.jiac.2013.07.005CrossRefPubMed

Title: Diagnostic and prognostic evaluation of soluble CD14 subtype for sepsis in critically ill patients: a preliminary study
Authors: A Foca
C Peronace
V Marano
GS Barreca
AG Lamberti
N Marascio
A Giancotti
R Puccio
MC Liberto
Publication date: 01-04-2014
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 2/2014
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc14053

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Diagnostic and prognostic evaluation of soluble CD14 subtype for sepsis in critically ill patients: a preliminary study

Excerpt

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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