Published in:
Open Access
01-04-2014 | Poster presentation
Inhibitory effects of evodiamine on zymosan-induced inflammation: inactivation of NF-κB by inhibiting IκBα phosphorylation
Authors:
X Fan, J-y Zhu, Z Liu, J Yan, Q Ma, H-p Liang
Published in:
Critical Care
|
Special Issue 2/2014
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Excerpt
Inflammation is a host defense reaction against pathogenic infection. In this process, inflammatory cytokines contribute to combat against infection, but excess cytokines will lead to tissue damage. Nonsteroidal anti-inflammatory drugs and corticosteroids are commonly used for regulating these inflammatory mediators and treatment of inflammatory disorders. But these drugs are not sufficient for clinical practice due to their adverse effects, so new anti-inflammatory drugs are still needed. Evodiamine (EVO), an important alkaloidal component extracted from the fruit of Evodiae fructus, possesses the property of analgesia, antiemesis, and vascular dilatation. Its anti-inflammatory effect and underlying mechanism were investigated using a zymosan-induced inflammatory model. …