Diabetologia

Type 1 diabetes in the young: the harvest of sorrow goes on

E. A. M. Gale

The changing epidemiology of diabetic microangiopathy in type 1 diabetes

P. Rossing

Atherosclerosis in childhood and adolescent type 1 diabetes: early disease, early treatment?

K. Dahl-Jørgensen, J. R. Larsen, K. F. Hanssen

Is there really an epidemic of diabetes?

N. J. Wareham, N. G. Forouhi

The epidemic of type 2 diabetes is a statistical artefact

A. Green, H. Støvring, M. Andersen, H. Beck-Nielsen

There really is an epidemic of type 2 diabetes

S. Colagiuri, K. Borch-Johnsen, C. Glümer, D. Vistisen

Lack of effect of intermittently administered sodium fusidate in patients with newly diagnosed type 1 diabetes mellitus: the FUSIDM trial

I. Conget, E. Aguilera, S. Pellitero, S. Näf, K. Bendtzen, R. Casamitjana, R. Gomis, F. Nicoletti

A prospective study of lipoprotein(a) and risk of coronary heart disease among women with type 2 diabetes

I. Shai, M. B. Schulze, J. E. Manson, M. J. Stampfer, N. Rifai, F. B. Hu

Urinary sodium and potassium excretion and the risk of type 2 diabetes: a prospective study in Finland

G. Hu, P. Jousilahti, M. Peltonen, J. Lindström, J. Tuomilehto

Diabetes-associated HLA genotypes affect birthweight in the general population

H. E. Larsson, K. Lynch, B. Lernmark, A. Nilsson, G. Hansson, P. Almgren, Å. Lernmark, S-A. Ivarsson

The –174 IL-6 GG genotype is associated with a reduced risk of type 2 diabetes mellitus in a family sample from the National Heart, Lung and Blood Institute’s Framingham Heart Study

A. Herbert, C. Liu, S. Karamohamed, J. Schiller, J. Liu, Q. Yang, P. W. F. Wilson, L. A. Cupples, J. B. Meigs

The Pro12Ala and C–681G variants of the PPARG locus are associated with opposing growth phenotypes in young schoolchildren

J. E. Cecil, B. Fischer, A. S. F. Doney, M. Hetherington, P. Watt, W. Wrieden, C. Bolton-Smith, C. N. A. Palmer

Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes

K. B. Adamo, R. J. Sigal, K. Williams, G. Kenny, D. Prud’homme, F. Tesson

Global profiling of coxsackievirus- and cytokine-induced gene expression in human pancreatic islets

P. Ylipaasto, B. Kutlu, S. Rasilainen, J. Rasschaert, K. Salmela, H. Teerijoki, O. Korsgren, R. Lahesmaa, T. Hovi, D. L. Eizirik, T. Otonkoski, M. Roivainen

Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells

Domenico Bosco, Paolo Meda, Philippe Morel, David Matthey-Doret, Dorothée Caille, Christian Toso, Leo H. Bühler, Thierry Berney

The Rap–B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells

J. Trümper, D. Ross, H. Jahr, M. D. Brendel, R. Göke, D. Hörsch

Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines

S. Lortz, E. Gurgul-Convey, S. Lenzen, M. Tiedge

Mitochondrial regulation of insulin production in rat pancreatic islets

G. Leibowitz, M. Z. Khaldi, A. Shauer, M. Parnes, A. I. Oprescu, E. Cerasi, J.-C. Jonas, N. Kaiser

Pancreatic beta and alpha cells are both decreased in patients with fulminant type 1 diabetes: a morphometrical assessment

K. Sayama, A. Imagawa, K. Okita, S. Uno, M. Moriwaki, J. Kozawa, H. Iwahashi, K. Yamagata, S. Tamura, Y. Matsuzawa, T. Hanafusa, J. Miyagawa, I. Shimomura

Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouse

F. Calcinaro, S. Dionisi, M. Marinaro, P. Candeloro, V. Bonato, S. Marzotti, R. B. Corneli, E. Ferretti, A. Gulino, F. Grasso, C. De Simone, U. Di Mario, A. Falorni, M. Boirivant, F. Dotta

Wheat protein-induced proinflammatory T helper 1 bias in mesenteric lymph nodes of young diabetes-prone rats

H. Chakir, D. E. Lefebvre, H. Wang, E. Caraher, F. W. Scott

Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy

G. D. Tan, C. Debard, T. Funahashi, S. M. Humphreys, Y. Matsuzawa, K. N. Frayn, F. Karpe, H. Vidal

Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes

N. Ahmed, R. Babaei-Jadidi, S. K. Howell, P. J. Beisswenger, P. J. Thornalley

Heritability of model-derived parameters of beta cell secretion during intravenous and oral glucose tolerance tests: a study of twins

M. Lehtovirta, J. Kaprio, L. Groop, M. Trombetta, R. C. Bonadonna

Implantation of primary cultured adipocytes that secrete insulin modifies blood glucose levels in diabetic mice

M. Ito, H. Bujo, K. Takahashi, T. Arai, I. Tanaka, Y. Saito

Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice

A. C. Heijboer, A. M. van den Hoek, H. Pijl, P. J. Voshol, L. M. Havekes, J. A. Romijn, E. P. M. Corssmit

Protein kinase-ζ interacts with munc18c: role in GLUT4 trafficking

C. P. Hodgkinson, A. Mander, G. J. Sale

Increased accumulation of skin advanced glycation end-products precedes and correlates with clinical manifestation of diabetic neuropathy

R. Meerwaldt, T. P. Links, R. Graaff, K. Hoogenberg, J. D. Lefrandt, J. W. Baynes, R. O. B. Gans, A. J. Smit

Renal accumulation and clearance of advanced glycation end-products in type 2 diabetic nephropathy: effect of angiotensin-converting enzyme and vasopeptidase inhibition

C. Wihler, S. Schäfer, K. Schmid, E. K. Deemer, G. Münch, M. Bleich, A. E. Busch, T. Dingermann, V. Somoza, J. W. Baynes, J. Huber

Increased augmentation of central blood pressure is associated with increases in carotid intima–media thickness in type 2 diabetic patients

J. Westerbacka, E. Leinonen, J. T. Salonen, R. Salonen, A. Hiukka, H. Yki-Järvinen, M.-R. Taskinen

Retinal neovascularisation without ischaemia in the spontaneously diabetic Torii rat

H. Yamada, E. Yamada, A. Higuchi, M. Matsumura

Diabetic cardiomyopathy in uncomplicated type 2 diabetes is associated with the metabolic syndrome and systemic inflammation

M. Diamant, H. J. Lamb, J. W. A. Smit, A. de Roos, R. J. Heine

Atorvastatin does not decrease or delay diabetes onset in two different mouse models of type 1 diabetes

X. Palomer, L. Calpe-Berdiel, J. Verdaguer, J. Carrillo, X. Pastor, D. Mauricio, F. Blanco-Vaca

–to: Wu AYT, Kong NCT, de Leon FA, Pan CY, Tai TY, Yeung VTF, Yoo SJ, Rouillon A, Weir MR, for the MAPS investigators (2005) An alarming high prevalence of diabetic nephropathy in Asian type 2 diabetic patients: the MicroAlbuminuria Prevalence (MAP) Study. Diabetologia 48: 17–26

C. Rattarasarn

Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study

H. K. Åkerblom, S. M. Virtanen, J. Ilonen, E. Savilahti, O. Vaarala, A. Reunanen, K. Teramo, A.-M. Hämäläinen, J. Paronen, M.-A. Riikjärv, A. Ormisson, J. Ludvigsson, H.-M. Dosch, T. Hakulinen, M. Knip

An immune origin of type 2 diabetes?

H. Kolb, T. Mandrup-Poulsen

Genome-wide scans for heritability of fasting serum insulin and glucose concentrations in hypertensive families

B. I. Freedman, S. S. Rich, M. M. Sale, G. Heiss, L. Djoussé, J. S. Pankow, M. A. Province, D. C. Rao, C. E. Lewis, Y. D. I. Chen, S. R. Beck

EASD News Section August 2005