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International Ophthalmology

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01-12-2024 | Diabetic Retinopathy | Review

Review of lipocalin-2-mediated effects in diabetic retinopathy

Authors: Yajuan Zhang, Xiaojun Song, Tianying Qi, Xinli Zhou

Published in: International Ophthalmology | Issue 1/2024

Abstract

Background

Studies have uncovered LCN2 as a marker of inflammation strongly related to obesity, insulin resistance, and abnormal glucose metabolism in humans, and is involved in vascular diseases, inflammatory diseases, and neurological diseases. In recent years, studies have shown that elevated levels of LCN2 have a strong association with diabetic retinopathy (DR), but the pathogenesis is unknown. Here, we reviewed the relevant literature and compiled the pathogenesis associated with LCN2-induced DR.

Methods

We searched PubMed and Web of Science electronic databases using “lipocalin-2, diabetic retinopathy, retinal degeneration, diabetic microangiopathies, diabetic neuropathy and inflammation” as subject terms.

Results

In diabetic retinal neuropathy, LCN2 causes impaired retinal photoreceptor function and retinal neurons; in retinal microangiopathy, LCN2 induces apoptosis of retinal vascular endothelial cells and promotes angiogenesis; in retinal inflammation, increased secretion of LCN2 recruits inflammatory cells and induces pro-inflammatory cytokines. Moreover, LCN2 has the potential as a biomarker for DR. Recent studies have shown that retinal damage can be attenuated by silencing LCN2, which may be associated with the inhibition of caspase-1-mediated pyroptosis, and LCN2 may be a new target for the treatment of DR.

Conclusions

In conclusion, LCN2, involved in the development of diabetic retinopathy, is a key factor in diabetic retinal microangiopathy, neurodegeneration, and retinal inflammation. LCN2 is likely to be a novel molecular target leading to DR, and a more in-depth study of the pathogenesis of DR caused by LCN2 may provide considerable benefits for clinical research and potential drug development.

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Title: Review of lipocalin-2-mediated effects in diabetic retinopathy
Authors: Yajuan Zhang
Xiaojun Song
Tianying Qi
Xinli Zhou
Publication date: 01-12-2024
Publisher: Springer Netherlands
Keywords: Diabetic Retinopathy
Diabetic Retinopathy
Diabetic Neuropathy
Diabetic Neuropathy
Published in: International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-024-03015-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Review of lipocalin-2-mediated effects in diabetic retinopathy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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