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Published in: Diabetologia 10/2014

01-10-2014 | Commentary

Diabetes and bone fracture: risk factors for old and young

Author: Peter Vestergaard

Published in: Diabetologia | Issue 10/2014

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Abstract

Diabetes mellitus may affect bone turnover in a number of ways, thus leading to impaired bone quality and a consequent increase in fracture risk. These factors are summarised in this commentary.
Literature
1.
go back to reference Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98–107PubMedCrossRef Donath MY, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98–107PubMedCrossRef
2.
go back to reference Valcourt U, Merle B, Gineyts E et al (2007) Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation. J Biol Chem 282:5691–5703PubMedCrossRef Valcourt U, Merle B, Gineyts E et al (2007) Non-enzymatic glycation of bone collagen modifies osteoclastic activity and differentiation. J Biol Chem 282:5691–5703PubMedCrossRef
3.
go back to reference Jiajue R, Jiang Y, Wang O et al (2014) Suppressed bone turnover was associated with increased osteoporotic fracture risks in non-obese postmenopausal Chinese women with type 2 diabetes mellitus. Osteoporos Int. 25:1999–2005 Jiajue R, Jiang Y, Wang O et al (2014) Suppressed bone turnover was associated with increased osteoporotic fracture risks in non-obese postmenopausal Chinese women with type 2 diabetes mellitus. Osteoporos Int. 25:1999–2005
5.
go back to reference Kindblom JM, Ohlsson C, Ljunggren O et al (2009) Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res 24:867–874CrossRef Kindblom JM, Ohlsson C, Ljunggren O et al (2009) Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res 24:867–874CrossRef
6.
go back to reference Saito M, Marumo K (2010) Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int 21:195–214PubMedCrossRef Saito M, Marumo K (2010) Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int 21:195–214PubMedCrossRef
7.
go back to reference Jehle PM, Jehle DR, Mohan S et al (1998) Serum levels of insulin-like growth factor system components and relationship to bone metabolism in type 1 and type 2 diabetes mellitus patients. J Endocrinol 159:297–306PubMedCrossRef Jehle PM, Jehle DR, Mohan S et al (1998) Serum levels of insulin-like growth factor system components and relationship to bone metabolism in type 1 and type 2 diabetes mellitus patients. J Endocrinol 159:297–306PubMedCrossRef
8.
go back to reference McNair P, Madsbad S, Christensen M et al (1979) Bone mineral loss in insulin-treated diabetes mellitus: studies on pathogenesis. Acta Endocrinol 90:463–472PubMed McNair P, Madsbad S, Christensen M et al (1979) Bone mineral loss in insulin-treated diabetes mellitus: studies on pathogenesis. Acta Endocrinol 90:463–472PubMed
9.
go back to reference Carnevale V, Romagnoli E, D’Erasmo E (2004) Skeletal involvement in patients with diabetes mellitus. Diabetes Metab Res Rev 20:196–204PubMedCrossRef Carnevale V, Romagnoli E, D’Erasmo E (2004) Skeletal involvement in patients with diabetes mellitus. Diabetes Metab Res Rev 20:196–204PubMedCrossRef
11.
go back to reference McNair P, Christensen M, Madsbad S et al (1981) Hypoparathyroidism in diabetes mellitus. Acta Endocrinol (Copenh) 96:81–86 McNair P, Christensen M, Madsbad S et al (1981) Hypoparathyroidism in diabetes mellitus. Acta Endocrinol (Copenh) 96:81–86
12.
go back to reference Abugassa S, Nordenstrom J, Eriksson S et al (1993) Bone mineral density in patients with chronic hypoparathyroidism. J Clin Endocrinol Metab 76:1617–1621PubMed Abugassa S, Nordenstrom J, Eriksson S et al (1993) Bone mineral density in patients with chronic hypoparathyroidism. J Clin Endocrinol Metab 76:1617–1621PubMed
13.
go back to reference Benvenuti S, Cellai I, Luciani P et al (2007) Rosiglitazone stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. J Endocrinol Invest 30:RC26–RC30PubMedCrossRef Benvenuti S, Cellai I, Luciani P et al (2007) Rosiglitazone stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. J Endocrinol Invest 30:RC26–RC30PubMedCrossRef
14.
go back to reference Janghorbani M, van Dam R, Willett W et al (2007) Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 166:495–505PubMedCrossRef Janghorbani M, van Dam R, Willett W et al (2007) Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 166:495–505PubMedCrossRef
15.
go back to reference Vestergaard P (2007) Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—a meta-analysis. Osteoporos Int 18:427–444PubMedCrossRef Vestergaard P (2007) Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—a meta-analysis. Osteoporos Int 18:427–444PubMedCrossRef
17.
go back to reference Strotmeyer E, Cauley J, Schwartz A et al (2005) Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med 165:1612–1617PubMedCrossRef Strotmeyer E, Cauley J, Schwartz A et al (2005) Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med 165:1612–1617PubMedCrossRef
Metadata
Title
Diabetes and bone fracture: risk factors for old and young
Author
Peter Vestergaard
Publication date
01-10-2014
Publisher
Springer Berlin Heidelberg
Published in
Diabetologia / Issue 10/2014
Print ISSN: 0012-186X
Electronic ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-014-3338-1

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