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Published in: Journal of Interventional Cardiac Electrophysiology 3/2020

01-09-2020 | MULTIMEDIA REPORT

Development of a novel ablation hood to prevent systemic embolization of microbubbles and particulate emboli

Authors: Alan Sugrue, Vaibhav Vaidya, Omar Yasin, Ameesh Isath, Anas Abudan, Deepak Padmanabhan, Suraj Kapa, Samuel J. Asirvatham

Published in: Journal of Interventional Cardiac Electrophysiology | Issue 3/2020

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Abstract

Background

Atrial fibrillation ablation results in microbubbles and particulate emboli formation. We aimed to develop and test the early feasibility of a novel ablation hood to contain microbubbles and particulate emboli with the ultimate goal of preventing systemic embolization.

Methods

In seven canines, we developed, iterated, and tested a novel retractable hood that can cover the catheter-tissue ablation site. The number and volume (nL) of microbubbles formed during ablation with and without the hood was measured using an extracorporeal circulation loop. Wilcoxon’s signed-rank test was used to compare the number of bubbles detected with and without the hood.

Results

The hood reduced systemic embolization of microbubbles in 21/28 (75%) of ablations. Both atrial and ventricular ablations showed a statistically significant reduction in bubble number (476 ± 811 without hood vs 173 ± 226 with hood, p = 0.02; 2669 ± 1623 without hood vs 1417 ± 970 with hood, p = 0.04, respectively) and bubble volume (3.3 ± 7.6 nL without hood vs 0.2 ± 0.56 nL with hood, p = 0.006; 6.1 ± 5.2 nL without hood vs 1.9 ± 1.4 nL with hood, p = 0.05, respectively).

Conclusions

Use of a novel hood to cover the ablation catheter at the site of catheter-tissue contact has the potential to provide a means to reduce systematic embolization of microbubbles. Further work is required to examine particulate emboli, but these data show the early feasibility of this design concept.
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Metadata
Title
Development of a novel ablation hood to prevent systemic embolization of microbubbles and particulate emboli
Authors
Alan Sugrue
Vaibhav Vaidya
Omar Yasin
Ameesh Isath
Anas Abudan
Deepak Padmanabhan
Suraj Kapa
Samuel J. Asirvatham
Publication date
01-09-2020
Publisher
Springer US
Published in
Journal of Interventional Cardiac Electrophysiology / Issue 3/2020
Print ISSN: 1383-875X
Electronic ISSN: 1572-8595
DOI
https://doi.org/10.1007/s10840-019-00595-y

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