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BMC Public Health
Published in: BMC Public Health 1/2017

Open Access 01-12-2017 | Study protocol

Development and effectiveness of a mobile phone application conducting health behavioral intervention among men who have sex with men, a randomized controlled trial: study protocol

Authors: Jin Yan, Aidi Zhang, Liang Zhou, Zhulin Huang, Pan Zhang, Guoli Yang

Published in: BMC Public Health | Issue 1/2017

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Abstract

Background

Behavioral intervention is a key approach to HIV prevention among men who have sex with men (MSM). Widespread use of mobile phones provide us with novel opportunities to decrease HIV infection and transmission of MSM. The objective of the study was to design and develop a mobile phone application (app) aims to conduct behavioral intervention to MSM and to evaluate the efficacy of the app-based intervention compared to usual care, to analyze cost-effectiveness and mechanism of the intervention.

Methods

This study involves 2 phases, phase 1 use qualitative method and phase 2 is a randomized controlled trial lasting for 18 months, they will be conducted in Chagnsha, Hunan Province, China. Phase 1 is to design and develop the app, procedures including retrieval of domestic apps related to prevention and treatment about HIV and sexually transmitted diseases (HIV/STDs), personal interviews with MSM about preferences and functional needs of the HIV prevention app, multidisciplinary experts focused group discussions of the app, software engineers’ development and users test of the app will be performed. In phase 2, we will recruit 800 MSM by cooperating with the local center of disease control and prevention and nongovernmental organizations, and divide them into intervention and control group evenly. Intervention group participants will receive app-based HIV prevention. Control group participants will be provided with usual care including HIV/STDs knowledge brochure and free voluntary counseling services. Data will be collected at baseline, 6, 12 and 18 months since subject’s participation. Effectiveness of the intervention includes HIV/STDs infection rates, adherence to regularly HIV testing, sexual risk behavior, consistent condom use and relative risk of HIV infection. Cost-effectiveness will be analyzed by decision-analytic modeling, and mechanism analysis of this app-based intervention will be performed by path analysis.

Discussion

This will be the first study of its kind in China to develop an app and implement app-based HIV prevention intervention among MSM. It is of great potential to determine whether app-based intervention is a cost-effective way to decrease HIV infection among MSM and explore intervention mechanism with an accurate method.

Trial registration

Chinese Clinical Trial Register (ChiCTR-IOR-15006724). Registered 10 July 2015.
Literature
1.
Centers for Disease Control and Prevention (CDC. HIV and AIDS--United States, 1981-2000 [J]. MMWR Morb Mortal Wkly Rep. 2001;50(21):430.
2.
Zheng X. A report on AIDS surveillance report from 1985 to 1988 in China [J]. Chin J Epidemiol. 1989;10:65–7.
3.
Beyrer C, Sullivan P, Sanchez J, Barala SD, Collinsd C, Wirtza AL, et al. The increase in global HIV epidemics in MSM [J]. AIDS. 2013;27(17):2665–78.CrossRefPubMed
4.
Wu ZY. Chinese response on the spread of HIV/AIDS among MSM [C]. National communication about HIV prevention and control among MSM, tenth anniversary of FRIENDS program and Bailey-Martin prize award ceremony, Beijing, 2008.
5.
Chow EP, Wilson DP, Zhang J, Jing J, Zhang L. Human immunodeficiency virus prevalence is increasing among men who have sex with men in China: findings from a review and meta-analysis [J]. Sex Transm Dis. 2011;38(9):845–57.CrossRefPubMed
6.
State Council AIDS Working Committee Office (SCAWCO): 2012 China AIDS. Response progress report [R]. Beijing, China: Ministry of Health of the People’s Republic of China; 2012:70.
7.
Mayer KH, Wheeler DP, Bekker LG, Grinsztejn B, Remien RH, Sandfort TG, Beyrer C. Overcoming biological, behavioral, and structural vulnerabilities: new directions in research to decrease HIV transmission in men who have sex with men [J]. J Acquir Immune Defic Syndr. 2013;63(Suppl.2):S161–7.CrossRefPubMedPubMedCentral
8.
Weiss HA, Quigley MA, Hayes RJ. Male circumcision and risk of HIV infection in sub-Saharan Africa: a systematic review and meta-analysis [J]. AIDS. 2000;14(15):2361–70.CrossRefPubMed
9.
Yan J, Lau JF, Tsui HY, Gu J, Wang ZX. Prevalence and factors associated with condom use among Chinese monogamous female patients with sexually transmitted infection in Hong Kong [J]. J Sex Med. 2012;9:3009–17.CrossRefPubMed
10.
Higa DH, Crepaz H, Marshall KJ, Kay L, Vosburgh HW, Spikes P, et al. A systematic review to identify challenges of demonstrating efficacy of HIV behavioral interventions for gay, bisexual, and other men who have sex with men (MSM) [J]. AIDS Behav. 2013;17(4):1231–44.CrossRefPubMed
11.
Yan J, Xiao SY, Zhou L, Tang Y, Xu GM, Luo D, Yi QF. A social epidemiological study of HIV/AIDS in Henan Province, China [J]. AIDS Care. 2013;25(3):302–8.PubMed
12.
Herbst JH, Sherba RT, Crepaz N, DeLuca JB, Zohrabyan L, Stall RD, Lyles C. The HIV/AIDS prevention research synthesis team. A meta-analytic review of HIV behavioral interventions for reducing sexual risk behavior of men who have sex with men [J]. J Acquir Immune Defic Syndr. 2005;39(2):228–41.PubMed
13.
Dai YB, Zhang YJ, Phatarpekar P, Mi YJ, Zhang H, Blackburn MR, Xia Y. Adenosine signaling, priapism, and novel therapies [J]. J Sex Med. 2009;6(Suppl 3):292–301.CrossRefPubMed
14.
Safren SA, O’Cleirigh CM, Skeer M, Elsesser SA, Mayer KH. Project enhance: a randomized controlled trial of an individualized HIV prevention intervention for HIV-infected men who have sex with men conducted in a primary care setting [J]. Health Psychol. 2013;32(2):171–9.CrossRefPubMed
15.
Mausbach BT, Semple SJ, Strathdee SA, Jim Z, Thomas LP. Efficacy of a behavioral intervention for increasing safer sex behaviors in HIV-positive MSM methamphetamine users: results from the EDGE study [J]. Drug Alcohol Depend. 2006;87:249–57.CrossRefPubMedPubMedCentral
16.
Guo W, Pang L, Wu ZY. Prevention and control progress and main problems among Chinese men who have sex with men [J]. Chin J AIDS STD. 2008;14(3):341–16.
17.
The Healthy Living Project Team. Effects of a behavioral intervention to reduce risk of transmission among people living with HIV: the healthy living project randomized controlled study [J]. J Acquir Immune Defic Syndr. 2007;44:213–21.CrossRef
18.
Hayes R, Ayles H, Beyers N, Hoddinott G, Krishnaratne S, Mathema H, et al. HPTN 071 (PopART): rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment–a study protocol for a cluster randomised trial [J]. Trials. 2014;15(1):1.CrossRef
19.
Sullivan PS, Carballo-Diéguez A, Coates T, Goodreau SM, McGowan I, Sanders EJ, et al. Successes and challenges of HIV prevention in men who have sex with men [J]. Lancet. 2012;380(9839):388–99.CrossRefPubMedPubMedCentral
20.
Lyles CM, Kay LS, Crepaz N, Herbst JH, Passin WF, Kim AS, et al. Best-evidence interventions: findings from a systematic review of HIV behavioral interventions for US populations at high risk, 2000–2004 [J]. Am J Public Health. 2007;97(1):133–43.CrossRefPubMedPubMedCentral
21.
22.
Swendeman D, Rotheram-Borus MJ. Innovation in sexually transmitted disease and HIV prevention: internet and mobile phone delivery vehicles for global diffusion [J]. Curr Opin Psychiatry. 2010;23:139–44.CrossRefPubMedPubMedCentral
23.
Yan J, Ouyang DS. Cost analysis and nursing [J]. Chin J Nurs. 2004;39(5):365–7.
24.
Muessig KE, Pike EC, MSIS BF, LeGrand S, Parsons JT, Bull SS, et al. Putting prevention in their pockets: developing mobile phone-based HIV interventions for black men who have sex with men [J]. AIDS Patient Care STDs. 2013;27(4):211–22.CrossRefPubMedPubMedCentral
25.
Schmidt AJ, Hickson F, Weatherburn P, Marcus U. Comparison of the performance of STI screening services for gay and bisexual men across 40 European cities: results from the European MSM internet survey [J]. Sex Transm Infect. 2013;89(7):575–82.CrossRefPubMed
26.
Magnus M, Herwehe J, Andrews L, Gibson L, Daigrepont N, De Leon JM, et al. Evaluating health information technology: provider satisfaction with an HIV-specific, electronic clinical management and reporting system [J]. AIDS Patient Care STDs. 2009;23:85–91.CrossRefPubMed
27.
Gilbert P, Ciccarone D, Gansky SA, Bangsberg DR, Clanon K, McPhee SJ, et al. Interactive “video doctor” counseling reduces drug and sexual risk behaviors among HIV-positive patients in diverse outpatient settings [J]. Plos One. 2008;3(4):e1988.CrossRefPubMedPubMedCentral
28.
Mikolajczak J, Kok G, Hospers HJ. Queermasters: developing a theory- and evidence-based internet HIV-prevention intervention to promote HIV-testing among men who have sex with men (MSM) [J]. Appl Psychol. 2008;57(4):681–97.CrossRef
29.
Levine D, Woodmff AJ, Mocello AR, et al. inSPOT:the first online STD partner notification system using electronic postcards [J]. PLoS Med. 2008;5(10):e213.CrossRefPubMedPubMedCentral
30.
Zhao HX, Zhao R, Wu WQ. The progress of network investigation and network intervention in the sex healthy among men who have sex with men [J]. Chin J Fam Plann Gynecotokology. 2011;05:75–8.
31.
Liu GW, Lu HY, Wang J, et al. Evaluation of web-based HIV/AIDS interventions among men who have sex with men [J]. Chin J AIDS STD. 2012;09:578–80.
32.
Li XG, Gu XC, Jing J, et al. Study on intemet—based HIV intervention targeted on men who have sex with men [J]. Chin J AIDS STD. 2013;19(8):599–601.
33.
Zhong W, Xu HF, Cheng WB, et al. Easy TellTM: an innovative online sexual partner notification system based on internet and mobile phone [J]. Chin J AIDS STD. 2012;1:41–4.
34.
35.
36.
37.
Goldenberg Y, McDougal SJ, Sullivan PS, et al. Preferences for a mobile HIV prevention app for men who have sex with men. JMIR mHealth uHealth. 2014;2(4):e47.CrossRefPubMedPubMedCentral
38.
Aliabadi N, Carballo-Dieguez A, Bakken S, et al. Using the information-motivation-behavioral skills model to guide the development of an HIV prevention smartphone application for high-risk MSM [J]. AIDS Educ Prev Off Publ Int Soc AIDS Educ. 2015;27(6):522.CrossRef
39.
Yan J, Xiao SY, Zhou L, et al. Development of perceived stigma scale for children affected by HIV/AIDS [J]. Chin J Clin Psych. 2008;16(2):129–30.
40.
Zhou L, Zhang GB, Hu HX, Fan ZJ, Hao W. Perceived interpersonal pressure and drinking behavior in South China [J]. Drug Alcohol Depend. 2013;130:122–8.CrossRefPubMed
41.
42.
43.
Noar SM, Black HG, Pierce LB. Efficacy of computer technology-based HIV prevention interventions: a meta-analysis [J]. AIDS. 2009;23(1):107–15.CrossRefPubMed
44.
Vassilev I, Rowsell A, Pope C, et al. Assessing the implementability of telehealth interventions for self-management support: a realist review [J]. Implement Sci. 2015;10:59.CrossRefPubMedPubMedCentral
45.
Stephens J, Allen J. Mobile phone interventions to increase physical activity and reduce weight: a systematic review [J]. J Cardiovasc Nurs. 2013;28(4):320–9.CrossRefPubMedPubMedCentral
46.
Duncan M, Vandelanotte C, Kolt GS, et al. Effectiveness of a web-and mobile phone-based intervention to promote physical activity and healthy eating in middle-aged males: randomized controlled trial of the ManUp study [J]. J Med Internet Res. 2014;16(6):e136.CrossRefPubMedPubMedCentral
Metadata
Title
Development and effectiveness of a mobile phone application conducting health behavioral intervention among men who have sex with men, a randomized controlled trial: study protocol
Authors
Jin Yan
Aidi Zhang
Liang Zhou
Zhulin Huang
Pan Zhang
Guoli Yang
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2017
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/s12889-017-4235-6

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