Skip to main content
Top
Published in: Journal of Nuclear Cardiology 1/2009

01-02-2009 | Editorial

Detection of multivessel coronary artery disease: looking beyond the extent of perfusion abnormalities

Authors: Dipan Desai, DO, Gorgi Kozeski, DO, Olakunle Akinboboye, MD

Published in: Journal of Nuclear Cardiology | Issue 1/2009

Login to get access

Excerpt

The sensitivity of stress myocardial perfusion scintigraphy for detecting coronary artery disease (CAD) in patients with multivessel CAD is high.1-4 However, its ability to predict the presence of multivessel disease is limited. It has been suggested that the presence of left main or multivessel disease is missed in up to 50% of cases.5,6 The possible reasons for this include balanced perfusion abnormality, where the absence of a normal reference segment limits sensitivity, early plateau of tracer uptake, which limits detection of borderline stenoses, and early stoppage of exercise as a result of symptoms or signs due to the severest lesion. …
Literature
1.
go back to reference Sharir T, Bacher-Stier C, Dhar S, et al. Identification of severe and extensive coronary artery disease by postexercise regional wall motion abnormalities in Tc-99m sestamibi gated single-photon emission computed tomography. Am J Cardiol 2000;86:1171-5.PubMedCrossRef Sharir T, Bacher-Stier C, Dhar S, et al. Identification of severe and extensive coronary artery disease by postexercise regional wall motion abnormalities in Tc-99m sestamibi gated single-photon emission computed tomography. Am J Cardiol 2000;86:1171-5.PubMedCrossRef
2.
go back to reference Yamagishi H, Shirai N, Yoshiyama M, et al. Incremental value of left ventricular ejection fraction for detection of multivessel coronary artery disease in exercise (201)Tl gated myocardial perfusion imaging. J Nucl Med 2002;43:131-9.PubMed Yamagishi H, Shirai N, Yoshiyama M, et al. Incremental value of left ventricular ejection fraction for detection of multivessel coronary artery disease in exercise (201)Tl gated myocardial perfusion imaging. J Nucl Med 2002;43:131-9.PubMed
3.
go back to reference Lima RS, Watson DD, Goode AR, et al. Incremental value of combined perfusion and function over perfusion alone by gated SPECT myocardial perfusion imaging for detection of severe three-vessel coronary artery disease. J Am Coll Cardiol 2003;42:64-70.PubMedCrossRef Lima RS, Watson DD, Goode AR, et al. Incremental value of combined perfusion and function over perfusion alone by gated SPECT myocardial perfusion imaging for detection of severe three-vessel coronary artery disease. J Am Coll Cardiol 2003;42:64-70.PubMedCrossRef
4.
go back to reference Taillefer R, DePuey EG, Udelson JE, Beller GA, Latour Y, Reeves F. Comparative diagnostic accuracy of Tl-201 and Tc-99m sestamibi SPECT imaging (perfusion and ECG-gated SPECT) in detecting coronary artery disease in women. J Am Coll Cardiol 1997;29:69-77.PubMedCrossRef Taillefer R, DePuey EG, Udelson JE, Beller GA, Latour Y, Reeves F. Comparative diagnostic accuracy of Tl-201 and Tc-99m sestamibi SPECT imaging (perfusion and ECG-gated SPECT) in detecting coronary artery disease in women. J Am Coll Cardiol 1997;29:69-77.PubMedCrossRef
5.
go back to reference Rehn T, Griffith LS, Achuff SC, et al. Exercise thallium-201 myocardial imaging in left main coronary artery disease: sensitive but not specific. Am J Cardiol 1981;48:217-23.PubMedCrossRef Rehn T, Griffith LS, Achuff SC, et al. Exercise thallium-201 myocardial imaging in left main coronary artery disease: sensitive but not specific. Am J Cardiol 1981;48:217-23.PubMedCrossRef
6.
go back to reference Christian TF, Miller TD, Bailey KR, Gibbons RJ. Noninvasive identification of severe coronary artery disease using exercise tomographic thallium-201 imaging. Am J Cardiol 1992;70:14-20.PubMedCrossRef Christian TF, Miller TD, Bailey KR, Gibbons RJ. Noninvasive identification of severe coronary artery disease using exercise tomographic thallium-201 imaging. Am J Cardiol 1992;70:14-20.PubMedCrossRef
7.
go back to reference Iskandrian AS. Myocardial ischemia during pharmacological stress testing. Circulation. 1993;87:1415-7.PubMed Iskandrian AS. Myocardial ischemia during pharmacological stress testing. Circulation. 1993;87:1415-7.PubMed
8.
go back to reference Hachamovitch R, Berman DS, Kiat H, et al. Exercise myocardial perfusion SPECT in patients without known coronary artery disease: incremental prognostic value and use in risk stratification. Circulation 1996;93:905-14.PubMed Hachamovitch R, Berman DS, Kiat H, et al. Exercise myocardial perfusion SPECT in patients without known coronary artery disease: incremental prognostic value and use in risk stratification. Circulation 1996;93:905-14.PubMed
9.
go back to reference Boucher CA, Zir LM, Beller GA, et al. Increased lung uptake of thallium-201 during exercise myocardial imaging: Clinical, hemodynamic and angiographic implications in patients with coronary artery disease. Am J Cardiol 1980;46:189-96.PubMedCrossRef Boucher CA, Zir LM, Beller GA, et al. Increased lung uptake of thallium-201 during exercise myocardial imaging: Clinical, hemodynamic and angiographic implications in patients with coronary artery disease. Am J Cardiol 1980;46:189-96.PubMedCrossRef
10.
go back to reference Mazzanti M, Germano G, Kiat H, et al. Identification of severe and extensive coronary artery disease by automatic measurement of transient ischemic dilation of the left ventricle in dual-isotope myocardial perfusion SPECT. J Am Coll Cardiol 1996;27:1612-20.PubMedCrossRef Mazzanti M, Germano G, Kiat H, et al. Identification of severe and extensive coronary artery disease by automatic measurement of transient ischemic dilation of the left ventricle in dual-isotope myocardial perfusion SPECT. J Am Coll Cardiol 1996;27:1612-20.PubMedCrossRef
11.
go back to reference Shirai N, Yamagishi H, Yoshiyama M, et al. Incremental value of assessment of regional wall motion for detection of multivessel coronary artery disease in exercise (201)Tl gated myocardial perfusion imaging. J Nucl Med 2002;43:443-50.PubMed Shirai N, Yamagishi H, Yoshiyama M, et al. Incremental value of assessment of regional wall motion for detection of multivessel coronary artery disease in exercise (201)Tl gated myocardial perfusion imaging. J Nucl Med 2002;43:443-50.PubMed
12.
go back to reference Williams KA, Schneider CM. Increased stress right ventricular activity on dual isotope perfusion SPECT: A sign of multivessel and/or left main coronary artery disease. J Am Coll Cardiol 1999;34:420-7.PubMedCrossRef Williams KA, Schneider CM. Increased stress right ventricular activity on dual isotope perfusion SPECT: A sign of multivessel and/or left main coronary artery disease. J Am Coll Cardiol 1999;34:420-7.PubMedCrossRef
13.
go back to reference Williams KA, Schuster RA, Williams KA Jr, Schneider CM, Pokharna HK. Correct spatial normalization of myocardial perfusion SPECT improves detection of multivessel coronary artery disease. J Nucl Cardiol 2003;10:353-60.PubMedCrossRef Williams KA, Schuster RA, Williams KA Jr, Schneider CM, Pokharna HK. Correct spatial normalization of myocardial perfusion SPECT improves detection of multivessel coronary artery disease. J Nucl Cardiol 2003;10:353-60.PubMedCrossRef
14.
go back to reference Bateman TM, Heller GV, McGhie AI, et al. Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: Comparison with ECG-gated Tc-99 m sestamibi SPECT. J Nucl Cardiol 2006;13:24-33.PubMedCrossRef Bateman TM, Heller GV, McGhie AI, et al. Diagnostic accuracy of rest/stress ECG-gated Rb-82 myocardial perfusion PET: Comparison with ECG-gated Tc-99 m sestamibi SPECT. J Nucl Cardiol 2006;13:24-33.PubMedCrossRef
15.
go back to reference Hida S, Chikamori T, Tanaka H, et al. Diagnostic value of left ventricular function after stress and at rest in the detection of multivessel coronary artery disease as assessed by electrocardiogram-gated SPECT. J Nucl Cardiol 2007;14:68-74.PubMedCrossRef Hida S, Chikamori T, Tanaka H, et al. Diagnostic value of left ventricular function after stress and at rest in the detection of multivessel coronary artery disease as assessed by electrocardiogram-gated SPECT. J Nucl Cardiol 2007;14:68-74.PubMedCrossRef
16.
go back to reference Hida S. Diagnostic value of left ventricular function after adenosine triphosphate loading and at rest in the detection of multi-vessel coronary artery disease using myocardial perfusion imaging. J Nucl Cardiol 2008;15. Hida S. Diagnostic value of left ventricular function after adenosine triphosphate loading and at rest in the detection of multi-vessel coronary artery disease using myocardial perfusion imaging. J Nucl Cardiol 2008;15.
Metadata
Title
Detection of multivessel coronary artery disease: looking beyond the extent of perfusion abnormalities
Authors
Dipan Desai, DO
Gorgi Kozeski, DO
Olakunle Akinboboye, MD
Publication date
01-02-2009
Publisher
Springer-Verlag
Published in
Journal of Nuclear Cardiology / Issue 1/2009
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-008-9036-y

Other articles of this Issue 1/2009

Journal of Nuclear Cardiology 1/2009 Go to the issue

ASNC Announcement

ASNC Announcement

ASNC Announcement

ASNC Announcement