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Open Access 01-12-2024 | Desogestrel | Correspondence

Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response

Authors: Caroline Sevoz-Couche, Maxime Patout, Beny Charbit, Thomas Similowski, Christian Straus

Published in: Respiratory Research | Issue 1/2024

Abstract

After a fortuitous observation of two cases of chemosensitivity recovery in women with congenital central hypoventilation syndrome (CCHS) who took desogestrel, we aimed to evaluate the ventilatory response to hypercapnia of five CCHS patients with or without treatment consisting of desogestrel (DESO) or levonorgestrel (LEVO). Only two patients became responsive to hypercapnia under treatment, according to their basal vagal heart rate variability. These results suggest that heart rate variability may be promising tool to discriminate patients susceptible to become responsive to hypercapnia under DESO-LEVO treatment.

Clinical Trials Identifier NCT01243697

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Title: Higher baseline heart rate variability in CCHS patients with progestin-associated recovery of hypercapnic ventilatory response
Authors: Caroline Sevoz-Couche
Maxime Patout
Beny Charbit
Thomas Similowski
Christian Straus
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Desogestrel
Levonorgestrel
Progestin
Oral Contraception
Ethinylestradiol
Published in: Respiratory Research / Issue 1/2024
Electronic ISSN: 1465-993X
DOI: https://doi.org/10.1186/s12931-023-02625-w

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