Skip to main content
Top
Published in: European Journal of Pediatrics 6/2012

Open Access 01-06-2012 | Original Article

Practical consensus guidelines for the management of enuresis

Authors: Johan Vande Walle, Soren Rittig, Stuart Bauer, Paul Eggert, Daniela Marschall-Kehrel, Serdar Tekgul

Published in: European Journal of Pediatrics | Issue 6/2012

Login to get access

Abstract

Despite the high prevalence of enuresis, the professional training of doctors in the evaluation and management of this condition is often minimal and/or inconsistent. Therefore, patient care is neither optimal nor efficient, which can have a profound impact on affected children and their families. Once comprehensive history taking and evaluation has eliminated daytime symptoms or comorbidities, monosymptomatic enuresis can be managed efficaciously in the majority of patients. Non-monosymptomatic enuresis is often a more complex condition; these patients may benefit from referral to specialty care centers. We outline two alternative strategies to determine the most appropriate course of care. The first is a basic assessment covering only the essential components of diagnostic investigation which can be carried out in one office visit. The second strategy includes several additional evaluations including completion of a voiding diary, which requires extra time during the initial consultation and two office visits before treatment or specialty referral is provided. This should yield greater success than first-line treatment. Conclusion: This guideline, endorsed by major international pediatric urology and nephrology societies, aims to equip a general pediatric practice in both primary and secondary care with simple yet comprehensive guidelines and practical tools (i.e., checklists, diary templates, and quick-reference flowcharts) for complete evaluation and successful treatment of enuresis.
Literature
1.
go back to reference Baeyens D, Lierman A, Roeyers H, Hoebeke P, Walle JV (2009) Adherence in children with nocturnal enuresis. J Pediatr Urol 5(2):105–109PubMedCrossRef Baeyens D, Lierman A, Roeyers H, Hoebeke P, Walle JV (2009) Adherence in children with nocturnal enuresis. J Pediatr Urol 5(2):105–109PubMedCrossRef
2.
go back to reference Berry AK (2006) Helping children with nocturnal enuresis: the wait-and-see approach may not be in anyone's best interests. Am J Nurs 106(8):56–63PubMedCrossRef Berry AK (2006) Helping children with nocturnal enuresis: the wait-and-see approach may not be in anyone's best interests. Am J Nurs 106(8):56–63PubMedCrossRef
3.
go back to reference Butler R, McKenna S (2002) Overcoming parental intolerance in childhood nocturnal enuresis: a survey of professional opinion. BJU Int 89(3):295–297PubMedCrossRef Butler R, McKenna S (2002) Overcoming parental intolerance in childhood nocturnal enuresis: a survey of professional opinion. BJU Int 89(3):295–297PubMedCrossRef
4.
go back to reference Butler RJ, Holland P, Robinson J (2001) Examination of the structured withdrawal program to prevent relapse of nocturnal enuresis. J Urol 166(6):2463–2466PubMedCrossRef Butler RJ, Holland P, Robinson J (2001) Examination of the structured withdrawal program to prevent relapse of nocturnal enuresis. J Urol 166(6):2463–2466PubMedCrossRef
5.
go back to reference Carskadon MA (2004) Sleep deprivation: health consequences and societal impact. Med Clin North Am 88(3):767–776PubMedCrossRef Carskadon MA (2004) Sleep deprivation: health consequences and societal impact. Med Clin North Am 88(3):767–776PubMedCrossRef
6.
go back to reference Committee for Medicinal Products For Human Use (2006) Reflection paper: formulations of choice for the paediatric population. London. Available at: www.emea.europa.eu. Accessed 19 Jan 2012 Committee for Medicinal Products For Human Use (2006) Reflection paper: formulations of choice for the paediatric population. London. Available at: www.​emea.​europa.​eu. Accessed 19 Jan 2012
7.
go back to reference Culpepper L (2006) Secondary insomnia in the primary care setting: review of diagnosis, treatment, and management. Curr Med Res Opin 22(7):1257–1268PubMedCrossRef Culpepper L (2006) Secondary insomnia in the primary care setting: review of diagnosis, treatment, and management. Curr Med Res Opin 22(7):1257–1268PubMedCrossRef
8.
go back to reference De Guchtenaere A, Raes A, Vande Walle C et al (2009) Evidence of partial anti-enuretic response related to poor pharmacodynamic effects of desmopressin nasal spray. J Urol 181(1):302–309PubMedCrossRef De Guchtenaere A, Raes A, Vande Walle C et al (2009) Evidence of partial anti-enuretic response related to poor pharmacodynamic effects of desmopressin nasal spray. J Urol 181(1):302–309PubMedCrossRef
9.
go back to reference De Jonge DA (1973) Epidemiology of enuresis: a survey of the literature. In: Kolvin I, MacKeith RC, Meadow SR (eds) Bladder control and enuresis. Heinemann Medical Books, London De Jonge DA (1973) Epidemiology of enuresis: a survey of the literature. In: Kolvin I, MacKeith RC, Meadow SR (eds) Bladder control and enuresis. Heinemann Medical Books, London
10.
go back to reference Dehoorne JL, Raes AM, Van LE, Hoebeke P, Vande Walle JG (2006) Desmopressin resistant nocturnal polyuria secondary to increased nocturnal osmotic excretion. J Urol 176(2):749–753PubMedCrossRef Dehoorne JL, Raes AM, Van LE, Hoebeke P, Vande Walle JG (2006) Desmopressin resistant nocturnal polyuria secondary to increased nocturnal osmotic excretion. J Urol 176(2):749–753PubMedCrossRef
11.
go back to reference Dogan HS, Akpinar B, Gurocak S, Akata D, Bakkaloglu M, Tekgul S (2008) Non-invasive evaluation of voiding function in asymptomatic primary school children. Pediatr Nephrol 23(7):1115–1122PubMedCrossRef Dogan HS, Akpinar B, Gurocak S, Akata D, Bakkaloglu M, Tekgul S (2008) Non-invasive evaluation of voiding function in asymptomatic primary school children. Pediatr Nephrol 23(7):1115–1122PubMedCrossRef
12.
go back to reference Ertan P, Yilmaz O, Caglayan M, Sogut A, Aslan S, Yuksel H (2009) Relationship of sleep quality and quality of life in children with monosymptomatic enuresis. Child Care Health Dev 35(4):469–474PubMedCrossRef Ertan P, Yilmaz O, Caglayan M, Sogut A, Aslan S, Yuksel H (2009) Relationship of sleep quality and quality of life in children with monosymptomatic enuresis. Child Care Health Dev 35(4):469–474PubMedCrossRef
13.
14.
go back to reference Evans J, Malmsten B, Maddocks A, Popli HS, Lottmann H (2011) Randomized comparison of long-term desmopressin and alarm treatment for bedwetting. J Pediatr Urol 7(1):21–29PubMedCrossRef Evans J, Malmsten B, Maddocks A, Popli HS, Lottmann H (2011) Randomized comparison of long-term desmopressin and alarm treatment for bedwetting. J Pediatr Urol 7(1):21–29PubMedCrossRef
15.
go back to reference Farhat W, McLorie GA, O’Reilly S, Khoury A, Bägli DJ (2001) Reliability of the pediatric dysfunctional voiding symptom score in monitoring response to behavioral modification. Can J Urol 8(6):1401–1405PubMed Farhat W, McLorie GA, O’Reilly S, Khoury A, Bägli DJ (2001) Reliability of the pediatric dysfunctional voiding symptom score in monitoring response to behavioral modification. Can J Urol 8(6):1401–1405PubMed
16.
go back to reference Fergusson DM, Horwood LJ, Shannon FT (1986) Factors related to the age of attainment of nocturnal bladder control: an 8-year longitudinal study. Pediatrics 78(5):884–990PubMed Fergusson DM, Horwood LJ, Shannon FT (1986) Factors related to the age of attainment of nocturnal bladder control: an 8-year longitudinal study. Pediatrics 78(5):884–990PubMed
17.
go back to reference Foxman B, Valdez RB, Brook RH (1986) Childhood enuresis: prevalence, perceived impact, and prescribed treatments. Pediatrics 77(4):482–487PubMed Foxman B, Valdez RB, Brook RH (1986) Childhood enuresis: prevalence, perceived impact, and prescribed treatments. Pediatrics 77(4):482–487PubMed
18.
go back to reference Garber KM (1996) Enuresis: an update on diagnosis and management. J Pediatr Health Care 10(5):202–208PubMedCrossRef Garber KM (1996) Enuresis: an update on diagnosis and management. J Pediatr Health Care 10(5):202–208PubMedCrossRef
19.
go back to reference Glazener CM, Evans JH, Peto RE (2005) Alarm interventions for nocturnal enuresis in children. Cochrane Database Syst Rev (2):CD002911 Glazener CM, Evans JH, Peto RE (2005) Alarm interventions for nocturnal enuresis in children. Cochrane Database Syst Rev (2):CD002911
20.
go back to reference Hagglof B, Andren O, Bergstrom E, Marklund L, Wendelius M (1997) Self-esteem before and after treatment in children with nocturnal enuresis and urinary incontinence. Scand J Urol Nephrol Suppl 183:79–82PubMed Hagglof B, Andren O, Bergstrom E, Marklund L, Wendelius M (1997) Self-esteem before and after treatment in children with nocturnal enuresis and urinary incontinence. Scand J Urol Nephrol Suppl 183:79–82PubMed
21.
go back to reference Hansen MN, Rittig S, Siggaard C et al (2001) Intra-individual variability in nighttime urine production and functional bladder capacity estimated by home recordings in patients with nocturnal enuresis. J Urol 166(6):2452–2455PubMedCrossRef Hansen MN, Rittig S, Siggaard C et al (2001) Intra-individual variability in nighttime urine production and functional bladder capacity estimated by home recordings in patients with nocturnal enuresis. J Urol 166(6):2452–2455PubMedCrossRef
22.
go back to reference Hellström AL, Hanson E, Hansson S, Hjälmås K, Jodal U (1990) Micturition habits and incontinence in 7-year-old Swedish school entrants. Eur J Pediatr 149(6):434–437PubMedCrossRef Hellström AL, Hanson E, Hansson S, Hjälmås K, Jodal U (1990) Micturition habits and incontinence in 7-year-old Swedish school entrants. Eur J Pediatr 149(6):434–437PubMedCrossRef
23.
go back to reference Hislop J, Arber S (2003) Sleepers wake! The gendered nature of sleep disruption among mid-life women. Sociology 37:695–711CrossRef Hislop J, Arber S (2003) Sleepers wake! The gendered nature of sleep disruption among mid-life women. Sociology 37:695–711CrossRef
24.
go back to reference Hjalmas K, Arnold T, Bower W et al (2004) Nocturnal enuresis: an international evidence based management strategy. J Urol 171(6 Pt 2):2545–2561PubMedCrossRef Hjalmas K, Arnold T, Bower W et al (2004) Nocturnal enuresis: an international evidence based management strategy. J Urol 171(6 Pt 2):2545–2561PubMedCrossRef
25.
go back to reference Hunsballe JM, Rittig S, Djurhuus JC (1995) Sleep and arousal in adolescents and adults with nocturnal enuresis. Scand J Urol Nephrol Suppl 173:59–60PubMed Hunsballe JM, Rittig S, Djurhuus JC (1995) Sleep and arousal in adolescents and adults with nocturnal enuresis. Scand J Urol Nephrol Suppl 173:59–60PubMed
26.
go back to reference Kamperis K, Hagstroem S, Rittig S, Djurhuus JC (2008) Combination of the enuresis alarm and desmopressin: second line treatment for nocturnal enuresis. J Urol 179(3):1128–1131PubMedCrossRef Kamperis K, Hagstroem S, Rittig S, Djurhuus JC (2008) Combination of the enuresis alarm and desmopressin: second line treatment for nocturnal enuresis. J Urol 179(3):1128–1131PubMedCrossRef
27.
go back to reference Longstaffe S, Moffatt ME, Whalen JC (2000) Behavioral and self-concept changes after six months of enuresis treatment: a randomized, controlled trial. Pediatrics 105(4 Pt 2):935–940PubMed Longstaffe S, Moffatt ME, Whalen JC (2000) Behavioral and self-concept changes after six months of enuresis treatment: a randomized, controlled trial. Pediatrics 105(4 Pt 2):935–940PubMed
28.
go back to reference Lottmann H, Froeling F, Alloussi S et al (2007) A randomised comparison of oral desmopressin lyophilisate (MELT) and tablet formulations in children and adolescents with primary nocturnal enuresis. Int J Clin Pract 61(9):1454–1460PubMedCrossRef Lottmann H, Froeling F, Alloussi S et al (2007) A randomised comparison of oral desmopressin lyophilisate (MELT) and tablet formulations in children and adolescents with primary nocturnal enuresis. Int J Clin Pract 61(9):1454–1460PubMedCrossRef
29.
go back to reference Marschall-Kehrel D, Harms TW (2009) Structured desmopressin withdrawal improves response and treatment outcome for monosymptomatic enuretic children. J Urol 182(4 Suppl):2022–2026PubMedCrossRef Marschall-Kehrel D, Harms TW (2009) Structured desmopressin withdrawal improves response and treatment outcome for monosymptomatic enuretic children. J Urol 182(4 Suppl):2022–2026PubMedCrossRef
30.
go back to reference National Institute for Health and Clinical Excellence (2010) Nocturnal enuresis: the management of bedwetting in children and young people. NICE, London National Institute for Health and Clinical Excellence (2010) Nocturnal enuresis: the management of bedwetting in children and young people. NICE, London
31.
go back to reference Neveus T, Eggert P, Evans J et al (2010) Evaluation of and treatment for monosymptomatic enuresis: a standardization document from the International Children’s Continence Society. J Urol 183(2):441–447PubMedCrossRef Neveus T, Eggert P, Evans J et al (2010) Evaluation of and treatment for monosymptomatic enuresis: a standardization document from the International Children’s Continence Society. J Urol 183(2):441–447PubMedCrossRef
32.
go back to reference Neveus T, Hetta J, Cnattingius S et al (1999) Depth of sleep and sleep habits among enuretic and incontinent children. Acta Paediatr 88(7):748–752PubMedCrossRef Neveus T, Hetta J, Cnattingius S et al (1999) Depth of sleep and sleep habits among enuretic and incontinent children. Acta Paediatr 88(7):748–752PubMedCrossRef
33.
go back to reference Nevéus T, von Gontard A, Hoebeke P et al (2006) The standardisation of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children’s Continence Society (ICCS). J Urol 176(1):314–324PubMedCrossRef Nevéus T, von Gontard A, Hoebeke P et al (2006) The standardisation of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children’s Continence Society (ICCS). J Urol 176(1):314–324PubMedCrossRef
34.
go back to reference Pugner K, Holmes J (1997) Nocturnal enuresis: economic impacts and self-esteem preliminary research results. Scand J Urol Nephrol Suppl 183:65–69PubMed Pugner K, Holmes J (1997) Nocturnal enuresis: economic impacts and self-esteem preliminary research results. Scand J Urol Nephrol Suppl 183:65–69PubMed
35.
go back to reference Raes A, Dehoorne J, Van LE, Hoebeke P, Vande WC, Vansintjan P et al (2007) Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights. J Urol 178(3 Pt 1):1048–1051PubMedCrossRef Raes A, Dehoorne J, Van LE, Hoebeke P, Vande WC, Vansintjan P et al (2007) Partial response to intranasal desmopressin in children with monosymptomatic nocturnal enuresis is related to persistent nocturnal polyuria on wet nights. J Urol 178(3 Pt 1):1048–1051PubMedCrossRef
36.
go back to reference Rembratt A, Graugaard-Jensen C, Senderovitz T, Nørgaard JP, Djurhuus JC (2004) Pharmacokinetics and pharmacodynamics of desmopressin administered orally versus intravenously at daytime versus night-time in healthy men aged 55–70 years. Eur J Clin Pharmacol 60(6):397–402PubMedCrossRef Rembratt A, Graugaard-Jensen C, Senderovitz T, Nørgaard JP, Djurhuus JC (2004) Pharmacokinetics and pharmacodynamics of desmopressin administered orally versus intravenously at daytime versus night-time in healthy men aged 55–70 years. Eur J Clin Pharmacol 60(6):397–402PubMedCrossRef
37.
go back to reference Riley KE (1997) Evaluation and management of primary nocturnal enuresis. J Am Acad Nurse Pract 9(1):33–39PubMedCrossRef Riley KE (1997) Evaluation and management of primary nocturnal enuresis. J Am Acad Nurse Pract 9(1):33–39PubMedCrossRef
38.
go back to reference Rittig S, Jensen AR, Jensen KT, Pedersen EB (1998) Effect of food intake on the pharmacokinetics and antidiuretic activity of oral desmopressin (DDAVP) in hydrated normal subjects. Clin Endocrinol (Oxf) 48(2):235–241CrossRef Rittig S, Jensen AR, Jensen KT, Pedersen EB (1998) Effect of food intake on the pharmacokinetics and antidiuretic activity of oral desmopressin (DDAVP) in hydrated normal subjects. Clin Endocrinol (Oxf) 48(2):235–241CrossRef
39.
go back to reference Rittig S, Schaumburg HL, Siggaard C, Schmidt F, Djurhuus JC (2008) The circadian defect in plasma vasopressin and urine output is related to desmopressin response and enuresis status in children with nocturnal enuresis. J Urol 179(6):2389–2395PubMedCrossRef Rittig S, Schaumburg HL, Siggaard C, Schmidt F, Djurhuus JC (2008) The circadian defect in plasma vasopressin and urine output is related to desmopressin response and enuresis status in children with nocturnal enuresis. J Urol 179(6):2389–2395PubMedCrossRef
40.
go back to reference Robson L (2007) Bedwetting. Parkhurst Exch 15(12):66–67 Robson L (2007) Bedwetting. Parkhurst Exch 15(12):66–67
41.
go back to reference Robson WL (2009) Clinical practice. Evaluation and management of enuresis. N Engl J Med 360(14):1429–1436PubMedCrossRef Robson WL (2009) Clinical practice. Evaluation and management of enuresis. N Engl J Med 360(14):1429–1436PubMedCrossRef
42.
go back to reference Rush EC, Chhichhia P, Kilding AE, Plank LD (2010) Water turnover in children and young adults. Eur J Appl Physiol 110:1209–1214PubMedCrossRef Rush EC, Chhichhia P, Kilding AE, Plank LD (2010) Water turnover in children and young adults. Eur J Appl Physiol 110:1209–1214PubMedCrossRef
43.
go back to reference Sapi MC, Vasconcelos JS, Silva FG, Damião R, da Silva EA (2009) Assessment of domestic violence against children and adolescents with enuresis. J Pediatr (Rio J) 85(5):433–437 Sapi MC, Vasconcelos JS, Silva FG, Damião R, da Silva EA (2009) Assessment of domestic violence against children and adolescents with enuresis. J Pediatr (Rio J) 85(5):433–437
45.
go back to reference Sit FKY, Yeung CK, Sihoe JDY, Liu JWH (2003) Self-esteem before and after treatment in Chinese children with nocturnal enuresis and urinary incontinence: a qualitative approach. ICCS Abstracts 40 Sit FKY, Yeung CK, Sihoe JDY, Liu JWH (2003) Self-esteem before and after treatment in Chinese children with nocturnal enuresis and urinary incontinence: a qualitative approach. ICCS Abstracts 40
46.
go back to reference Tekgul S, Nijman R, Hoebeke P, Canning D, Bower W, von Gontard A (2009) Diagnosis and management of urinary incontinence in childhood. Report from the 4th International Consultation on Incontinence. Health Publication Ltd Tekgul S, Nijman R, Hoebeke P, Canning D, Bower W, von Gontard A (2009) Diagnosis and management of urinary incontinence in childhood. Report from the 4th International Consultation on Incontinence. Health Publication Ltd
48.
go back to reference Theunis M, Van Hoecke E, Paesbrugge S, Hoebeke P, Vande Walle J (2002) Self-image and performance in children with nocturnal enuresis. Eur Urol 41(6):660–667PubMedCrossRef Theunis M, Van Hoecke E, Paesbrugge S, Hoebeke P, Vande Walle J (2002) Self-image and performance in children with nocturnal enuresis. Eur Urol 41(6):660–667PubMedCrossRef
49.
go back to reference van Dommelen P, Kamphuis M, Van Leerdam FJ et al (2009) The short- and long-term effects of simple behavioral interventions for nocturnal enuresis in young children: a randomized controlled trial. J Pediatr 154:662–666PubMedCrossRef van Dommelen P, Kamphuis M, Van Leerdam FJ et al (2009) The short- and long-term effects of simple behavioral interventions for nocturnal enuresis in young children: a randomized controlled trial. J Pediatr 154:662–666PubMedCrossRef
50.
go back to reference Van Herzeele C, Alova I, Evans J et al (2009) Poor compliance with primary nocturnal enuresis therapy may contribute to insufficient desmopressin response. J Urol 182(4 Suppl):2045–2049PubMedCrossRef Van Herzeele C, Alova I, Evans J et al (2009) Poor compliance with primary nocturnal enuresis therapy may contribute to insufficient desmopressin response. J Urol 182(4 Suppl):2045–2049PubMedCrossRef
51.
go back to reference van Kerrebroeck PE, Nørgaard JP (2009) Desmopressin for the treatment of primary nocturnal enuresis. Ped Health 3:311–327CrossRef van Kerrebroeck PE, Nørgaard JP (2009) Desmopressin for the treatment of primary nocturnal enuresis. Ped Health 3:311–327CrossRef
52.
go back to reference van Londen A, van Londen-Barentsen MW, van Son MJ, Mulder GA (1993) Arousal training for children suffering from nocturnal enuresis: a 2 1/2 year follow-up. Behav Res Ther 31(6):613–615PubMedCrossRef van Londen A, van Londen-Barentsen MW, van Son MJ, Mulder GA (1993) Arousal training for children suffering from nocturnal enuresis: a 2 1/2 year follow-up. Behav Res Ther 31(6):613–615PubMedCrossRef
53.
go back to reference Vande Walle J, Vande Walle C, Van SP et al (2007) Nocturnal polyuria is related to 24-hour diuresis and osmotic excretion in an enuresis population referred to a tertiary center. J Urol 178(6):2630–2634PubMedCrossRef Vande Walle J, Vande Walle C, Van SP et al (2007) Nocturnal polyuria is related to 24-hour diuresis and osmotic excretion in an enuresis population referred to a tertiary center. J Urol 178(6):2630–2634PubMedCrossRef
54.
go back to reference Vande Walle JG, Bogaert GA, Mattsson S et al (2006) A new fast-melting oral formulation of desmopressin: a pharmacodynamic study in children with primary nocturnal enuresis. BJU Int 97(3):603–609PubMedCrossRef Vande Walle JG, Bogaert GA, Mattsson S et al (2006) A new fast-melting oral formulation of desmopressin: a pharmacodynamic study in children with primary nocturnal enuresis. BJU Int 97(3):603–609PubMedCrossRef
55.
go back to reference von Gontard A (2009) Psychological aspects of urinary incontinence, enuresis and faecal incontinence. In: Abrams P, Cardozo L, Khoury S, Wein A (eds). Report from the 4th International Consultation on Incontinence. 4th edition. Health Publication Ltd, p. 760–792 von Gontard A (2009) Psychological aspects of urinary incontinence, enuresis and faecal incontinence. In: Abrams P, Cardozo L, Khoury S, Wein A (eds). Report from the 4th International Consultation on Incontinence. 4th edition. Health Publication Ltd, p. 760–792
56.
go back to reference Wagner WG, Johnson JT (1988) Childhood nocturnal enuresis: the prediction of premature withdrawal from behavioral conditioning. J Abnorm Child Psychol 16(6):687–692PubMedCrossRef Wagner WG, Johnson JT (1988) Childhood nocturnal enuresis: the prediction of premature withdrawal from behavioral conditioning. J Abnorm Child Psychol 16(6):687–692PubMedCrossRef
57.
go back to reference Watanabe H, Kawauchi A, Kitamori T, Azuma Y (1994) Treatment system for nocturnal enuresis according to an original classification system. Eur Urol 25(1):43–50PubMed Watanabe H, Kawauchi A, Kitamori T, Azuma Y (1994) Treatment system for nocturnal enuresis according to an original classification system. Eur Urol 25(1):43–50PubMed
59.
go back to reference Woo SH, Park KH (2004) Enuresis alarm treatment as a second line to pharmacotherapy in children with monosymptomatic nocturnal enuresis. J Urol 171(6 Pt 2):2615–2617PubMedCrossRef Woo SH, Park KH (2004) Enuresis alarm treatment as a second line to pharmacotherapy in children with monosymptomatic nocturnal enuresis. J Urol 171(6 Pt 2):2615–2617PubMedCrossRef
60.
go back to reference Yeung CK, Diao M, Sreedhar B (2008) Cortical arousal in children with severe enuresis. N Engl J Med 358(22):2414–2415PubMedCrossRef Yeung CK, Diao M, Sreedhar B (2008) Cortical arousal in children with severe enuresis. N Engl J Med 358(22):2414–2415PubMedCrossRef
61.
go back to reference Yeung CK, Sihoe JD, Sit FK, Bower W, Sreedhar B, Lau J (2004) Characteristics of primary nocturnal enuresis in adults: an epidemiological study. BJU Int 93(3):341–345PubMedCrossRef Yeung CK, Sihoe JD, Sit FK, Bower W, Sreedhar B, Lau J (2004) Characteristics of primary nocturnal enuresis in adults: an epidemiological study. BJU Int 93(3):341–345PubMedCrossRef
62.
go back to reference Yeung CK, Sit FK, To LK et al (2002) Reduction in nocturnal functional bladder capacity is a common factor in the pathogenesis of refractory nocturnal enuresis. BJU Int 90(3):302–307PubMedCrossRef Yeung CK, Sit FK, To LK et al (2002) Reduction in nocturnal functional bladder capacity is a common factor in the pathogenesis of refractory nocturnal enuresis. BJU Int 90(3):302–307PubMedCrossRef
63.
go back to reference Yeung CK, Sreedhar B, Sihoe JD, Sit FK, Lau J (2006) Differences in characteristics of nocturnal enuresis between children and adolescents: a critical appraisal from a large epidemiological study. BJU Int 97(5):1069–1073PubMedCrossRef Yeung CK, Sreedhar B, Sihoe JD, Sit FK, Lau J (2006) Differences in characteristics of nocturnal enuresis between children and adolescents: a critical appraisal from a large epidemiological study. BJU Int 97(5):1069–1073PubMedCrossRef
Metadata
Title
Practical consensus guidelines for the management of enuresis
Authors
Johan Vande Walle
Soren Rittig
Stuart Bauer
Paul Eggert
Daniela Marschall-Kehrel
Serdar Tekgul
Publication date
01-06-2012
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 6/2012
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-012-1687-7

Other articles of this Issue 6/2012

European Journal of Pediatrics 6/2012 Go to the issue